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  1. We report a rare case of osteonecrosis of the jaw following necrotizing gingivitis in a Japanese AIDS patient. Intraoral examination showed exposed necrotic bone in the left mandible and spontaneous loss of te...

    Authors: Yusuke Zushi, Kazuma Noguchi, Kuniyasu Moridera, Kazuki Takaoka and Hiromitsu Kishimoto
    Citation: AIDS Research and Therapy 2015 12:13
    Content type: Case report Published on:

  2. New evidence has emerged regarding when to commence antiretroviral therapy (ART), optimal treatment regimens, management of HIV co-infection with opportunistic infections, and management of ART failure. The 20...

    Authors: Weerawat Manosuthi, Sumet Ongwandee, Sorakij Bhakeecheep, Manoon Leechawengwongs, Kiat Ruxrungtham, Praphan Phanuphak, Narin Hiransuthikul, Winai Ratanasuwan, Ploenchan Chetchotisakd, Woraphot Tantisiriwat, Sasisopin Kiertiburanakul, Anchalee Avihingsanon, Akechittra Sukkul and Thanomsak Anekthananon
    Citation: AIDS Research and Therapy 2015 12:12
    Content type: Review Published on:

  3. An HIV-1 tropism test is recommended prior to CCR5 antagonist administration to exclude patients harboring non-R5 virus from treatment with this class of antiretrovirals. HIV-1 tropism determination based on p...

    Authors: Russell E Baumann, Amy A Rogers, Hasnah B Hamdan, Harold Burger, Barbara Weiser, Wei Gao, Kathryn Anastos, Mary Young, William A Meyer III, Rick L Pesano and Ron M Kagan
    Citation: AIDS Research and Therapy 2015 12:11
    Content type: Research Published on:

  4. Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevir...

    Authors: Margaret Ngwono Oluka, Faith Apolot Okalebo, Anastasia Nkatha Guantai, R Scott McClelland and Susan M Graham
    Citation: AIDS Research and Therapy 2015 12:10
    Content type: Research Published on:

  5. MDD and HIV/AIDS have a high prevalence worldwide with severe consequences for patients. In both conditions, compliance with treatment is key to successfully treat these disorders. In the current study, we exa...

    Authors: Francois N Slabbert, Brian H Harvey, Christiaan B Brink and Martie S Lubbe
    Citation: AIDS Research and Therapy 2015 12:9
    Content type: Research Published on:

  6. Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease...

    Authors: José Ignacio López De León, Jose Antonio Mata-Marín, Karen Andrade-Fuentes, Gloria Huerta-Garcia, Juan C Domínguez-Hemosillo and Jesus Gaytán-Martínez
    Citation: AIDS Research and Therapy 2015 12:8
    Content type: Research Published on:

  7. Antimalarials quinacrine (Qc) and chloroquine (Cq) intercalate DNA, potentiate the activity of other drugs and have lysosomotropic, anti-inflammatory and antiviral activities that could increase the effect of ...

    Authors: Klintsy J Torres, Gustavo Reyes-Terán, Julio Sotelo, Helgi Jung-Cook and Lucinda Aguirre-Cruz
    Citation: AIDS Research and Therapy 2015 12:7
    Content type: Short report Published on:

  8. Antiretroviral treatment (ART) has been effective in reducing HIV/AIDS related morbidity and mortality. However, the use and uptake of ART has resulted in adverse reactions, due mainly to the medicine’s toxici...

    Authors: Lieketseng J Masenyetse, Samuel OM Manda and Henry G Mwambi
    Citation: AIDS Research and Therapy 2015 12:6
    Content type: Research Published on:

  9. The emergence of transmitted drug resistance (TDR) compromises the effect of antiretroviral therapy (ART), resulting in treatment failure of human immunodeficiency virus (HIV) disease. Although more than a dec...

    Authors: Tomohiro Kotaki, Siti Qamariyah Khairunisa, Adiana Mutamsari Witaningrum, Muhammad Qushai Yunifiar M, Septhia Dwi Sukartiningrum, Muhammad Noor Diansyah, Retno Pudji Rahayu, Nasronudin and Masanori Kameoka
    Citation: AIDS Research and Therapy 2015 12:5
    Content type: Research Published on:

  10. HIV infection may be associated with an increased recurrence rate of myocardial infarction. Our aim was to determine whether HIV infection is a risk factor for worse outcomes in patients with coronaray artery ...

