Fig. 2From: HIV-1-related factors interact with p53 to influence cellular processesHIV-1-related factors activate p53. Vpr and tat enhance the function of p53 by upregulating miR-34a. In addition, tat also enhances p53 by phosphorylation. Furthermore, env enhances the function of p53 through the mTOR or non-mTOR pathways, or by promoting the transcription of p53. Vif promotes the function of p53Back to article page