Articles
Page 1 of 18
-
Citation: AIDS Research and Therapy 2024 21:26
-
Severe BCG immune reconstitution inflammatory syndrome lymphadenitis successfully managed with pre-antiretroviral counseling and a non-surgical approach: a case report
Bacillus Calmette-Guérin (BCG) reactions are the most common cause of immune reconstitution inflammatory syndrome (IRIS) in HIV-positive infants who initiate antiretroviral therapy (ART). There is limited evid...
Citation: AIDS Research and Therapy 2024 21:25 -
Exploring the association between erythema multiforme and HIV infection: some mechanisms and implications
Erythema multiforme (EM) is an immune-mediated mucocutaneous condition characterized by hypersensitivity reactions to antigenic stimuli from infectious agents and certain drugs. The most commonly implicated in...
Citation: AIDS Research and Therapy 2024 21:24 -
Prevalence of overweight and obesity among adolescents living with HIV after dolutegravir - based antiretroviral therapy start in Kampala, Uganda
Dolutegravir (DTG)-based antiretroviral therapy (ART) is currently the preferred first-line treatment for persons living with HIV (PLHIV) including children and adolescents in many low- and middle-income count...
Citation: AIDS Research and Therapy 2024 21:23 -
Evaluation of the effects of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on ART at Mbarara Regional Referral Hospital: a double-blind randomized controlled clinical trial
Initiation of ART among people living with HIV (PLWH) having a CD4 count ≤ 350cells/µl, produces poor immunological recovery, putting them at a high risk of opportunistic infections. To mitigate this, PLWH on ...
Citation: AIDS Research and Therapy 2024 21:22 -
Evaluation of an HIV homecare program for lost-to-follow-up populations: a mixed methods study in Detroit, Michigan
Maintaining people living with HIV (PLWHIV) in clinical care is a global priority. In the Metro Detroit area of Michigan, approximately 30% of PLWHIV are out of care. To re-engage lost-to-follow-up patients, W...
Citation: AIDS Research and Therapy 2024 21:21 -
Missed opportunities for HIV testing and sexual health-related challenges in an individual with intellectual disability: a case report
HIV testing remains an important tool in identifying people living with HIV/AIDS (PLWHA). An early diagnosis of HIV can lead to a prolonged life expectancy if treatment is initiated promptly. Indicator conditi...
Citation: AIDS Research and Therapy 2024 21:20 -
Secondary syphilis presenting with alopecia and leukoderma in a stable HIV-positive patient in a resource-limited setting: a case report
Syphilis is an infection caused by the bacteria Treponema pallidum. It is mainly transmitted through oral, vaginal and anal sex, in pregnancy and through blood transfusion. Syphilis develops in primary, secondary...
Citation: AIDS Research and Therapy 2024 21:19 -
Presence of tuberculosis symptoms among HIV-positive men who have sex with men (MSM) in Zimbabwe
We conducted secondary data analysis using a biobehavioral survey dataset of 1538 MSM from Zimbabwe. Survey participants were screened for the four symptoms suggestive of tuberculosis infection using the WHO T...
Citation: AIDS Research and Therapy 2024 21:18 -
Efficacy and safety of switching to dolutegravir/lamivudine in virologically suppressed people with HIV-1 aged ≥ 50 years: week 48 pooled results from the TANGO and SALSA studies
As the population of people with HIV ages, concerns over managing age-related comorbidities, polypharmacy, immune recovery, and drug-drug interactions while maintaining viral suppression have arisen. We presen...
Citation: AIDS Research and Therapy 2024 21:17 -
Assessing high-risk sexual practices associated with human immunodeficiency virus infection among young female sex workers in Lubumbashi, Democratic Republic of the Congo: a cross-sectional study
Young female sex workers (YFSWs) face a higher risk of HIV infection compared to older workers, but there is a lack of comprehensive data on their sexual practices and HIV infection risks, which may present un...
Citation: AIDS Research and Therapy 2024 21:16 -
Factors influencing rapid antiretroviral therapy initiation in Jiulongpo, Chongqing, China: a retrospective cohort from 2018 to 2022
Antiretroviral Therapy (ART) is pivotal in extending the lives of people living with HIV (PLWH) and minimizing transmission. Rapid ART initiation, defined as commencing ART within seven days of HIV diagnosis, ...
Citation: AIDS Research and Therapy 2024 21:15 -
Support, not blame: safe partner disclosure among women diagnosed with HIV late in pregnancy in South Africa and Uganda
HIV partner disclosure rates remain low among pregnant women living with HIV in many African countries despite potential benefits for women and their families. Partner disclosure can trigger negative responses...
