Table 4 Univariate and multivariate hazard ratios of the risk of treatment modification in the group of patients 30 years old to 50 years old
Parameter | Unvariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|
P value | Hazard ratio | 95 % hazard ratio confidence limits | P value | Hazard ratio | 95 % hazard ratio confidence limits | |||
Gender | ||||||||
Male | <0.001 | 1.95 | 1.40 | 2.73 | 0.034 | 1.50 | 1.03 | 2.18 |
Female | – | 1.00 | – | – | – | 1.00 | – | – |
HIV risk group | ||||||||
MSM | <0.001 | 1.71 | 1.31 | 2.23 | 0.09 | 1.29 | 0.96 | 1.72 |
Heterosexual | – | 1.00 | – | – | – | 1.00 | – | – |
IDU | 0.002 | 0.57 | 0.41 | 0.81 | 0.007 | 0.59 | 0.40 | 0.87 |
Other | 0.11 | 0.55 | 0.27 | 1.15 | 0.12 | 0.56 | 0.27 | 1.17 |
UNKN | 0.74 | 1.07 | 0.71 | 1.61 | 0.94 | 1.02 | 0.67 | 1.55 |
Nadir CD4 value | ||||||||
Per 100 increase | <0.001 | 1.46 | 1.37 | 1.56 | <0.001 | 1.44 | 1.32 | 1.57 |
Age in years | ||||||||
Per 1 year increase | 0.50 | 0.99 | 0.98 | 1.01 | 0.29 | 0.99 | 0.97 | 1.01 |
Anti-HCV Ab | ||||||||
Positive | <0.001 | 0.40 | 0.31 | 0.53 | 0.24 | 0.81 | 0.56 | 1.16 |
Negative | – | 1.00 | – | – | – | 1.00 | – | – |
Unknown | 0.45 | 0.88 | 0.63 | 1.23 | 0.06 | 1.44 | 0.98 | 2.11 |
Anti-HBc Ab | ||||||||
Positive | <0.001 | 0.60 | 0.48 | 0.76 | 0.07 | 0.79 | 0.62 | 1.02 |
Negative | – | 1.00 | – | – | – | 1.00 | – | – |
Unknown | <0.001 | 0.59 | 0.47 | 0.74 | 0.002 | 0.67 | 0.52 | 0.86 |
Baseline hemoglobin | ||||||||
Per 1 g/dL increase | 0.09 | 1.01 | 1.00 | 1.03 | 0.57 | 0.99 | 0.95 | 1.03 |
ARV group | ||||||||
PI | 0.35 | 1.11 | 0.89 | 1.38 | 0.18 | 1.16 | 0.93 | 1.46 |
NNRTI | – | 1.00 | – | – | – | 1.00 | – | – |
ITI | <0.001 | 22.9 | 9.14 | 57.5 | <0.001 | 24.7 | 9.66 | 63.4 |
FI | <0.001 | 3.85 | 2.11 | 7.02 | 0.001 | 2.73 | 1.47 | 5.04 |
Late presenter | ||||||||
Yes | <0.001 | 0.65 | 0.54 | 0.78 | 0.79 | 1.05 | 0.83 | 1.33 |