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  1. Once-daily, single-tablet regimens (STRs) have been associated with improved patient outcomes compared to multi-tablet regimens (MTRs). This study evaluated real world adherence and persistence of HIV antiretr...

    Authors: Joshua Cohen, Anne Beaubrun, Richa Bashyal, Ahong Huang, Jieni Li and Onur Baser

    Citation: AIDS Research and Therapy 2020 17:12

    Content type: Research

    Published on:

  3. The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in th...

    Authors: Jing Ouyang, Stéphane Isnard, John Lin, Brandon Fombuena, André Marette, Bertrand Routy, Yaokai Chen and Jean-Pierre Routy

    Citation: AIDS Research and Therapy 2020 17:10

    Content type: Review

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  4. The aim of this study was to assess trends in drug resistance and associated clinical and programmatic factors at a national level during the rapid scale up of ART.

    Authors: Pengtao Liu, Hui Xing, Lingjie Liao, Yi Feng, Xuebing Leng, Jing Wang, Wei Kan, Jing Yan, Yang Li, Zhongbao Zuo, Yinghui You, Yuhua Ruan and Yiming Shao

    Citation: AIDS Research and Therapy 2020 17:9

    Content type: Research

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  5. Antiretroviral adherence is essential to HIV treatment efficacy. Various self-reported measures are commonly used for assessing antiretroviral adherence. Limited data are available regarding the validity of th...

    Authors: Quan Zhang, Xiaoming Li, Shan Qiao, Zhiyong Shen and Yuejiao Zhou

    Citation: AIDS Research and Therapy 2020 17:8

    Content type: Research

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  6. Expanded access to combination antiretroviral therapy (cART) throughout sub-Saharan Africa over the last decade has remarkably improved the prognosis of persons living with HIV (PLWH). However, some PLWH exper...

    Authors: Ernest Ekong, Nicaise Ndembi, Prosper Okonkwo, Patrick Dakum, John Idoko, Bolanle Banigbe, James Okuma, Patricia Agaba, William Blattner, Clement Adebamowo and Manhattan Charurat

    Citation: AIDS Research and Therapy 2020 17:7

    Content type: Research

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  7. In resource-limited settings, multi-experienced HIV infected patients are often prescribed raltegravir for salvage therapy. Patients failing raltegravir-containing regimens require other drugs including other ...

    Authors: Aurelio Orta-Resendiz, Roberto A. Rodriguez-Diaz, Luis A. Angulo-Medina, Mario Hernandez-Flores and Luis E. Soto-Ramirez

    Citation: AIDS Research and Therapy 2020 17:6

    Content type: Research

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  8. Entry inhibitors, such as Maraviroc, hold promise as components of HIV treatment and/or pre-exposure prophylaxis in Africa. Maraviroc inhibits the interaction between HIV Envelope gp120 V3-loop and CCR5 corece...

    Authors: Nontokozo D. Matume, Denis M. Tebit and Pascal O. Bessong

    Citation: AIDS Research and Therapy 2020 17:5

    Content type: Review

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  9. For migrant female sex workers (FSWs) at the Sino-Vietnamese border, the impact of work time in their current location on the spread of HIV/AIDS is not clear.

    Authors: Yu Zhang, Bingyu Liang, Deping Liu, Guangwu Wei, Shide Mo, Aidan Nong, Chuanyi Ning, Yanyan Liao, Junjun Jiang, PeiJiang Pan, Yuan Yang, Ning Zang, Dinh Vanphu, Nguyen Van, Li Ye, Hao Liang…

    Citation: AIDS Research and Therapy 2020 17:4

    Content type: Research

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  10. Despite advances in the treatment quality of HIV throughout the world, several countries are still facing numerous obstacles in delivering HIV treatment at a sufficiently high quality, putting patients’ lives ...

    Authors: S. Jespersen, F. Månsson, J. Lindman, C. Wejse, C. Medina, Z. J. da Silva, DdS Te, P. Medstrand, J. Esbjörnsson and B. L. Hønge

    Citation: AIDS Research and Therapy 2020 17:3

    Content type: Review

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  11. Resistance to antiretroviral drugs is a major challenge among Human Immunodeficiency Virus (HIV) positive patients receiving antiretroviral therapy (ART). Mutations that arise as a result of this are diverse a...

    Authors: Alisen Ayitewala, Fred Kyeyune, Pamela Ainembabazi, Eva Nabulime, Charles Drago Kato and Immaculate Nankya

    Citation: AIDS Research and Therapy 2020 17:2

    Content type: Research

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  12. Dolutegravir (DTG)-based antiretroviral therapy (ART) is currently the first-line treatment for people living with HIV. Neuropsychiatric adverse events (NP-AEs) have been reported with DTG but neuropsychiatric...