    Authors: David Carballo, Cécile Delhumeau, Sebastian Carballo, Caroline Bähler, Dragona Radovanovic, Bernard Hirschel, Olivier Clerc, Enos Bernasconi, Dominique Fasel, Patrick Schmid, Alexia Cusini, Jan Fehr, Paul Erne, Pierre-Fréderic Keller, Bruno Ledergerber and Alexandra Calmy
    Citation: AIDS Research and Therapy 2015 12:4
    Content type: Research Published on:

  11. The availability of HIV antiretroviral therapy (ART) has been associated with the development of transmitted drug resistance-associated mutations (TDRM). TDRM can compromise treatment effectiveness in patients...

    Authors: Awachana Jiamsakul, Sunee Sirivichayakul, Rossana Ditangco, Ka-Hing Wong, Patrick CK Li, Jutarat Praparattanapan, Praphan Phanuphak, Edelwisa Segubre-Mercado, Wing-Cheong Yam, Thira Sirisanthana, Thida Singtoroj and Matthew Law
    Citation: AIDS Research and Therapy 2015 12:3
    Content type: Short report Published on:

  12. The Human Immune Deficiency Virus (HIV) can manifest neurologically in both adults and children. Early invasion of the central nervous system by the virus, affecting the developing brain, is believed to result...

    Authors: Kirsten A Donald, Kathleen G Walker, Tracy Kilborn, Henri Carrara, Nelleke G Langerak, Brian Eley and Jo M Wilmshurst
    Citation: AIDS Research and Therapy 2015 12:2
    Content type: Research Published on:

  13. While HIV, AIDS and atypical Mycobacterium infections are closely linked, the use of Integrase-Inhibitor based cART, notably raltegravir-based regimens is more widespread. RAL should be double-dosed to 800 mg ...

    Authors: Christoph D Spinner, Florian Wille, Christiane Schwerdtfeger, Philipp Thies, Ursula Tanase, Guido Von Figura, Roland M Schmid, Werner J Heinz and Hartwig Hf Klinker
    Citation: AIDS Research and Therapy 2015 12:1
    Content type: Short report Published on:

  14. Treatments in patients with multidrug resistance often involve the use of multiple agents with partial antiviral activity and overlapping metabolic toxicities. Enfuvirtide is therefore a welcome addition to th...

    Authors: Gloria Huerta-García, Marcelino Chavez-García, José Antonio Mata-Marín, Jorge Sandoval-Ramírez, Juan Domínguez-Hermosillo, Ana Lourdes Rincón-Rodríguez and Jesús Gaytán-Martínez
    Citation: AIDS Research and Therapy 2014 11:323
    Content type: Research Published on:

  15. Cobicistat is an alternative pharmacoenhancer to ritonavir. In healthy volunteers, darunavir exposure was comparable when darunavir 800 mg once daily was co-administered with cobicistat 150 mg once daily (as s...

    Authors: Karen Tashima, Gordon Crofoot, Frank L Tomaka, Thomas N Kakuda, Anne Brochot, Tom Van de Casteele, Magda Opsomer, William Garner, Nicolas Margot, Joseph M Custodio, Marshall W Fordyce and Javier Szwarcberg
    Citation: AIDS Research and Therapy 2014 11:39
    Content type: Research Published on:

  16. Abnormal NK phenotype and cytotoxic functions have been described in acute myeloid leukemia, chronic lymphocytic leukemia, myeloma and myelodysplastic syndromes. Defective NK cytotoxicity is due to decreased e...

    Authors: Delphine Mercier-Bataille, Carole Sanchez, Céline Baier, Thérèse Le Treut, Nicolas Mounier, Saadia Mokhtari, Daniel Olive, Karine Baumstarck, Gérard Sébahoun, Caroline Besson and Régis T Costello
    Citation: AIDS Research and Therapy 2014 11:38
    Content type: Research Published on:

  17. We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria t...

    Authors: Robertas Samalavicius, Mindaugas Serpytis, Donata Ringaitiene, Daiva Grazulyte, Ruta Bertasiute, Bernardas Rimkus, Raimonda Matulionyte, Ruta Ambrazaitiene, Jurate Sipylaite, Tomas Kacergius and Laimonas Griskevicius
    Citation: AIDS Research and Therapy 2014 11:37
    Content type: Case report Published on:

  18. We built a cohort study of HIV patients taking long-term first-line Antiretroviral Therapy in 2003. In this assay, we focused on the development of primary drug resistance mutations against Non-Nucleoside Reve...

