Time to start ART |
Deferred until 5 weeks after the start of antifungal therapy |
ART regimen |
Consider drug–drug interactions between fluconazole and antiretroviral agents |
Fluconazole may potentially increase PI concentrations, but no clinical significance |
Fluconazole has the potential to increase NNRTI concentration |
No significant interactions with efavirenz |
Nevirapine has the most potential clinical relevancea |
No significant interactions with rilpivirine |
Monitor closely for nevirapine-associated adverse events, including hepatotoxicity |