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  1. Human immunodeficiency virus (HIV) and extended spectrum beta lactamase (ESBL) producing Enterobacteriaceae infections are the major challenges in sub-Saharan Africa. Data on the carriage rate of ESBL producin...

    Authors: Biruk Bayleyegn, Roman Fisaha and Desie Kasew

    Citation: AIDS Research and Therapy 2021 18:19

    Content type: Research

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  2. First ambitious target by 2020 of UNAIDS is that 90% of people living with HIV know their HIV status. In people older than 18 months of age, serological confirmation test is recommended to confirm HIV infection.

    Authors: Edmond Tchiakpe, René K. Keke, Nicole Vidal, Moussa Bachabi, Flore Armande Gangbo, Halimatou Diop‑Ndiaye, Coumba Toure‑Kane and Akadiri Yessoufou

    Citation: AIDS Research and Therapy 2021 18:18

    Content type: Case Report

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  3. Failure on second-line antiretroviral therapy (ART) with protease inhibitor (PI) mutations (VF-M) is on the rise. However, there is a paucity of information on the factors associated with this observation in l...

    Authors: Hellen Musana, Jude Thaddeus Ssensamba, Mary Nakafeero, Henry Mugerwa, Flavia Matovu Kiweewa, David Serwadda and Francis Ssali

    Citation: AIDS Research and Therapy 2021 18:17

    Content type: Research

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  4. Progress toward the global target for 95% virological suppression among those on antiretroviral treatment (ART) is still suboptimal. We describe the viral load (VL) cascade, the incidence of virological failur...

    Authors: Anita Mesic, Alexander Spina, Htay Thet Mar, Phone Thit, Tom Decroo, Annick Lenglet, Moe Pyae Thandar, Thin Thin Thwe, Aung Aung Kyaw, Tobias Homan, Mitchell Sangma, Ronald Kremer, Jane Grieg, Erwan Piriou, Koert Ritmeijer, Josefien Van Olmen…

    Citation: AIDS Research and Therapy 2021 18:16

    Content type: Research

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  5. Antiretroviral therapy (ART) adherence is a primary determinant of sustained viral suppression, HIV transmission risk, disease progression and death. The World Health Organization recommends that adherence sup...

    Authors: Rita Nakalega, Nelson Mukiza, Henry Debem, George Kiwanuka, Ronald Makanga Kakumba, Robert Menge, Irene-Kinera Kagimu, Catherine Nakaye, Juliet Allen Babirye, Hellen Kaganzi, Zubair Lukyamuzi, Samuel Kizito, Cynthia Ndikuno Kuteesa and Andrew Mujugira

    Citation: AIDS Research and Therapy 2021 18:15

    Content type: Research

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  6. HIV testing and early linkage to care are critical for reducing the risk of HIV transmission. HIV self-testing (HIVST) is a useful tool for increasing HIV testing frequency.This study aimed to investigate HIVS...

    Authors: Hang Hong, Hong-bo Shi, Hai-bo Jiang, Hong-jun Dong and Yun-liang Shen

    Citation: AIDS Research and Therapy 2021 18:14

    Content type: Research

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  7. The prevalence of disclosure of status to children living with the Human Immunodeficiency Virus (HIV) is low in most sub-Saharan African countries, leading to poor compliance and adverse psychological outcomes...

    Authors: Margaret Amankwah-Poku, Delight Abla Klutsey and Kwaku Oppong Asante

    Citation: AIDS Research and Therapy 2021 18:13

    Content type: Research

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  8. The frequency of new-onset HIV-associated seizure in the HIV-infected patient is estimated to be between 2 and 11%. Identifying the underlying etiology of new-onset seizure will have a vital impact on the mort...

    Authors: Biniyam A. Ayele, Zemichael Getu and Amen Samuel

    Citation: AIDS Research and Therapy 2021 18:12

    Content type: Case Report

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  9. The widely-expressed molecule CD38 is a single-stranded type II transmembrane glycoprotein that is mainly involved in regulating the differentiation and activation state of the cell. CD38 has broad and complex...

