Table 1 Anti-HIV activity (EC₅₀) and cytotoxicity(LC₅₀) data of R.I.CK-Tat9 based bioconjugates in MT-2 cell culture infected with HIV-1 strain LAV-Vbu3 (MOI of 0.01)^a.

L-Tat9

-

51.3

-

53.8

1

R.I.CK-Tat9

1

0.85

-

29.8

35

R.I.CK(biotin)-Tat9

2

0.018

0.02

46.8

2600

PEG_{10 K}-(R.I.CK-Tat9)₈

8

1.47

1.7

29.1

20

PEG_{10 K}-(R.I.CK(biotin)-Tat9)₈

9

1.50

1.8

29.7

20

SQV(MeSO₃H) (control)

12

0.015

-

25

1667

SQV-Cys-PEG_{3.4 K}

14

0.90

60

4.5

50

SQV-Cys(R.I.CK-Tat9)-PEG_{3.4 K}

15

0.015

1

12.5

833