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  1. The nucleoside(tide) reverse transcriptase inhibitors (NRTIs) have traditionally been an important ‘back-bone’ of an antiretroviral therapy (ART) regimen. However all agents have been associated with both shor...

    Authors: Amit C Achhra and Mark A Boyd
    Citation: AIDS Research and Therapy 2013 10:33
  2. The success of highly active antiretroviral therapy (HAART) has determined a dramatic decline in AIDS- and immunodeficiency-related causes of death in the HIV-infected population. As life-expectancy increases,...

    Authors: Adelzon A Paula, Melissa CN Falcão and Antonio G Pacheco
    Citation: AIDS Research and Therapy 2013 10:32
  3. Thirty years since the discovery of HIV, the HIV pandemic in sub-Saharan Africa accounts for more than two thirds of the world’s HIV infections. Southern Africa remains the region most severely affected by the...

    Authors: Gita Ramjee and Brodie Daniels
    Citation: AIDS Research and Therapy 2013 10:30
  4. Anti-retroviral treated HIV-infected patients are at risk of mitochondrial toxicity, but non-invasive markers are lacking. Serum FGF-21 (fibroblast growth factor 21) levels correlate strongly with muscle biops...

    Authors: Brendan AI Payne, David Ashley Price and Patrick F Chinnery
    Citation: AIDS Research and Therapy 2013 10:27
  5. CCR5-delta32 heterozygous individuals are susceptible to HIV-1. However, it is not clear if there is a relevant protective effect against transmission and a beneficial effect in terms of HIV progression which ...

    Authors: Gero Hütter, Christian Blüthgen, Martin Neumann, Mark Reinwald, Daniel Nowak and Harald Klüter
    Citation: AIDS Research and Therapy 2013 10:26
  6. Early recognition of antiretroviral therapy (ART) failure in resource limited settings is a challenge given the limited laboratory facilities and trained personnel. This study aimed at describing the incidence...

    Authors: Robert Sebunya, Victor Musiime, Sabrina Bakeera Kitaka and Grace Ndeezi
    Citation: AIDS Research and Therapy 2013 10:25
  7. The enumeration of absolute CD4 counts is of primary importance for many medical conditions especially HIV infection where therapeutic initiation depends on the count. These ranges tend to vary across populati...

    Authors: Erick M Bosire, Anthony K Nyamache, Michael M Gicheru, Samoel A Khamadi, Raphael W Lihana and Vincent Okoth
    Citation: AIDS Research and Therapy 2013 10:24
  8. Although the Centres for disease Control and Prevention (CDC) recommends empiric treatment for schistosomiasis and strongyloidiasis (prevalent but treatable parasitic infections) in some refugee groups it is u...

    Authors: Corinna M Sadlier, Aisling Brown, John S Lambert, Gerard Sheehan and Patrick W G Mallon
    Citation: AIDS Research and Therapy 2013 10:23
  9. Susac’s Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of pla...

    Authors: Francesca Ferretti, Simonetta Gerevini, Bruno Colombo, Manuela Testa, Monica Guffanti, Diego Franciotta, Gaetano Bernardi, Adriano Lazzarin and Paola Cinque
    Citation: AIDS Research and Therapy 2013 10:22
  10. Increasing rates of non-AIDS defining illnesses, and in particular liver diseases, have been found after the initiation of highly active antiretroviral therapy. However, there is little evidence concerning the...

    Authors: Thep Chalermchai, Narin Hiransuthikul, Pisit Tangkijvanich, Suteeraporn Pinyakorn, Anchalee Avihingsanon and Jintanat Ananworanich
    Citation: AIDS Research and Therapy 2013 10:21
  11. Antiretroviral therapy (ART) roll-out is fraught with challenges, many with serious repercussions. We explored and described patient behaviour-related challenges from the perspective of health care providers f...

    Authors: Janet Michel, Christina Matlakala, Rene English, Richard Lessells and Marie-Louise Newell
    Citation: AIDS Research and Therapy 2013 10:20
  12. Tuberculosis (TB) disease affects survival among HIV co-infected patients on antiretroviral therapy (ART). Yet, the magnitude of TB disease on mortality is poorly understood.

    Authors: Rong Chu, Edward J Mills, Joseph Beyene, Eleanor Pullenayegum, Celestin Bakanda, Jean B Nachega, P J Devereaux and Lehana Thabane
    Citation: AIDS Research and Therapy 2013 10:19
  13. HIV/TB coinfection remains a major challenge even after the initiation of HAART. Little is known about Mycobacterium tuberculosis (Mtb) specific immune restoration in relation to immunologic and virologic outcome...