    Authors: Yuncong Wang, Hui Xing, Lingjie Liao, Zhe Wang, Bin Su, Quanbi Zhao, Yi Feng, Pengfei Ma, Jia Liu, Jianjun Wu, Yuhua Ruan and Yiming Shao
    Citation: AIDS Research and Therapy 2014 11:36
    Content type: Research Published on:

  19. A number of antiviral agents used against Human Immunodeficiency Virus (HIV) infection and hepatitis B virus (HBV) mono or co-infection have been associated with real nephrotoxicity (including tenofovir disopr...

    Authors: Stephen G Holt, David M Gracey, Miriam T Levy, David W Mudge, Ashley B Irish, Rowan G Walker, Richard Baer, Jacob Sevastos, Riaz Abbas and Mark A Boyd
    Citation: AIDS Research and Therapy 2014 11:35
    Content type: Review Published on:

  20. We report a 57-year old man with diabetes mellitus and hypertension who presented with acute HIV infection. Routine blood tests showed an elevated blood urea nitrogen and creatinine. Renal biopsy showed acute ...

    Authors: Jintanat Ananworanich, Anandita A Datta, James LK Fletcher, Natavudh Townamchai, Nitiya Chomchey, Eugene Kroon, Irini Sereti, Victor Valcour and Jerome H Kim
    Citation: AIDS Research and Therapy 2014 11:34
    Content type: Case report Published on:

  21. Ongoing HIV-1 replication in lymphoid cells is one explanation of the persistence of HIV-1 reservoirs despite highly active antiretroviral therapy (cART). We tested the potential of cART intensification by Mar...

    Authors: Alain Lafeuillade, Assi Assi, Cécile Poggi, Caroline Bresson-Cuquemelle, Eric Jullian and Catherine Tamalet
    Citation: AIDS Research and Therapy 2014 11:33
    Content type: Research Published on:

  22. Increasing numbers of HIV-infected patients in sub-Saharan Africa are exposed to antiretroviral therapy (ART), but there are few data on lipid changes on first-line ART, and even fewer on second-line.

    Authors: Zvenyika AR Gomo, James G Hakim, Sarah A Walker, Willard Tinago, Gibson Mandozana, Cissy Kityo, Paula Munderi, Elly Katabira, Andrew Reid, Diana M Gibb and Charles F Gilks
    Citation: AIDS Research and Therapy 2014 11:32
    Content type: Research Published on:

  23. Sexually transmitted infections (STIs) contribute largely to the burden of health in South Africa and are recognized as major contributors to the human immunodeficiency virus (HIV) epidemic. Young women are pa...

    Authors: Sarita Naidoo, Handan Wand, Nathlee Samantha Abbai and Gita Ramjee
    Citation: AIDS Research and Therapy 2014 11:31
    Content type: Short report Published on:

  24. The CD5 protein antagonizes phosphorylation events downstream of T cell receptor (TCR) engagement to decrease T cell responsiveness. CD5-negative T cell clones respond preferentially over their CD5+ counterparts ...

    Authors: Stephen J Penney, Maureen E Gallant and Michael D Grant
    Citation: AIDS Research and Therapy 2014 11:30
    Content type: Research Published on:

  25. While Brazil has had a long-standing policy of free access to antiretroviral therapy (ART) for all in need, the epidemiological impact of ART on human immunodeficiency virus (HIV) RNA suppression in this middl...

    Authors: Sandra W Cardoso, Paula M Luz, Luciane Velasque, Thiago Torres, Lara Coelho, Kenneth A Freedberg, Valdilea G Veloso, Rochelle P Walensky and Beatriz Grinsztejn
    Citation: AIDS Research and Therapy 2014 11:29
    Content type: Research Published on:

  26. The 2014 International Symposium on HIV and Emerging Infectious Diseases (ISHEID) provided a forum for investigators to hear the latest research developments in the clinical management of HIV and HCV infection...

    Authors: Alain Lafeuillade, Mark Wainberg, Marie-Lise Gougeon, Sabine Kinloch-de Loes, Philippe Halfon and Hervé Tissot-Dupont
    Citation: AIDS Research and Therapy 2014 11:28
    Content type: Research Published on:

  27. The level (or frequency) of circulating monocyte subpopulations such as classical (CD14hiCD16-) and non-classical (CD14dimCD16+) monocytes varies during the course of HIV disease progression and antiretroviral th...

    Authors: Lillian Seu, Gabriel M Ortiz, Trevor D Burt, Steven G Deeks, Jeffrey N Martin and Joseph M McCune
    Citation: AIDS Research and Therapy 2014 11:27
    Content type: Research Published on:

  28. Lipohypertrophy does not appear to be an adverse ART reaction while lipoatrophy is clearly associated with the use of stavudine (d4T) and zidovudine (AZT). In low and middle income countries d4T has only recen...

