Fig. 1From: HIV-1-related factors interact with p53 to influence cellular processesHIV-associated factors inhibit the function of p53. Nef can inhibit p53, impeding cell cycle arrest or apoptosis, dependent or independent of the Mdm2 pathway. Alternatively, nef, tat, and vpr inhibit the function of p53 via inhibiting its transcription. Furthermore, nef and tat inhibit the function of p53 via ubiquitination or mutationBack to article page