    Authors: Desta Kassa, Gebremedhin Gebremichael, Yodit Alemayehu, Dawit Wolday, Tsehaynesh Messele and Debbie van Baarle
    Citation: AIDS Research and Therapy 2013 10:18
  14. The prevention of intimate partner transmission of HIV remains an important component of comprehensive HIV prevention strategies. In this paper we examine the sexual practices of people living with HIV on anti...

    Authors: Wing Young Nicola Man, Angela Kelly, Heather Worth, Andrew Frankland, Patti Shih, Martha Kupul, Thiri Lwin, Agnes Mek, Barbara Kepa, Rebecca Emori, Frances Akuani, Brenda Cangah, Lucy Walizopa, Lawrencia Pirpir, Somu Nosi and Peter M Siba
    Citation: AIDS Research and Therapy 2013 10:17
  15. Tuberculous meningitis (TBM) the most fatal presentation of tuberculosis (TB) especially in HIV-infected patients is a real diagnostic and therapeutic challenge worldwide. In Cameroon where HIV and TB are amon...

    Authors: Henry Namme Luma, Benjamin Clet Nguenkam Tchaleu, Bertrand Hugo Mbatchou Ngahane, Elvis Temfack, Marie Solange Doualla, Marie Patrice Halle, Henry Achu Joko and Sinata Koulla-Shiro
    Citation: AIDS Research and Therapy 2013 10:16
  16. Resistance to CCR5 inhibitors, such as maraviroc and vicriviroc is characterized by reduction of maximal percent inhibition which indicates the use of an inhibitor-bound conformation of CCR5 for human immunode...

    Authors: Odalis Asin-Milan, Annie Chamberland, Yi Wei, Alpha Haidara, Mohamed Sylla and Cécile L Tremblay
    Citation: AIDS Research and Therapy 2013 10:15
  17. CSIC (5-chloro-3-phenylsulfonylindole-2-carboxamide), a non-nucleoside reverse transcriptase inhibitor (NNRTI) has not been advanced as a therapeutic anti-HIV candidate drug due to its low aqueous solubility a...

    Authors: Nicholas C Obitte, Lisa C Rohan, Christianah M Adeyeye, Michael A Parniak and Charles O Esimone
    Citation: AIDS Research and Therapy 2013 10:14
  18. Despite the increasingly wider availability of antiretroviral therapy (ART), some people living with HIV (PLHIV) and eligible for treatment have opted to adopt self-care practices thereby risking early AIDS-re...

    Authors: Maurice Musheke, Virginia Bond and Sonja Merten
    Citation: AIDS Research and Therapy 2013 10:12
  19. Chemokines can block viral entry by interfering with HIV co-receptors and are recognised mediators of atherosclerosis development. A number of experimental drugs that inhibit HIV entry arrest the development o...

    Authors: Laura Fernández-Sender, Carlos Alonso-Villaverde, Anna Rull, Esther Rodríguez-Gallego, Marta Riera-Borrull, Anna Hernández-Aguilera, Jordi Camps, Raúl Beltrán-Debón, Gerard Aragonès, Javier A Menendez and Jorge Joven
    Citation: AIDS Research and Therapy 2013 10:11
  20. The prevalence of human immunodeficiency virus (HIV) continues to increase among certain populations including young men who have sex with men (MSM). College campuses represent a potential setting to engage yo...

    Authors: Nilay Patel, Aadia Rana, Alyssa Thomas, John C Barnhart, Timothy P Flanigan, Jacob J van den Berg and Philip A Chan
    Citation: AIDS Research and Therapy 2013 10:8
  21. A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers whose efforts often go unrecognized. AIDS Research and Therapy has been blessed by the support of highl...

    Authors: Kailash Gupta
    Citation: AIDS Research and Therapy 2013 10:6
  22. Intestinal parasites are a major concern in most developing countries where HIV/AIDS case are concentrate and almost 80% of AIDS patients die of AIDS-related infections. In the absence of ART, HIV/AIDS patient...

    Authors: Assefa Missaye, Mulat Dagnew, Abebe Alemu and Agersew Alemu
    Citation: AIDS Research and Therapy 2013 10:7
  23. HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection. NGX-4010 is a capsaicin 8% dermal patch with demonstrated efficacy ...

