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  1. Research

    Cases of antiretroviral-associated gynaecomastia reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa

    Gynaecomastia is associated with exposure to antiretroviral therapy (ART), in particular efavirenz. There is limited data on clinical characteristics of patients with ART-associated gynaecomastia in resource-l...

    Christine Njuguna, Annoesjka Swart, Marc Blockman, Gary Maartens, Briony Chisholm, Annemie Stewart, Anri Uys and Karen Cohen

    AIDS Research and Therapy 2016 13:40

    Published on: 16 November 2016

  2. Research

    HIV sero-discordance among married HIV patients initiating anti-retroviral therapy in northern Vietnam

    In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter ...

    Vu Van Tam, Do Duy Cuong, Tobias Alfven, Ho Dang Phuc, Nguyen Thi Kim Chuc, Nguyen Phuong Hoa, Vinod Diwan and Mattias Larsson

    AIDS Research and Therapy 2016 13:39

    Published on: 15 November 2016

  3. Research

    Trends in clinical characteristics and outcomes of Pre-ART care at a large HIV clinic in Nairobi, Kenya: a retrospective cohort study

    The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even in fragile health systems. Documenting the success ...

    Jared O. Mecha, Elizabeth N. Kubo, Lucy W. Nganga, Peter N. Muiruri, Lilian N. Njagi, Immaculate N. Mutisya, Justine J. Odionyi, Syokau C. Ilovi, Mary Wambui, Christopher Githu, Richard Ngethe, Elizabeth M. Obimbo and Zipporah W. Ngumi

    AIDS Research and Therapy 2016 13:38

    Published on: 14 November 2016

  4. Research

    Re-focusing HIV prevention messages: a qualitative study in rural Uganda

    After 30 years, the human immunodeficiency virus (HIV) remains an epidemic of global concern. To support the increasing emphasis on biomedical interventions for prevention requires a renewed and reframed focus...

    Sanyukta Mathur, Dina Romo, Mariko Rasmussen, Neema Nakyanjo, Fred Nalugoda and John S. Santelli

    AIDS Research and Therapy 2016 13:37

    Published on: 11 November 2016

  5. Research

    Quasi-Poisson versus negative binomial regression models in identifying factors affecting initial CD4 cell count change due to antiretroviral therapy administered to HIV-positive adults in North–West Ethiopia (Amhara region)

    CD4 cells are a type of white blood cells that plays a significant role in protecting humans from infectious diseases. Lack of information on associated factors on CD4 cell count reduction is an obstacle for i...

    Awoke Seyoum, Principal Ndlovu and Temesgen Zewotir

    AIDS Research and Therapy 2016 13:36

    Published on: 9 November 2016

  6. Review

    Targeting vulnerable populations: a synthetic review on alcohol use and risky sexual behaviour among migrant populations

    Research has demonstrated a link between alcohol use and risky sexual behaviour among different types of migrant populations. Therefore, research investigating risk factors associated with alcohol consumption ...

    Emilia Maria Vaz Martins-Fonteyn, Nina Sommerland, Herman Meulemans, Olivier Degomme, Ines Raimundo and Edwin Wouters

    AIDS Research and Therapy 2016 13:33

    Published on: 22 September 2016

  7. Review

    Stem cell transplantation in strategies for curing HIV/AIDS

    HIV-1 can persist in a latent form in resting memory CD4+ cells and macrophages carrying an integrated copy of the HIV genome. Because of the presence of these stable reservoir cells, eradication by antiretrov...

    Gero Hütter

    AIDS Research and Therapy 2016 13:31

    Published on: 13 September 2016

  8. Review

    Dolutegravir(DTG, S/GSK1349572) combined with other ARTs is superior to RAL- or EFV-based regimens for treatment of HIV-1 infection: a meta-analysis of randomized controlled trials

    The first-generation integrase inhibitors (INIs) raltegravir (RAL) and elvitegravir (EVG) have shown efficacy against HIV infection, but they have the limitations of once-more daily dosing and extensive cross-...

    Junjun Jiang, Xi Xu, Wenqin Guo, Jinming Su, Jiegang Huang, Bingyu Liang, Hui Chen, Ning Zang, Yanyan Liao, Li Ye and Hao Liang

    AIDS Research and Therapy 2016 13:30

    Published on: 8 September 2016

  9. Research

    The effect of Tenofovir on renal function among Ugandan adults on long-term antiretroviral therapy: a cross-sectional enrolment analysis

    WHO recommends using Tenofovir containing first line antiretroviral therapy (ART), however, Tenofovir has been reported to be associated with renal impairment and dysfunction. We compared renal function among ...

    Tino Salome, Ivan Kasamba, Billy Nsubuga Mayanja, Patrick Kazooba, Jackson Were, Pontiano Kaleebu and Paula Munderi

    AIDS Research and Therapy 2016 13:28

    Published on: 30 August 2016

  10. Review

    Antiretroviral treatment regardless of CD4 count: the universal answer to a contextual question

    After a period where it was recommended to start antiretroviral therapy (ART) early, the CD4 threshold for treating asymptomatic adults dropped to 200/mm3 at the beginning of the 2000s. This was mostly due to a g...