Citation: AIDS Research and Therapy 2024 21:14 -
Diffuse myocardial fibrosis is uncommon in people with perinatally acquired human immunodeficiency virus infection
Cardiovascular disease (CVD) remains a leading cause of death in people living with HIV. Myocardial fibrosis is well-described in HIV infection acquired in adulthood. We evaluate the burden of fibrosis by card...
Citation: AIDS Research and Therapy 2024 21:13 -
Brief communication: body composition and hidden obesity in people living with HIV on antiretroviral therapy
Increased incidence of lifestyle diseases as side-effects of antiretroviral therapy (ART) have been reported in people living with HIV (PLWH). Few studies have evaluated obesity and hidden obesity in Japanese ...
Citation: AIDS Research and Therapy 2024 21:12 -
Factors associated with knowledge of mother-to-child transmission of HIV among reproductive-age women in Indonesia: a multilevel analysis
Maternal transmission of human immunodeficiency virus (HIV) commonly occurs from mother to child during pregnancy, delivery, and breastfeeding which accounts for almost all the new HIV infections among childre...
Citation: AIDS Research and Therapy 2024 21:11 -
Characterization of intestinal fungal community diversity in people living with HIV/AIDS (PLWHA)
Acquired Immune Deficiency Syndrome (AIDS) is a highly dangerous infectious disease caused by the Human Immunodeficiency Virus (HIV), a virus that attacks the human immune system. To explore the correlation be...
Citation: AIDS Research and Therapy 2024 21:10 -
A call for change: addressing the implementation strategy using pre exposure Prophylaxis for combating the escalating HIV crisis in Zanzibar’s key populations
The Integrated Bio-Behavioural Surveillance Survey of 2022–2023 among key populations report from Zanzibar has been released. The prevalence of HIV is estimated to be 21.1%, 11.4%, and 9.3% among Female Sex Wo...
Citation: AIDS Research and Therapy 2024 21:9 -
Outcomes of antiretroviral treatment for 0-14-year-old children living with HIV in Ganzhou, China, 2006–2023
Studies on antiretroviral therapy (ART) in children living with HIV (CLHIV) are limited due to the small population and low accession rate of ART.
Citation: AIDS Research and Therapy 2024 21:8 -
Experiences of people living with HIV in low- and middle-income countries and their perspectives in self-management: a meta-synthesis
Availability of anti-retroviral treatment has changed HIV in to a manageable chronic disease, making effective self-management essential. However, only a few studies in low- and middle-income countries (LMICs)...
Citation: AIDS Research and Therapy 2024 21:7 -
Satisfaction of antiretroviral therapy services and its associated factors among adult clients attending antiretroviral therapy in Woliso town, Ethiopia
Antiretroviral therapy client satisfaction is a significant tool that enables to strengthen the quality of life of the clients. The study aimed to assess the satisfaction of clients with antiretroviral therapy...
Citation: AIDS Research and Therapy 2024 21:6 -
Hypertension among persons living with HIV/AIDS and its association with HIV-related health factors
Human Immunodeficiency Virus (HIV) infection remains a public health concern in many countries. The increased life expectancy in the post-Antiretroviral Therapy (ART) era has led to an increased risk of cardiovas...
Citation: AIDS Research and Therapy 2024 21:5 -
Effect of dolutegravir-based versus efavirenz-based antiretroviral therapy on excessive weight gain in adult treatment-naïve HIV patients at Matsanjeni health center, Eswatini: a retrospective cohort study
There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition.
Citation: AIDS Research and Therapy 2024 21:4 -
Bifocal malakoplakia in a patient living with HIV: case report
Malakoplakia is a rare chronic granulomatous disease characterized by the presence of Michaelis-Gutmann bodies (MGBs) within histiocytic aggregates. It predominantly affects immunocompromised individuals, incl...
Citation: AIDS Research and Therapy 2024 21:3 -
Empyema caused by Streptococcus constellatus in a patient infected with HIV: a case report and literature review
Empyema caused by Streptococcus constellatus (S. constellatus) is rare in patients with HIV. To analyze the clinical data of a patient living with HIV (PLHIV), who got empyema caused by S. constellatus, invest...