    Authors: Liqi Lu, Jie Wang, Qian Yang, Xiuqiao Xie and Yuanshuai Huang

    Citation: AIDS Research and Therapy 2021 18:11

    Content type: Review

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  10. In 2013, the World Health Organisation (WHO) recommended Option B+ as a strategy to prevent mother-to-child transmission (PMTCT) of HIV. In option B+ , lifelong antiretroviral therapy (ART) is offered to all H...

    Authors: Anesu N. Chimwaza, Hannock Tweya, Owen Mugurungi, Angela Mushavi, Solomon Mukungunugwa, Ngwarai Sithole, Justice Nyakura, Mbazi Senkoro, Philip Owiti, Ronald Ncube, Talent Tapera, Winnie Mandewo, Jeffrey K. Edwards, Aveneni Mangombe and Isaac Taramusi

    Citation: AIDS Research and Therapy 2021 18:10

    Content type: Review

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  11. HIV status disclosure facilitates access to HIV-related prevention and treatment services and increases opportunities for social support, HIV risk reduction with partners, and index testing for sexual partners...

    Authors: Amon Exavery, John Charles, Asheri Barankena, Erica Kuhlik, Godfrey Martin Mubyazi, Christina Kyaruzi, Tumainiel Mbwambo, Amal Ally, Remmy Mseya, Levina Kikoyo and Elizabeth Jere

    Citation: AIDS Research and Therapy 2021 18:9

    Content type: Research

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  12. Peer education and HIV risk perception are related to HIV testing uptake among key populations. We aimed to examine the association between peer education, HIV risk perception, and HIV testing uptake, as well ...

    Authors: Yuxi Lin, Chuanxi Li, Lin Wang, Kedi Jiao and Wei Ma

    Citation: AIDS Research and Therapy 2021 18:8

    Content type: Research

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  13. Good adherence to antiretroviral therapy (ART) and retention in care are essential for the effectiveness of an HIV care program. With the current increase in numbers of people living with HIV taking second-lin...

    Authors: Edwin Nuwagira, Boniface A. E. Lumori, Rose Muhindo, Michael Kanyesigye, Abdallah Amir, Winnie Muyindike and Conrad Muzoora

    Citation: AIDS Research and Therapy 2021 18:7

    Content type: Research

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  15. Human immunodeficiency virus attacked an immune cell and the CD4 cell which is responsible for the body’s immune to infectious agents. Acquired immunodeficiency syndrome is one of the major public health probl...

    Authors: Kindu Kebede

    Citation: AIDS Research and Therapy 2021 18:5

    Content type: Research

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  16. There is limited evidence on the modification or stopping of antiretroviral therapy (ART) regimens, including novel antiretroviral drugs. The aim of this study was to evaluate the discontinuation of first ART ...

    Authors: Volkan Korten, Deniz Gökengin, Gülhan Eren, Taner Yıldırmak, Serap Gencer, Haluk Eraksoy, Dilara Inan, Figen Kaptan, Başak Dokuzoğuz, Ilkay Karaoğlan, Ayşe Willke, Mehmet Gönen and Önder Ergönül

    Citation: AIDS Research and Therapy 2021 18:4

    Content type: Research

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  17. Pediatric tuberculosis (TB), human immunodeficiency virus (HIV), and TB-HIV co-infection are health problems with evidence-based diagnostic and treatment algorithms that can reduce morbidity and mortality. Imp...

    Authors: W. Chris Buck, Hanh Nguyen, Mariana Siapka, Lopa Basu, Jessica Greenberg Cowan, Maria Inês De Deus, Megan Gleason, Ferreira Ferreira, Carla Xavier, Benedita Jose, Criménia Muthemba, Beatriz Simione and Peter Kerndt

    Citation: AIDS Research and Therapy 2021 18:3

    Content type: Research

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  18. Pre-exposure prophylaxis (PrEP) for HIV is instrumental in the prevention of HIV for HIV-uninfected persons, by drastically reducing the risk of acquisition in the case of high-risk exposures. Despite its demo...

    Authors: Marie Bistoquet, Alain Makinson, Vincent Tribout, Cyril Perrollaz, Gérard Bourrel, Jacques Reynes and Agnès Oude Engberink

    Citation: AIDS Research and Therapy 2021 18:2

    Content type: Research

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  19. South Africa, with one of the highest HIV prevalences in the world, introduced the universal test and treat (UTT) programme in September 2016. Barriers to sustained viral suppression may include drug resistanc...