    Authors: Phillip Chan, Orlanda Goh, Eugène Kroon, Donn Colby, Carlo Sacdalan, Suteeraporn Pinyakorn, Peeriya Prueksakaew, Peter Reiss, Jintanat Ananworanich, Victor Valcour, Serena Spudich and Robert Paul

    Citation: AIDS Research and Therapy 2020 17:1

    Content type: Research

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  13. Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prod...

    Authors: Dane Turner, Douglas Drak, Catherine C. O’Connor, David J. Templeton and David M. Gracey

    Citation: AIDS Research and Therapy 2019 16:40

    Content type: Research

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  14. Several studies demonstrate a correlation between sub-therapeutic concentrations of antiretroviral drugs and virologic failure. We examined the sensitivity, specificity and predictive values of sub-therapeutic...

    Authors: Allan Buzibye, Joseph Musaazi, Amrei von Braun, Sarah Nanzigu, Christine Sekaggya-Wiltshire, Andrew Kambugu, Jan Fehr, Mohammed Lamorde, Ursula Gutteck, Daniel Muller, Stefanie Sowinski, Steven J. Reynolds and Barbara Castelnuovo

    Citation: AIDS Research and Therapy 2019 16:39

    Content type: Research

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  15. Prior HIV testing and awareness of HIV-positive status were assessed among HIV-positive adults at 20 clinics in Eswatini. Of 2196 HIV-positive adults, 1183 (53.8%) reported no prior HIV testing, and 1948 (88.7...

    Authors: Harriet Nuwagaba-Biribonwoha, Yingfeng Wu, Averie Baird Gachuhi, Margaret L. McNairy, Veli Madau, Mathew Lamb, Sikhathele Mazibuko, Zandile Mnisi, Sean Burke, Neena Philip, Ruben Sahabo and Wafaa M. El Sadr

    Citation: AIDS Research and Therapy 2019 16:38

    Content type: Short Report

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  16. Kidney transplantation is now a viable alternative to dialysis in HIV-positive patients who achieve good immunovirological control with the currently available antiretroviral therapy regimens. This systematic ...

    Authors: Xin Zheng, Lian Gong, Wenrui Xue, Song Zeng, Yue Xu, Yu Zhang and Xiaopeng Hu

    Citation: AIDS Research and Therapy 2019 16:37

    Content type: Research

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  17. After the launching of the « Test & Treat » strategy and the wider accessibility to viral load (VL), evaluating virological success (VS) would help in meeting the UNAIDS targets by 2020 in Cameroon.

    Authors: Joseph Fokam, Samuel Martin Sosso, Bouba Yagai, Serge Clotaire Billong, Rina Estelle Djubgang Mbadie, Rachel Kamgaing Simo, Serge Valery Edimo, Alex Durand Nka, Aline Tiga Ayissi, Junie Flore Yimga, Désiré Takou, Sylvie Moudourou, Marinette Ngo Nemb, Jean-Bosco Nfetam Elat, Maria-Mercedes Santoro, Carlo-Federico Perno…

    Citation: AIDS Research and Therapy 2019 16:36

    Content type: Research

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  18. Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this re...

    Authors: Aidana Amangaldiyeva, Salima Davlidova, Bauyrzhan Baiserkin, Natalya Dzissyuk, Jack DeHovitz and Syed Ali

    Citation: AIDS Research and Therapy 2019 16:35

    Content type: Review

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  19. To evaluate clinical outcomes after either immediate or deferred initiation of antiretroviral therapy in HIV-1-infected patients, presenting late with pneumocystis pneumonia (PCP) or toxoplasma encephalitis (TE).

    Authors: Guido Schäfer, Christian Hoffmann, Keikawus Arasteh, Dirk Schürmann, Christoph Stephan, Björn Jensen, Matthias Stoll, Johannes R. Bogner, Gerd Faetkenheuer, Jürgen Rockstroh, Hartwig Klinker, Georg Härter, Albrecht Stöhr, Olaf Degen, Eric Freiwald, Anja Hüfner…

    Citation: AIDS Research and Therapy 2019 16:34

    Content type: Research

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  20. We previously reported that four doses or four double doses of hepatitis B vaccination regimens could not significantly increase a response rate compared with standard doses. However, the antibody levels were ...

    Authors: Romanee Chaiwarith, Jutarat Praparattanapan, Wilai Kotarathititum, Jiraprapa Wipasa, Kanokporn Chaiklang and Khuanchai Supparatpinyo

    Citation: AIDS Research and Therapy 2019 16:33

    Content type: Short Report

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  21. Suboptimal adherence to HIV antiretroviral therapy (ART) and concomitant lack of viral control can have severe consequences for health and onward transmission among persons living with HIV. Little is known abo...