Citation: AIDS Research and Therapy 2024 21:2 -
Brief communications: changes in inflammatory biomarkers and lipid profiles after switching to long-acting cabotegravir plus rilpivirine
We assessed whether the impact of cabotegravir plus rilpivirine on inflammation reduction differs from that of oral antiretrovirals, using real-world data. Inflammatory biomarkers and lipid profiles were follo...
Citation: AIDS Research and Therapy 2024 21:1 -
Adolescent’s and youth’s adherence to antiretroviral therapy for better treatment outcome and its determinants: multi-center study in public health facilities
Low-adherence to Anti-retroviral therapy (ART) negatively affects the clinical, immunological, and virologic outcomes of patients. Adherence is the most important factor in determining Antiretroviral Therapy (...
Citation: AIDS Research and Therapy 2023 20:91 -
Risk factors for unsuppressed viral load after intensive adherence counseling among HIV infected persons in Kampala, Uganda: a nested case–control study
Intensive adherence counseling (IAC) is the global standard of care for people living with human immunodeficiency virus (PLHIV) who have unsuppressed VL after ≥ 6 months of first-line anti-retroviral therapy (...
Citation: AIDS Research and Therapy 2023 20:90 -
Prevalence of depression among people living with HIV in rural hospitals in South-Western Nigeria-Association with clinico-demographic factors
Major depression is the most common neuropsychiatric disorder among people living with HIV (PLWH) and is predictive of high morbidity and mortality among them. This study estimated the prevalence and explored ...
Citation: AIDS Research and Therapy 2023 20:89 -
Determinants of survival of adolescents receiving antiretroviral therapy in the Centre Region of Cameroon: a multi-centered cohort-analysis
In spite of the global decreasing mortality associated with HIV, adolescents living with HIV (ADLHIV) in sub-Saharan Africa still experience about 50% mortality rate. We sought to evaluate survival rates and d...
Citation: AIDS Research and Therapy 2023 20:88 -
Addressing HIV stigma in healthcare, community, and legislative settings in Central and Eastern Europe
Surging HIV prevalence across countries of Central and Eastern Europe (CEE) is largely a result of poor HIV care engagement and a lack of comprehensive support for key populations. This is fostered by widespre...
Citation: AIDS Research and Therapy 2023 20:87 -
Research priorities in HIV, aging and rehabilitation: building on a framework with the Canada-International HIV and Rehabilitation Research Collaborative
In 2016, the Canada-International HIV and Rehabilitation Research Collaborative established a framework of research priorities in HIV, aging and rehabilitation. Our aim was to review and identify any new emerg...
Citation: AIDS Research and Therapy 2023 20:86 -
Clinical, molecular, and histological characteristics of severely necrotic and fatal mpox in HIV-infected patients
This case series of 5 patients with severely necrotic mpox highlights the predominantly necrotic nature of lesions seen in cases of severe mpox as shown by skin and lung biopsy, as well as the extensive dissem...
Citation: AIDS Research and Therapy 2023 20:85 -
Predictors of HIV status disclosure among people living with HIV (PLHIV) in Ghana: the disclosure conundrum and its policy implications in resource limited settings
Globally, over 40 million lives have been claimed by HIV/AIDS. In Ghana, more than 350,000 people are living with HIV. Non-disclosure of HIV status is a major barrier to HIV/AIDS eradication; yet, little is kn...
Citation: AIDS Research and Therapy 2023 20:84 -
Standard of care in advanced HIV disease: review of HIV treatment guidelines in six sub-Saharan African countries
The World Health Organization (WHO) recommends an evidence-based package of care to reduce mortality and morbidity among people with advanced HIV disease (AHD). Adoption of these recommendations by national gu...
Citation: AIDS Research and Therapy 2023 20:83 -
HIV gp120/Tat protein-induced epithelial–mesenchymal transition promotes the progression of cervical lesions
Human immunodeficiency virus (HIV) infection is associated with an elevated incidence of cervical cancer, and accelerated disease progression, but the underlying mechanisms are not well understood. This study ...
Citation: AIDS Research and Therapy 2023 20:82 -
“Sex without fear”: exploring the psychosocial impact of oral HIV pre-exposure prophylaxis on gay men in England
Gay, bisexual, and other men who have sex with men (GBMSM) experience a high prevalence of psychosocial health problems, such as harmful substance use and depression, as well as being disproportionately affect...
Citation: AIDS Research and Therapy 2023 20:81 -
Qualitative study of barriers and facilitators to HIV detection and treatment among women who inject drugs during the war against Ukraine
The Russian Federation’s invasion in Ukraine has resulted social hardship, millions of internally displaced persons, the destruction of medical infrastructure, and limited access to HIV services. There is no a...