    Authors: Pascal O. Bessong, Nontokozo D. Matume and Denis M. Tebit

    Citation: AIDS Research and Therapy 2021 18:1

    Content type: Review

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  20. Diagnosis of people living with HIV (PLHIV) is the first step toward achieving the new Fast Track Strategy to end AIDS by 2030: 95-95-95. However, reaching PLHIV is especially difficult in resource-limited set...

    Authors: Mohammad Pour, Linda James, Kamlendra Singh, Samuel Mampunza, Franklin Baer, JoAnna Scott, Michael G. Berg, Mary A. Rodgers, Gavin A. Cloherty, John Hackett Jr and Carole P. McArthur

    Citation: AIDS Research and Therapy 2020 17:67

    Content type: Research

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  21. With increased use of antiretroviral therapy (ART), HIV mortality rates are declining and people living with HIV (PLWH) are surviving longer. We characterized CD4 recovery and viral suppression among adults ag...

    Authors: Emmanuel Bahemana, Allahna Esber, Nicole Dear, Kavitha Ganesan, Ajay Parikh, Domonique Reed, Lucas Maganga, Samoel Khamadi, Mucho Mizinduko, Anange Lwilla, Dorothy Mkondoo, Gwamaka Mwaisanga, Nancy Somi, John Owouth, Jonah Maswai, Francis Kiweewa…

    Citation: AIDS Research and Therapy 2020 17:66

    Content type: Research

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  22. Analytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving antiretroviral therapy (ART)-free HIV remission. Understanding the accepta...

    Authors: Jillian S. Y. Lau, Miranda Z. Smith, Brent Allan, Cipriano Martinez, Jennifer Power, Sharon R. Lewin and James H. McMahon

    Citation: AIDS Research and Therapy 2020 17:65

    Content type: Short Report

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  23. A substantial number of persons living with HIV (PLWH) in Nigeria do not experience durable viral suppression on first-line antiretroviral therapy (ART). Understanding risk factors for first-line treatment fai...

    Authors: Nicaise Ndembi, Fati Murtala-Ibrahim, Monday Tola, Jibreel Jumare, Ahmad Aliyu, Peter Alabi, Charles Mensah, Alash’le Abimiku, Miguel E. Quiñones-Mateu, Trevor A. Crowell, Soo-Yon Rhee, Robert W. Shafer, Ravindra Gupta, William Blattner, Manhattan E. Charurat and Patrick Dakum

    Citation: AIDS Research and Therapy 2020 17:64

    Content type: Research

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  24. Tuberculosis (Tb) is the most frequent opportunistic infection among people living with HIV infection. The impact of Tb co-infection in the establishment and maintenance of the HIV reservoir is unclear.

    Authors: Jingna Xun, Tangkai Qi, Lei Zou, Qi Tang, Yinzhong Shen, Junyang Yang, Luman Xie, Yongjia Ji, Renfang Zhang, Li Liu, Jiangrong Wang, Corky Steinhart, Zhenyan Wang, Yang Tang, Wei Song, Jianjun Sun…

    Citation: AIDS Research and Therapy 2020 17:63

    Content type: Research

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  25. Improved point-of-care diagnostic tests for tuberculosis (TB) in severe immune suppressed people living with HIV (PLWH) are needed to decrease morbidity and mortality outcomes. The aim of the study is to evalu...

    Authors: Juan Ignacio García, Johanna Meléndez, Rosa Álvarez, Carlos Mejía-Chew, Holden V. Kelley, Sabeen Sidiki, Alejandra Castillo, Claudia Mazariegos, Cesar López-Téllez, Diana Forno, Nancy Ayala, Joan-Miquel Balada-Llasat, Carlos Rodolfo Mejía-Villatoro, Shu-Hua Wang, Jordi B. Torrelles and Janet Ikeda

    Citation: AIDS Research and Therapy 2020 17:62

    Content type: Research

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  26. Although HIV-related deaths have decreased dramatically following the introduction of antiretroviral therapy (ART), HIV infection itself causes increased morbidity and mortality for both non-AIDS-related event...

