Skip to main content

Table 3 Increase in AZT-induced % Inhibition of HIV-1 replication by the addition of non-toxic doses of WR1065a

From: Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo

Expt. Number

% HIV-1 Inhibition WR1065 alone (Concentration)

% HIV-1 Inhibition AZT alone (Concentration)

% HIV-1 Inhibition AZT + WR1065

Increase in % inhibition HIV-1 with added WR1065 a

1

65.2%

(26.0 μM)

71.8%

(1.9 ηM)

86.6%

14.8%

2

20.0%

(26.0 μM)

38.8%

(1.9 ηM)

61.4%

29.9%

3

67.4%

(18.5 μM)

31.5%

(2.2 ηM)

81.9%

50.4%

  1. a In each experiment two identical AZT standard curves for inhibition of virus replication were compared; one curve had 1.9-23.0 ηM AZT alone and the second curve had 1.9-23.0 ηM AZT plus a constant non-toxic amount (see table) of WR1065 added to each AZT concentration. The only informative concentrations of AZT were the 1.9 and 2.2 ηM doses that alone gave % Inhibition values well below 80%. A representative set of curves (experiment 3) including all points is shown in Figure 2.
Back to article page

AIDS Research and Therapy

ISSN: 1742-6405

Contact us