GROUP A | GROUP B | |||||||||||||||||||||||||||
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Pat-ID | #1 | #2 | #4 | #12 | #14 | #17 | #18 | #21 | #22 | #46 | #3 | #5 | #8 | #9 | #10 | #11 | #16 | #19 | #24 | #25 | #26 | #27 | #31 | #33 | #37 | #39 | #40 | #41 |
Therapy | ATV SQV RTV FTC | ATV SQV RTV 3TC | ATV SQV RTV | ATV/r SQV 3TC T20 | SQV TPV/r 3TC ddI | ddI d4T SQV | ATV SQV 3TC T20 | ATV EFV TDF AZT 3TC MVC | ATV/r SQV AZT 3TC TDF | SQV/r TDF FTC | LPV/r SQV 3TC d4T TDF | LPV/r ATV AZT 3TC | LPV/r SQV d4T | LPV/r SQV ENF | LPV ATV FTC TDF | LPV/r ATV EFV | LPV/r SQV | LPV/r SQV | APV SQV TDF | APV SQV ddC d4T | APV/r SQV | LPV/r SQV FTC TDF | LPV/r SQV 3TC ETR | LPV/r SQV AZT 3TC TDF | LPV/r SQV ddI 3TC | LPV/r SQV TDF | LPV/r SQV TDF MVC | LPV/r ATV TDF AZT ABC 3TC |
Rev.-Transcriptase mutations | 41L 44D 67N 98G 103N 118I 210F 215Y 219R | 41L 67ss 69S 188L 215Y | 41L 118I 184V 215Y | 41L 44A 67N 75I 103N 108I 118I 210W 215Y | 41L 67N 69D 70R 74V 103N 181C 210W 215F 219Q | 67N 70R 103NS 190A 184V 219Q | 41L 67N 69E 75I 103N 108I 118I 178M 210W 215Y | 41L 67N 74V 101Q 184V 215Y | 41L 44D 67N 101E 103N 118I 184V 210W 215Y 219E | n.d. | 41L 67ss 69S 101Q 181C 190S 215Y | 65R 70R 103N 108I 115F 151M 179E 184V 219E | 67N 184V 210W 215Y 219Q | 41L 44D 67N 75L 118I 181C 184V 190A 210S 215Y | 41L 44D 67N 70R 190A 227L 184V 210W 215F 219R | 41L 67N 74V 98G 118I 184V 210W 215Y 227L | 41L 44D 103N 118I 184V 210W 215Y | no data | no data | no data | 67N 70R 103S 184V 190A 215F 219Q | 41L 67N 75I 118I 210W 215F | 41L 44A 67N 75M 101Q 118I 184V 210W 215F | 41L 74V 101Q 103N 108I 181C 190A 210W 215Y | 41L 44D 67G 103N 118I 184V 210W 215F | 67N 70R 215I 219Q | 67N 70R 215I 219Q | 41L 67N 70R 184V |
Protease mutations | 10F 20I 36I 46I 50V 54I/V 76V | 10V 46I 47V 71V 76V 77I | 10V 20R 36I 46I 76V 90M | 10I 33F 46L 76V 82F 90M | 10V 20R 33F 36I 54V 73S 76V 90M | 10F 20R 46I 54V 63P 76V 82F | 10I 33F 36L 46L 76V 82F 84V 90M | 10I 53L 54V 71V 76V 77I 82A 84V 90M | 10I 33F 46L 54V 71I 76V 77L 82A 90M | 10I 33V 60E 76V | 10V 46L 54V 63P 71V 82A 93L | 10I 20I 36I 46I 54L 76V 84V | 20R 32I 46I 76V 82A | 10I 24I 33F 46I 54V 63P 71V 76V 82A | 10V 20I 36I 46I 47V 53L 76V 84V 90M | 10F 33F 46L 54L 71V 76V 77I 84V 90M | 10F 46I 54M 71V 76V 82A | 10I 20R 24I 36I 46I 54V 76V 82C | 10F 33F 54V 71V 76V 77I 82A | 10I 20R 35D 46I 54V 76V | 10I 20R 36I 46I 54V 71V 76V 82F 90M | 10I 46I 47V 71V 76V 90M | 10I 13V 32I 33F 36I 46I 76V 84V 90M | 10F 46I 47V 76V 84V | 10R 32I 33F 46I 47V 76V 84V 88S 90M | 10F 20I 36I 46I 76V 84V | 10V 13V 24I 33F 46I 54V 76V 82A | 20I 36I 54V 76V 82A |