    Authors: Martina Maritati, Trentini Alessandro, Nunzia Zanotta, Manola Comar, Tiziana Bellini, Laura Sighinolfi and Carlo Contini

    Citation: AIDS Research and Therapy 2020 17:61

    Content type: Research

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  27. Rapid antiretroviral therapy (ART), ideally initiated within twenty-four hours of diagnosis, may be crucial in efforts to increase virologic suppression and reduce HIV transmission. Recent studies, including d...

    Authors: Courtney E. Sims Gomillia, Kandis V. Backus, James B. Brock, Sandra C. Melvin, Jason J. Parham and Leandro A. Mena

    Citation: AIDS Research and Therapy 2020 17:60

    Content type: Research

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  28. During the COVID-19 pandemic, hospitals faced increasing pressure, where people living with HIV risked to either acquire SARS-CoV-2 and to interrupt the HIV continuum of care.

    Authors: Eugenia Quiros-Roldan, Paola Magro, Canio Carriero, Annacarla Chiesa, Issa El Hamad, Elena Tratta, Raffaella Fazio, Beatrice Formenti and Francesco Castelli

    Citation: AIDS Research and Therapy 2020 17:59

    Content type: Research

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  29. AIDS-related KS generally involves cutaneous lesions, that slowly progress over months to years. Neither rapidly progressing of KS nor KS complicated with hemophagocytic syndrome (HPS) has rarely been reported.

    Authors: Pingzheng Mo, Liping Deng, Xiaoping Chen, Yong Xiong and Yongxi Zhang

    Citation: AIDS Research and Therapy 2020 17:58

    Content type: Case Report

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  30. Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died...

    Authors: Kennedy Michael Ngowi, Lydia Masika, Furaha Lyamuya, Eva Muro, Blandina T. Mmbaga, Mirjam A. G. Sprangers, Pythia T. Nieuwkerk, Rob E. Aarnoutse, Peter Reiss and I. Marion Sumari-de Boer

    Citation: AIDS Research and Therapy 2020 17:57

    Content type: Case Report

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  31. HIV Self-Testing (HIVST) is universally accepted as an innovative strategy complimenting existing HIV testing services to archive the UNAIDS, 95-95-95 goals by 2030. However, the adoption of HIVST is lagging i...

    Authors: Proches Arobogast Vara, Luyeye Sostenes Buhulula, Fatma Aziz Mohammed and Bernard Njau

    Citation: AIDS Research and Therapy 2020 17:56

    Content type: Research

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  32. Adolescent girls and young women (AGYW) remain disproportionately affected by HIV. In a rural area of South Africa with an annual incidence (2011–2015) of 5 and 7% per annum for 15–19 and 20–24-year olds respe...

    Authors: Sarah E Nakasone, Natsayi Chimbindi, Nondumiso Mthiyane, Busisiwe Nkosi, Thembelihle Zuma, Kathy Baisley, Jaco Dreyer, Deenan Pillay, Sian Floyd, Isolde Birdthistle, Janet Seeley and Maryam Shahmanesh

    Citation: AIDS Research and Therapy 2020 17:55

    Content type: Research

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  33. Cytomegalovirus (CMV) is among the most common opportunistic infections identified in patients with HIV/AIDS. CMV often targets the colon in such patients. However, the role of regulatory T cells (Tregs) and Prog...

    Authors: Lei Sun, Kun Yang, Liang Zhang, Li-ming Qi, Jia-min Chen, Ping Li, Jiang Xiao, Hong-xin Zhao and Peng Wang

    Citation: AIDS Research and Therapy 2020 17:54

    Content type: Research

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  34. In the context of scaling the viral load in resource limited settings, following HIV infected patient’s adults and children with CD4+ T-lymphocyte count still very important in settings where the decentralizat...