Citation: AIDS Research and Therapy 2023 20:80 -
Readmission rates in HIV-associated burkitt lymphoma patients in the USA: a nationwide readmission database (NRD) analysis
People with human immunodeficiency virus have an increased risk of developing AIDS-defining malignancies including Burkitt lymphoma. Survival outcomes in HIV-associated Burkitt lymphoma remain worse than non-H...
Citation: AIDS Research and Therapy 2023 20:79 -
Association between psychological discomforts and sleep quality among people living with HIV/AIDS
Psychological discomfort and sleep problems are considered separate disorders. Due to the high prevalence of both disorders among people living with HIV (PLWH), this study was designed to evaluate how those ch...
Citation: AIDS Research and Therapy 2023 20:78 -
Uptake of retroviral pre-exposure prophylaxis and its associated factors among female sex workers, Northwest Ethiopia
Pre-exposure prophylaxis is the use of antiretroviral medications by HIV-negative individuals to prevent infection before exposure. Ethiopia has made progress in reducing new HIV infections, but the burden rem...
Citation: AIDS Research and Therapy 2023 20:77 -
Strategies to improve the care of older adults 50 years and above living with HIV in Uganda
With effective antiretroviral therapy (ART), many persons living with HIV (PLHIV) live to old age. Caring for aged PLHIV necessitates the engagement of caregivers and patients to establish agreed-upon goals of...
Citation: AIDS Research and Therapy 2023 20:76 -
Mixed methods implementation research to understand success of intensive combination approach to roll back the epidemic in Nigerian adolescents) (iCARE Nigeria) HIV testing uptake and linkage to care among young men focusing on young men who have sex with men in Ibadan
HIV seroprevalence in Nigeria is increasing among men who have sex with men (MSM) from 14% to 2007 to 23% in 2014, threatening progress towards ending the epidemic in the country. Expanding access to HIV testi...
Citation: AIDS Research and Therapy 2023 20:75 -
Current ART, determinants for virologic failure and implications for HIV drug resistance: an umbrella review
The purpose of this study is to investigate the incidence of determinants for virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling this global public health issue is t...
Citation: AIDS Research and Therapy 2023 20:74 -
Preventative behaviours and COVID-19 infection in a Canadian cohort of people living with HIV
Few studies have examined preventative behaviour practices with respect to COVID-19 among people living with HIV (human immunodeficiency virus). Using a cross-sectional survey from a Canadian Institutes of Hea...
Citation: AIDS Research and Therapy 2023 20:73 -
The hidden effects of COVID-19 on HIV services in Zanzibar: country report
The COVID-19 pandemic has had a major effect on HIV-related healthcare services. Zanzibar has experienced several interruptions of HIV services in the areas of testing and counselling, prevention of mother-to-...
Citation: AIDS Research and Therapy 2023 20:72 -
Understanding health outcome drivers among adherence club patients in clinics of Gauteng, South Africa: a structural equation modelling (SEM) approach
There has been growing interest in understanding the drivers of health outcomes, both in developed and developing countries. The drivers of health outcomes, on the other hand, are the factors that influence th...
Citation: AIDS Research and Therapy 2023 20:71 -
Estimating prevalence and modelling correlates of HIV test positivity among female sex workers, men who have sex with men, people who inject drugs, transgender people and prison inmates in Sierra Leone, 2021
Key populations (KPs) are particularly vulnerable to HIV infection and efforts to prevent HIV infections among KPs have been less successful, largely due to existing laws and legislation that classify the grou...
Citation: AIDS Research and Therapy 2023 20:70 -
Understanding the social and structural context of oral PrEP delivery: an ethnography exploring barriers and facilitators impacting transgender women who engage in street-based sex work in Baltimore, Maryland
Transgender women who sell sex (TWSS) experience high rates of HIV acquisition. Antiretrovirals for pre-exposure prophylaxis (PrEP) represent an efficacious HIV prevention strategy. The social and structural f...
Citation: AIDS Research and Therapy 2023 20:69 -
HIV viral load suppression among people with mental disorders at two urban HIV clinics in Uganda: a parallel convergent mixed methods study using the social ecological model
Uganda adopted and implemented the Universal Test and Treat (UTT) guidelines in 2017, which require HIV-infected persons to be initiated on antiretroviral therapy (ART) at any CD4 + cell count, and to be routi...
Citation: AIDS Research and Therapy 2023 20:68