    Authors: Zulfa Abrahams, Joel A Dave, Gary Maartens, Maia Lesosky and Naomi S Levitt
    Citation: AIDS Research and Therapy 2014 11:26
    Content type: Research Published on:

  29. Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities.

    Authors: Yassine Bouatou, Caroline Flora Samer, Kuntheavy Roseline Ing Lorenzini, Youssef Daali, Samira Daou, Marc Fathi, Michela Rebsamen, Jules Desmeules, Alexandra Calmy and Monica Escher
    Citation: AIDS Research and Therapy 2014 11:25
    Content type: Case report Published on:

  30. Despite recommendations by the Centers for Disease Control (CDC) that all adults be offered non-targeted HIV screening in all care settings, screening in acute-care settings remains unacceptably low. We perfor...

    Authors: Rachel A Bender Ignacio, Jacqueline Chu, Melinda C Power, Jeffrey Douaiher, Jordan D Lane, Jeffrey P Collins and Valerie E Stone
    Citation: AIDS Research and Therapy 2014 11:24
    Content type: Research Published on:

  31. HIV-1 entry into host cells is mediated by interactions between the virus envelope glycoprotein (gp120/gp41) and host-cell receptors. N-glycans represent approximately 50% of the molecular mass of gp120 and serve...

    Authors: Milan Raska, Lydie Czernekova, Zina Moldoveanu, Katerina Zachova, Matt C Elliott, Zdenek Novak, Stacy Hall, Michael Hoelscher, Leonard Maboko, Rhubell Brown, Phillip D Smith, Jiri Mestecky and Jan Novak
    Citation: AIDS Research and Therapy 2014 11:23
    Content type: Research Published on:

  32. The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl withi...

    Authors: Yanmei Jiao, Xin Sun, Xiaojie Huang, Wei Li, Tong Zhang and Hao Wu
    Citation: AIDS Research and Therapy 2014 11:22
    Content type: Short report Published on:

  33. HCV RNA viral load is an important predictor of sustained virological response and, recently, a significant correlation with liver fibrosis was described. We investigated on possible influence of clinical and ...

    Authors: Monica Basso, Marzia Franzetti, Renzo Scaggiante, Andrea Sattin, Carlo Mengoli, Mario Cruciani, Marta Fiscon, Giorgio Palù and Saverio Giuseppe Parisi
    Citation: AIDS Research and Therapy 2014 11:21
    Content type: Research Published on:

  34. Microsporidia have become increasingly recognized as opportunistic pathogens since the genesis of the AIDS epidemic. The incidence of microsporidiosis has decreased with the advent of combination antiretrovira...

    Authors: Maude Loignon, Louise-Geneviève Labrecque, Céline Bard, Yves Robitaille and Emil Toma
    Citation: AIDS Research and Therapy 2014 11:20
    Content type: Case report Published on:

  35. To optimize treatment regimens, we assessed human immunodeficiency virus (HIV) diversity and the prevalence of transmitted drug resistance (TDR) among men who have sex with men (MSM) in Anhui province, China.

    Authors: Yuelan Shen, Bin Su, Jianjun Wu, Yizu Qin, Lin Jin, Lifeng Miao, Aiwen Liu and Xiaoli Cheng
    Citation: AIDS Research and Therapy 2014 11:19
    Content type: Research Published on:

  36. Data on the effectiveness of second-line antiretroviral therapy (ART) in resource-limited countries of Eastern Europe is limited. Objective of this study was to evaluate virological outcomes of second-line ART...

    Authors: Nikoloz Chkhartishvili, Lali Sharvadze, Natia Dvali, Marine Karchava, Nino Rukhadze, Maia Lomtadze, Otar Chokoshvili and Tengiz Tsertsvadze
    Citation: AIDS Research and Therapy 2014 11:18
    Content type: Research Published on:

  38. Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday cl...

    Authors: Claudia Beisel, Martin Heuer, Benjamin Otto, Johannes Jochum, Stefan Schmiedel, Sandra Hertling, Olaf Degen, Stefan Lüth, Jan van Lunzen and Julian Schulze zur Wiesch
    Citation: AIDS Research and Therapy 2014 11:16
    Content type: Research Published on:

  39. In response to an article published in 2012 by officials at the US Department of Health and Human Services (DHHS), an independent analysis of state-based federal resource allocation for HIV was conducted to de...