    Authors: Bertrand Sagnia, Fabrice Mbakop Ghomsi, Ana Gutierrez, Samuel Sosso, Rachel Kamgaing, Aubin Joseph Nanfack, Nadesh Nji, Georgia Ambada, Abel Lissom, Thibaut Flaurant Tchouangueu, Loveline Ngu Ndengkoh, Irenée Domkam, Godwin Nchinda and Alexis Ndjolo

    Citation: AIDS Research and Therapy 2020 17:53

    Content type: Research

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  35. Hemophagocytic lymphohistiocytosis syndrome (HLS) is an immune-mediated life-threatening disease considered as a medical emergency, with a potentially fatal multisystem inflammatory outcome. We present a patie...

    Authors: Luz A. González-Hernández, Monserrat Alvarez-Zavala, Rodolfo I. Cabrera-Silva, Pedro Martínez-Ayala, Fernando Amador-Lara, Aída S. Ramírez-González, Ana L. Ron-Magaña, Vida V. Ruiz Herrera, Karina Sánchez-Reyes and Jaime F. Andrade-Villanueva

    Citation: AIDS Research and Therapy 2020 17:52

    Content type: Case Report

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  36. The key cause of HIV transmission is failure to provide adequate information about HIV/AIDS which is a substantial public health issue in low and middle-income countries. While global health coverage continues...

    Authors: Chilot Desta Agegnehu, Bisrat Misganaw Geremew, Malede Mequanent Sisay, Kindie Fentahun Muchie, Zinash Teferu Engida, Temesgen Worku Gudayu, Daniel Sisay Weldetsadik and Alemneh Mekuriaw Liyew

    Citation: AIDS Research and Therapy 2020 17:51

    Content type: Research

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  37. Real-time, objective measures of adherence to antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are needed to better assess adherence levels and to expedite clinical response for those with subo...

    Authors: Ashley R. Bardon, Jane M. Simoni, Leif M. Layman, Joanne D. Stekler and Paul K. Drain

    Citation: AIDS Research and Therapy 2020 17:50

    Content type: Research

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  38. In resource poor countries like Ethiopia, little is known about the survival of patients treated with antiretroviral therapy which depends on different factors. Evidence shows that mortality has been high part...

    Authors: Abewa Kebede, Fasil Tessema, Gadisa Bekele, Zerihun Kura and Hailu Merga

    Citation: AIDS Research and Therapy 2020 17:49

    Content type: Research

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  39. In Sub-Saharan Africa where HIV disproportionately affects women, heterosexual male sex workers (HMSW) and their female clients are at risk of acquiring or transmitting HIV and other STIs. However, few studies...

    Authors: Richard Muhindo, Andrew Mujugira, Barbara Castelnuovo, Nelson K. Sewankambo, Rosalind Parkes-Ratanshi, Juliet Kiguli, Nazarius Mbona Tumwesigye and Edith Nakku-Joloba

    Citation: AIDS Research and Therapy 2020 17:48

    Content type: Research

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  40. It is well known that people living with HIV (PLWH) is in higher risk for the development of depression and it has also been suggested that the use of efavirenz into the antiretroviral regimens increases even ...

    Authors: Alejandro Checa, Alberto Castillo, Malena Camacho, William Tapia, Isabel Hernandez and Enrique Teran

    Citation: AIDS Research and Therapy 2020 17:47

    Content type: Short Report

    Published on:

  41. The COVID-19 has been a severe pandemic all around the world. Nowadays the patient with co-infection of HIV and SARS-CoV-2 was rarely reported. Here we reported a special case with HIV and SARS-CoV-2 co-infect...

    Authors: Wu Menghua, Zheng Xin, Liu Jianwei, Zhang Yu and Yao Qinwei

    Citation: AIDS Research and Therapy 2020 17:46

    Content type: Case Report

    Published on:

  42. The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced pa...

    Authors: Inés Suárez-García, Cristina Moreno, Marta Ruiz-Algueró, María Jesús Pérez-Elías, Marta Navarro, Marcos Díez Martínez, Pompeyo Viciana, Laura Pérez-Martínez, Miguel Górgolas, Concha Amador, Miguel Alberto de Zárraga and Inma Jarrín

    Citation: AIDS Research and Therapy 2020 17:45

    Content type: Research

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  43. To evaluate the impact of AIDS-defining events (ADE) on long-term mortality of HIV positive individuals on antiretroviral therapy (ART), a retrospective HIV/AIDS treatment cohort study performed in Southwester...