    Authors: Stephen Brown, David M Simpson, Graeme Moyle, Bruce J Brew, Giovanni Schifitto, Nicholas Larbalestier, Chloe Orkin, Martin Fisher, Geertrui F Vanhove and Jeffrey K Tobias
    Citation: AIDS Research and Therapy 2013 10:5
  24. The objective of this work was to study the virological outcomes associated with two different types of treatment interruption strategies in patients with allergic reactions to nevirapine (NVP). We compared th...

    Authors: Krittaecho Siripassorn, Weerawat Manosuthi, Aranya Pakdee, Sunanta Natprom, Anuttra Chaovavanich, Narongsak Hengphadpanadamrong, Khobchok Woratanarat, Aroon Lueangniyomkul and Kiat Ruxrungtham
    Citation: AIDS Research and Therapy 2013 10:4
  25. While the introduction of combination highly active antiretroviral therapy (HAART) regimens represents an important advance in the management of human immunodeficiency virus (HIV)-infected patients, tolerabili...

    Authors: José R Arribas, Manuela Doroana, Dan Turner, Linos Vandekerckhove and Adrian Streinu-Cercel
    Citation: AIDS Research and Therapy 2013 10:3
  26. Despite progress in the development of combined antiretroviral therapies (cART), HIV infection remains a significant challenge for human health. Current problems of cART include multi-drug-resistant virus vari...

    Authors: Maria M Prokofjeva, Kristoffer Riecken, Pavel V Spirin, Dimitriy V Yanvarév, Arne Düsedau, Bernhard Ellinger, Boris Fehse, Carol Stocking and Vladimir S Prassolov
    Citation: AIDS Research and Therapy 2013 10:1
  27. The relationship between HIV serostatus disclosure and sexual risk behavior is inconsistent across studies. As men who have sex with men (MSM) are emerging as the key affected population in Bangkok, Thailand w...

    Authors: Nneka Edwards-Jackson, Nittaya Phanuphak, Hong Van Tieu, Nitiya Chomchey, Nipat Teeratakulpisarn, Wassana Sathienthammawit, Charnwit Pakam, Nutthasun Pharachetsakul, Magdalena E Sobieszczyk, Praphan Phanuphak and Jintanat Ananworanich
    Citation: AIDS Research and Therapy 2012 9:38
  28. The benefits of antiretroviral therapy (ART) cannot be experienced if they are not taken as prescribed. Yet, not all causes of non-adherence are dependent on the patient. Having to pay for medication reduces a...

    Authors: Lawrence Mbuagbaw, Lehana Thabane, Pierre Ongolo-Zogo, David Yondo, Stephen Noorduyn, Marek Smieja and Lisa Dolovich
    Citation: AIDS Research and Therapy 2012 9:37
  29. Peripheral neuropathy (PN) which is the most common neurological complication of HIV infection is under recognised and undertreated especially in resource limited settings. This ailment which has a negative im...

    Authors: Henry Namme Luma, Benjamin Clet Nguenkam Tchaleu, Marie Solange Doualla, Elvis Temfack, Victor Nicolas King Sopouassi, Yacouba Njankouo Mapoure and Vincent-de-Paul Djientcheu
    Citation: AIDS Research and Therapy 2012 9:35
  30. Human APOBEC3G is a host defense factor that potently inhibits HIV replication. We hypothesize that HIV-infected children with a genetic variant of APOBEC3G will have a more rapid disease progression.

    Authors: Torsak Bunupuradah, Mayumi Imahashi, Thatri Iampornsin, Kazuhiro Matsuoka, Yasumasa Iwatani, Thanyawee Puthanakit, Jintanat Ananworanich, Jiratchaya Sophonphan, Apicha Mahanontharit, Tomoki Naoe, Saphonn Vonthanak, Praphan Phanuphak and Wataru Sugiura
    Citation: AIDS Research and Therapy 2012 9:34
  31. Whilst there have been studies on the risks and outcomes of MRSA colonization and infections in HIV-positive patients, local data is limited on the risk factors for MRSA colonization among these patients. We u...

    Authors: Win Mar Kyaw, Linda Kay Lee, Wong Chia Siong, Angela Chow Li Ping, Brenda Ang and Yee Sin Leo
    Citation: AIDS Research and Therapy 2012 9:33
  32. Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor in resource-limited settings, often ca...

    Authors: Phumla Z Sinxadi, Helen M McIlleron, Joel A Dave, Peter J Smith, Naomi S Levitt and Gary Maartens
    Citation: AIDS Research and Therapy 2012 9:32
  33. Data on lipid profile abnormalities among patients receiving highly active antiretroviral treatment in Ethiopia are very limited. The aim of this study was to determine the prevalence of dyslipidemia and chara...