    Authors: Willie H Oglesby, Joseph L Smith and Sonia A Alemagno
    Citation: AIDS Research and Therapy 2014 11:15
    Content type: Short report Published on:

  40. HIV-1 coreceptor tropism testing is used to evaluate eligibility for CCR5 antagonist therapy. However, HIV-1 RNA-based tests are not suitable for virologically suppressed patients, therefore the use of provira...

    Authors: Jennifer Brown, Harold Burger, Barbara Weiser, Richard B Pollard, Xiao-Dong Li, Lynell J Clancy, Russell E Baumann, Amy A Rogers, Hasnah B Hamdan, Rick L Pesano and Ron M Kagan
    Citation: AIDS Research and Therapy 2014 11:14
    Content type: Methodology Published on:

  42. The precise efficacy of nucleoside analogue reverse-transcriptase inhibitors (NRTIs) in preventing and inhibiting virus replication remains unknown in RT-SHIV infected Chinese-origin rhesus macaques (Ch RM).

    Authors: Wei Wang, Nan Yao, Zhe Cong, Hong Jiang, Chuan Qin and Qiang Wei
    Citation: AIDS Research and Therapy 2014 11:12
    Content type: Short report Published on:

  43. Long and short term side effects of antiretroviral drugs are not fully understood yet. Here a case of reversible blood count changes following post exposure prophylaxis with tenofovir/emtricitabin and lopinavi...

    Authors: Benjamin T Schleenvoigt, John P Fobiwe, Peter M Keller, Stefan Hagel and Mathias W Pletz
    Citation: AIDS Research and Therapy 2014 11:11
    Content type: Case report Published on:

  44. A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers whose efforts often go unrecognized. AIDS Research and Therapy is very grateful for the support of high...

    Authors: Kailash Gupta
    Citation: AIDS Research and Therapy 2014 11:8
    Content type: Reviewer acknowledgement Published on:

  45. Prior studies have suggested that HAART initiation may vary by race/ethnicity. Utilizing the U.S. military healthcare system, which minimizes confounding from healthcare access, we analyzed whether timing of H...

    Authors: Erica N Johnson, Mollie P Roediger, Michael L Landrum, Nancy F Crum-Cianflone, Amy C Weintrob, Anuradha Ganesan, Jason F Okulicz, Grace E Macalino and Brian K Agan
    Citation: AIDS Research and Therapy 2014 11:10
    Content type: Research Published on:

  46. An increasing number of people on antiretroviral therapy (ART) in sub-Saharan Africa has led to declines in HIV related morbidity and mortality. However, virologic failure (VF) and acquired drug resistance (AD...

    Authors: Amin S Hassan, Helen M Nabwera, Shalton M Mwaringa, Clare A Obonyo, Eduard J Sanders, Tobias F Rinke de Wit, Patricia A Cane and James A Berkley
    Citation: AIDS Research and Therapy 2014 11:9
    Content type: Research Published on:

  47. This study assesses the relationships between lymphocyte and monocyte subsets and intelligence quotient (IQ) scores in antiretroviral therapy (ART)-naive, HIV-infected Thai children without advanced HIV disease.

    Authors: Jintanat Ananworanich, Torsak Bunupuradah, Tanakorn Apornpong, Pope Kosalaraksa, Rawiwan Hansudewechakul, Suparat Kanjanavanit, Chaiwat Ngampiyaskul, Jurai Wongsawat, Wicharn Luesomboon, Nicole Ngo-Giang-Huong, Tanyathip Jaimulwong, Stephen J Kerr, Pim Brouwers, William T Shearer and Thanyawee Puthanakit
    Citation: AIDS Research and Therapy 2014 11:7
    Content type: Short report Published on:

  48. Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected ...

    Authors: Anne K Monroe, Adrian S Dobs, Frank J Palella, Lawrence A Kingsley, Mallory D Witt and Todd T Brown
    Citation: AIDS Research and Therapy 2014 11:6
    Content type: Research Published on:

  50. Central nervous system involvement in AIDS patients can present at any stage of the disease. Brain lesions detected in imaging studies are usually treated empirically. A brain biopsy is indicated in the absenc...

    Authors: Zion Zibly, Itzchak Levy, Vlady Litchevski, Dvora Nass, Chen Hofmann, Jacob Barham, Christian A Graves, Roberto Spiegelmann, Moshe Hadani and Zvi R Cohen
    Citation: AIDS Research and Therapy 2014 11:4
    Content type: Short report Published on:

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AIDS Research and Therapy

ISSN: 1742-6405

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