    Serge P. Eholié, Anani Badje, Gérard M. Kouame, Jean-Baptiste N’takpe, Raoul Moh, Christine Danel and Xavier Anglaret

    AIDS Research and Therapy 2016 13:27

    Published on: 26 July 2016

  11. Research

    Plasma HIV-1 RNA viral load rebound among people who inject drugs receiving antiretroviral therapy (ART) in a Canadian setting: an ethno-epidemiological study

    People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identifie...

    Will Small, M. J. Milloy, Ryan McNeil, Lisa Maher and Thomas Kerr

    AIDS Research and Therapy 2016 13:26

    Published on: 25 July 2016

  12. Research

    Risk factors for unstructured treatment interruptions and association with survival in low to middle income countries

    Antiretroviral therapy (ART) treatment interruptions lead to poor clinical outcomes with unplanned or unstructured TIs (uTIs) likely to be underreported. This study describes; uTIs, their risk factors and asso...

    James H. McMahon, Tim Spelman, Nathan Ford, Jane Greig, Anita Mesic, Charles Ssonko, Esther C. Casas and Daniel P. O’Brien

    AIDS Research and Therapy 2016 13:25

    Published on: 11 July 2016

  13. Research

    Determinants of time to antiretroviral treatment initiation and subsequent mortality on treatment in a cohort in rural northern Malawi

    To optimise care HIV patients need to be promptly initiated on antiretroviral therapy (ART) and subsequently retained on treatment. In this study we report on the interval between enrolment and treatment initi...

    Jeremy Philip Brown, Bagrey Ngwira, Terence Tafatatha, Amelia Catharine Crampin, Neil French and Olivier Koole

    AIDS Research and Therapy 2016 13:24

    Published on: 8 July 2016

  14. Review

    Integrated therapy for HIV and tuberculosis

    Tuberculosis (TB) has been the most common opportunistic infection and cause of mortality among HIV-infected patients, especially in resource-limited countries. Clinical manifestations of TB vary and depend on...

    Weerawat Manosuthi, Surasak Wiboonchutikul and Somnuek Sungkanuparph

    AIDS Research and Therapy 2016 13:22

    Published on: 12 May 2016

  15. Review

    What happens to cardiovascular system behind the undetectable level of HIV viremia?

    Despite the combined antiretroviral therapy has improved the length and quality of life of HIV infected patients, the survival of these patients is always decreased compared with the general population. This i...

    Gabriella d’Ettorre, Giancarlo Ceccarelli, Paolo Pavone, Pietro Vittozzi, Gabriella De Girolamo, Ivan Schietroma, Sara Serafino, Noemi Giustini and Vincenzo Vullo

    AIDS Research and Therapy 2016 13:21

    Published on: 27 April 2016

  16. Short report

    Evolution of changes in cognitive function after the initiation of antiretroviral therapy

    Cognitive function is reported to improve after the initiation of combination antiretroviral therapy (cART). Data on the evolution of such changes are limited. We assessed the dynamics of changes in cognitive ...

    Borja Mora-Peris, Elizabeth Stevens, Francesca Ferretti, Jonathan Underwood, Stephen Taylor and Alan Winston

    AIDS Research and Therapy 2016 13:20

    Published on: 14 April 2016

  17. Short report

    Validation of a self-reported HIV symptoms list: the ISS-HIV symptoms scale

    To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale).

    Raffaella Bucciardini, Katherina Pugliese, Daniela Francisci, Andrea Costantini, Elisabetta Schiaroli, Miriam Cognigni, Chiara Tontini, Stefano Lucattini, Luca Fucili, Massimiliano Di Gregorio, Marco Mirra, Vincenzo Fragola, Sara Pompili, Rita Murri and Stefano Vella

    AIDS Research and Therapy 2016 13:18

    Published on: 9 April 2016

  18. Research

    Incidence and risk factors for liver enzymes elevations in highly treatment-experienced patients switching from enfuvirtide to raltegravir: a sub-study of the ANRS-138 EASIER trial

    In the ANRS EASIER trial where treatment-experienced patients switched from enfuvirtide (ENF) to raltegravir (RAL), a high incidence of transaminase elevation was reported in the RAL arm.

    Nathalie de Castro, Joséphine Braun, Isabelle Charreau, Alain Lafeuillade, Jean-Paul Viard, Clotilde Allavena, Jean-Pierre Aboulker and Jean-Michel Molina

    AIDS Research and Therapy 2016 13:17

    Published on: 2 April 2016

  19. Research

    Factors associated with HIV viral load “blips” and the relationship between self-reported adherence and efavirenz blood levels on blip occurrence: a case–control study

    The uncertain etiology of HIV viral load (VL) blips may lead to increased use of clinical resources. We evaluated the association of self-reported adherence (SRA) and antiretroviral (ART) drug levels on blip o...

    Aaron Farmer, Xun Wang, Anuradha Ganesan, Robert G. Deiss, Brian K. Agan, Thomas A. O’Bryan, Kevin Akers and Jason F. Okulicz

    AIDS Research and Therapy 2016 13:16

    Published on: 22 March 2016

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