    Authors: Yunxuan Huang, Oulu Zhou, Zhigang Zheng, Yuexiang Xu, Yi Shao, Chunwei Qin, Fengxiang Qin, Jingzhen Lai, Huifang Liu, Rongfeng Chen, Li Ye, Hao Liang, Xionglin Qin and Junjun Jiang

    Citation: AIDS Research and Therapy 2020 17:44

    Content type: Research

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  44. Early detection of viremia in HIV infected patients on anti-retroviral therapy (ART) is important to prevent disease progression as well as accumulation of drug resistance mutations. This makes HIV viral load ...

    Authors: Ashwini Shete, Sampada Dhayarkar, Ashwini Dhamanage, Smita Kulkarni, Manisha Ghate, Shashikala Sangle, Uttam Medhe, Vinita Verma, Shobini Rajan, Toshio Hattori and Raman Gangakhedkar

    Citation: AIDS Research and Therapy 2020 17:43

    Content type: Research

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  45. HIV status disclosure facilitates receipt of HIV prevention and treatment services. Although disclosure to sexual partners, family members or friends has been extensively studied, disclosure to community-based...

    Authors: John Charles, Amon Exavery, Asheri Barankena, Erica Kuhlik, Godfrey M. Mubyazi, Ramadhani Abdul, Alison Koler, Levina Kikoyo and Elizabeth Jere

    Citation: AIDS Research and Therapy 2020 17:42

    Content type: Research

    Published on:

  46. In pregnancy, reduction of HIV plasma viral load (pVL) for the prevention of vertical transmission is time-constrained. The study primary objective is to investigate factors associated with faster initial HIV ...

    Authors: Jasmini Alagaratnam, Helen Peters, Kate Francis, Natasha Kay, Yvonne Gilleece, Fionnuala P. Finnerty, Rosanna E. Grimes, Sarah Parry, Mags Portman, Brenton C. Wait, Rimi Shah, Sherie Roedling, David A. Hawkins, Sarah Chitty, Liat Sarner, Rebecca Marcus…

    Citation: AIDS Research and Therapy 2020 17:41

    Content type: Research

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  47. The US President’s Emergency Plan for AIDS Relief (PEPFAR) was launched to increase access to antiretroviral treatment (ART) among people living with HIV (PLHIV) and to prevent new HIV infections globally. As ...

    Authors: Andrew T. Boyd, Ikwo Oboho, Heather Paulin, Hammad Ali, Catherine Godfrey, Anand Date and J. Sean Cavanaugh

    Citation: AIDS Research and Therapy 2020 17:40

    Content type: Review

    Published on:

  48. Antiretroviral treatment has played a pivotal role in the reduction of HIV/AIDS-related morbidity and mortality. However, treatment options can be impaired by the development of antiretroviral treatment failur...

    Authors: Jemberu Nega, Solomon Taye, Yihenew Million, Chaturaka Rodrigo and Setegn Eshetie

    Citation: AIDS Research and Therapy 2020 17:39

    Content type: Research

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  49. Vacuolar encephalomyelopathy, a disregarded diagnosis lately, was a major neurological disease in the terminal stages of human immunodeficiency virus (HIV)-1 infection in the pre-antiretroviral therapy (ART) e...

    Authors: Kazumasa Akagi, Kazuko Yamamoto, Asuka Umemura, Shotaro Ide, Tatsuro Hirayama, Takahiro Takazono, Yoshifumi Imamura, Taiga Miyazaki, Noriho Sakamoto, Hirokazu Shiraishi, Hideaki Takahata, Yoshiaki Zaizen, Junya Fukuoka, Minoru Morikawa, Kazuto Ashizawa, Katsuji Teruya…

    Citation: AIDS Research and Therapy 2020 17:38

    Content type: Case Report

    Published on:

  50. The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individ...

    Authors: Vijay Harypursat, Yihong Zhou, Shengquan Tang and Yaokai Chen

    Citation: AIDS Research and Therapy 2020 17:37

    Content type: Review

    Published on:

  • ISSN: 1742-6405 (electronic)

AIDS Research and Therapy

ISSN: 1742-6405

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