Active Drug Scores | ||||||||||||||||||||||||||||
HIVdb 4.3.6 | [1.5] | (2.25) | 0.5 | [1.75] | 0.75 | 1,25 | [1.5] | [1.75] | 0.25 | 3.0 | 1,5 | [0.5] | [0.75] | 1.25 | 0.25 | [0.75] | [0.5] | [0.5] | 1.5 | n.d. | 0.5 | [1.25] | [0.25] | [1.5] | 0.0 | [1.0] | [1.75] | [1.75] |
Rega V7.1.1 | 2.0 | (2.75) | 1.5 | 2.0 | 1.0 | 1.0 | 2.0 | 3.5 | 0.0 | 3.0 | 1.75 | [1.0] | [1.5] | 1.0 | 0.0 | [0.25] | [0.75] | [0.75] | 1.75 | n.d. | 0.75 | [1.0] | [0.5] | 2.75 | 0.5 | 2.0 | 2.25 | 4.25 |
HIVGrade04/08 | 2.5 | (3.0) | 1.5 | 2.25 | 1.0 | 0.5 | 2.75 | 2.75 | 0.0 | 3.0 | (2.0) | [1.0] | [1.0] | (2.0) | 0.0 | [1.0] | [1.0] | [1.0] | (2.0) | n.d. | 1.0 | [1.75] | [0.0] | [1.75] | 0.0 | [0.75] | 2.0 | 2.0 |
ANRS 10/2007 | 3.0 | (2.0) | 0.5 | [1.0] | 1.0 | 1.0 | 2.0 | 2.5 | 0.5 | 3.0 | 1.5 | [0.0] | 2.0 | 1.0 | 0.5 | [1.0] | [1.0] | [0.5] | (2.0) | n.d. | 0.5 | 2.0 | [0.5] | 2.5 | 1.5 | [1.5] | 2.5 | 3.0 |
geno2pheno | 2.0 | (3.0) | 1.0 | 2.5 | (2.0) | n.d. | n.d. | 2.0 | n.d. | 3.0 | (2.0) | [0.5] | [0.5] | 1.5 | 0.0 | [1.0] | n.d. | n.d. | n.d. | n.d. | 0.0 | 2.5 | n.d. | 2.0 | 0.0 | 1.0 | 2.0 | 4.0 |
VircoType | 2.25 | (2.0) | (2.0) | 2.5 | 1.5 | n.d. | n.d. | 3.5 | n.d. | 3.0 | 2.5 | 2.0 | 2.0 | 1.0 | 0.5 | [0.5] | [1.0] | [1.0] | n.d. | n.d. | 0.5 | [1.0] | [1.0] | 3.0 | 1.5 | 2.0 | 3.0 | 3.5 |
Phenotype | 2.5 | n.d. | 0.0 | n.d. | n.d. | (3.0) | 3.0 | 3.0* | n.d. | n.d. | n.d. | 2.5 | 2.5 | (2.0) | n.d. | n.d. | n.d. | [0.5] | n.d. | n.d. | 0.0 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. |
Follow-up | ||||||||||||||||||||||||||||
Baseline VL | 1070 | 160000 | 26900 | 3231 | 47653 | 859000 | 7700 | 27000 | 35400 | 4248 | 6680 | 25900 | 4840 | 31400 | 39000 | 20163 | 8751 | 8800 | 88100 | 16100 | 310510 | < 50 | 72100 | 14900 | 1300 | 744 | 2078 | 443 |
Lowest VL (12-96 weeks) | < 50 | 3410 | 38700 | < 50 | 4943 | 190 | < 50 | < 50 | 1020 | < 50 | 1320 | < 50 | < 50 | 116 | 24000 | < 50 | < 50 | < 50 | 559 | < 50 | 18270 | < 50 | < 50 | < 50 | 1300 | < 50 | < 50 | < 50 |
VL at week 96 | 13589 | 46570 | 152000 | < 50 | 20626 | LFU | LFU | LFU | 16500 | LFU | LFU | < 50 | < 50 | 116 | LFU | < 50 | < 50 | LFU | LFU | 1777 | LFU | 391 | 60 | < 50 | LFU | < 50 | < 50 | < 50 |