| | HIV-1BaL | HIV-1NDK |
|---|
| |
NonOps
|
HI NonOps
|
Ops
|
NonOps
|
HI NonOps
|
Ops
|
Lf
| I (30%)* | I (26%) | NI [S]** | I (63%) | I (61%) | I (26%) [S] |
CADA
| I (61%) | I (64%) | NI [S] | I (95%) | I (93%) | I (96%) |
T20
| I (83%) | I (82%) | I (57%) [S] | I (95%) | I (95%) | I (97%) |
IgG1B12
| I (86%) | I (85%) | I (60%) [S] | I (94%) | I (96%) | I (94%) |
IgG12G5
| NI | NI | NI | I (95%) | I (95%) | I (54%) [S] |
IgG2G12
| I (67%) | I (62%) | I (69%) | I (96%) | I (95%) | I (96%) |
IgG2F5
| I (84%) | I (77%) | I (41%) [S] | I (97%) | I (96%) | I (97%) |
Ab to gp160***
| I (61%) | I (58%) | I (50%) [S] | I (79%) | I (91%) | I (69%) |
- * Percentage of virus production inhibition in brackets
- ** Significant difference between the percentages of production inhibition is significant according to Ops, HI NonOps and NonOps HIV-1 (Mann & Whitney U test)
- *** Used as positive control
- NonOps: Non opsonized free HIV-1; HI NonOps: Heat inactivated non opsonized free HIV-1; Ops: Free HIV-1 opsonized virus by complement components
- I: Virus production inhibition; NI: Lack of transcytosis inhibition
- S: Significant
- The infection inhibition is shown for the best doses of the candidate molecules, and is expressed as percentage of the average of three independent experiments. The range of detected HIV-1 p24 antigen for uninhibited HIV-1 replication in negative control experimentations (without microbicide molecules) was 800-1000 pg/ml in iMDDC infectivity assay. The capability of dendritic cells to replicate HIV-1 is donor-dependent.