    Authors: Agete Tadewos, Zelalem Addis, Henock Ambachew and Sandip Banerjee
    Citation: AIDS Research and Therapy 2012 9:31
  34. Opiate substitution treatment has been associated with better adherence to lifesaving antiretroviral medications, but the impact of other substance abuse treatment on adherence is unknown.

    Authors: Marc I Rosen, Anne C Black, Julia H Arnsten, Jane M Simoni, Glann J Wagner, Kathleen Goggin, Robert H Remien, Carol E Golin, Yan Wang, David Bangsberg and Honghu H Liu
    Citation: AIDS Research and Therapy 2012 9:30
  35. Metabolic Syndrome (MetS) is based on the same individual components, but has received several amendments to the original definition. In this study, we verified the prevalence of metabolic syndrome according t...

    Authors: Paulo R Alencastro, Fernando H Wolff, Renato R Oliveira, Maria Letícia R Ikeda, Nêmora T Barcellos, Ajácio B M Brandão and Sandra C Fuchs
    Citation: AIDS Research and Therapy 2012 9:29
  36. HIV infection among children, particularly those under 24 months of age, is often rapidly progressive; as a result guidelines recommend earlier access to combination antiretroviral therapy (cART) for HIV infec...

    Authors: Uduak Okomo, Toyin Togun, Francis Oko, Kevin Peterson and Assan Jaye
    Citation: AIDS Research and Therapy 2012 9:28
  37. The impact of highly active antiretroviral therapy (HAART) in HIV-infected patients admitted to the intensive care unit (ICU) remains controversial. We evaluate impact of HAART prescription in HIV-infected pat...

    Authors: Agnes Meybeck, Lydie Lecomte, Michel Valette, Nicolas Van Grunderbeeck, Nicolas Boussekey, Arnaud Chiche, Hugues Georges, Yazdan Yazdanpanah and Olivier Leroy
    Citation: AIDS Research and Therapy 2012 9:27
  38. In resource limited settings non-availability of CD4 count facility at the site could adversely affect the ART roll out programme. Point of care CD4 enumerating equipments can make the CD4 count available at t...

    Authors: Madhuri Thakar, Bharati Mahajan, Nawaj Shaikh, Salman Bagwan, Suvarna Sane, Sandhya Kabra, Bharat Rewari, Mohamad Shaukat, Namita Singh, Peter Trevor and Ramesh Paranjape
    Citation: AIDS Research and Therapy 2012 9:26
  39. The true prevalence of HIV and other sexually transmitted diseases among street children in Nepal is virtually unknown while information on related behavioural risk factors in this population is non-existent. ...

    Authors: Dibesh Karmacharya, Dongmei Yu, Sameer Dixit, Rajesh Rajbhandari, Bhawana Subedi, Sonu Shrestha, Sulochana Manandhar and Susan L Santangelo
    Citation: AIDS Research and Therapy 2012 9:25
  40. This study reports the clinical characteristics and outcome of HIV-associated Penicilliummarneffei infection in northern Vietnam.

    Authors: Mattias Larsson, Lien Ha Thi Nguyen, Heiman FL Wertheim, Trinh Tuyet Dao, Walter Taylor, Peter Horby, Trung Vu Nguyen, Minh Ha Thi Nguyen, Thuy Le and Kinh Van Nguyen
    Citation: AIDS Research and Therapy 2012 9:24
  41. The 2012 International Symposium on HIV and Emerging Infectious Diseases (ISHEID) provided a forum for investigators to hear the latest research developments in the clinical management of HIV and HCV infection...

    Authors: Alain Lafeuillade, Vicente Soriano, Marie Suzan-Monti, Mario Stevenson, Jacques Izopet and Hans-Jürgen Stellbrink
    Citation: AIDS Research and Therapy 2012 9:23
  42. CCR5 antagonists have clinically been approved for prevention or treatment of HIV/AIDS. Countries in Sub-Saharan Africa with the highest burden of HIV/AIDS are due to adopt these regimens. However, HIV-1 can a...

    Authors: Veronica Wambui, Michael Kiptoo, Joyceline Kinyua, Irene Odera, Edward Muge, Peter Muiruri, Raphael Lihana, Peter Kinyanjui and Elijah M Songok
    Citation: AIDS Research and Therapy 2012 9:22