    Authors: James M. McMahon, Amy Braksmajer, Chen Zhang, Natalie Leblanc, Michael Chen, Angela Aidala and Janie Simmons

    Citation: AIDS Research and Therapy 2019 16:32

    Content type: Research

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  23. Expanded access to antiretroviral therapy (ART) leads to improved HIV/AIDS treatment outcomes in Nigeria, however, increasing rates of loss to follow-up among those on ART is threatening optimal standard achie...

    Authors: Ahmad Aliyu, Babatunde Adelekan, Nifarta Andrew, Eunice Ekong, Stephen Dapiap, Fati Murtala-Ibrahim, Iboro Nta, Nicaise Ndembi, Charles Mensah and Patrick Dakum

    Citation: AIDS Research and Therapy 2019 16:30

    Content type: Research

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  24. As antiretroviral therapy (ART) programs expand access, there is an increase in burden to a healthcare system. These results are reduced provider-patient contact time and poor programmatic and patient outcomes...

    Authors: Ahmad Aliyu, Samer El-Kamary, Jessica Brown, Bruce Agins, Nicaise Ndembi, Gambo Aliyu, Jibreel Jumare, Babatunde Adelekan, Patrick Dakum, Alash’le Abimiku and Manhattan Charurat

    Citation: AIDS Research and Therapy 2019 16:29

    Content type: Review

    Published on:

  25. Limited data are available regarding correlates of regular sexually transmitted infections (STIs) and HIV screening among female sex workers (FSW) in Sub-Saharan Africa. In this study, we aimed to assess the f...

    Authors: Richard Muhindo, Barbara Castelnuovo, Andrew Mujugira, Rosalind Parkes-Ratanshi, Nelson K. Sewankambo, Juliet Kiguli, Nazarius Mbona Tumwesigye and Edith Nakku-Joloba

    Citation: AIDS Research and Therapy 2019 16:28

    Content type: Research

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  26. A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming...

    Authors: Patrick Dakum, Monday Tola, Nta Iboro, Chukwuemeka A. Okolo, Olachi Anuforom, Christopher Chime, Sam Peters, Jibreel Jumare, Obinna Ogbanufe, Aliyu Ahmad and Nicaise Ndembi

    Citation: AIDS Research and Therapy 2019 16:27

    Content type: Research

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  27. According to the user instructions from the manufacturer of OraQuick HIV self-test (HIVST) kits, individuals whose kits show one red band should be considered to be HIV-negative, no matter how weak the band is...

    Authors: Rose Kisa, Joseph K. B. Matovu, Esther Buregyeya, William Musoke, Caroline J. Vrana-Diaz, Jeffrey E. Korte and Rhoda K. Wanyenze

    Citation: AIDS Research and Therapy 2019 16:26

    Content type: Short Report

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  28. Thailand has the highest prevalence of HIV among countries in Asia but has also been a pioneer in HIV prevention and treatment efforts in the region, reducing the incidence of new infections significantly over...

    Authors: Camilla Muccini, Trevor A. Crowell, Eugène Kroon, Carlo Sacdalan, Reshmie Ramautarsing, Pich Seekaew, Praphan Phanuphak, Jintanat Ananworanich, Donn J. Colby and Nittaya Phanuphak

    Citation: AIDS Research and Therapy 2019 16:25

    Content type: Review

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  29. Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years since the discovery of AIDS, ...

    Authors: Joakim Esbjörnsson, Marianne Jansson, Sanne Jespersen, Fredrik Månsson, Bo L. Hønge, Jacob Lindman, Candida Medina, Zacarias J. da Silva, Hans Norrgren, Patrik Medstrand, Sarah L. Rowland-Jones and Christian Wejse

    Citation: AIDS Research and Therapy 2019 16:24

    Content type: Review

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  30. Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is a once-daily, single-tablet regimen for treatment of HIV-1 infection. The efficacy/safety of switching to D/C/F/TAF ver...

    Authors: Gregory D. Huhn, Joseph J. Eron, Pierre-Marie Girard, Chloe Orkin, Jean-Michel Molina, Edwin DeJesus, Romana Petrovic, Donghan Luo, Erika Van Landuyt, Erkki Lathouwers, Richard E. Nettles, Kimberley Brown and Eric Y. Wong

    Citation: AIDS Research and Therapy 2019 16:23

    Content type: Research

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  31. There are approximately 72,000 people living with HIV/AIDS (PLHIV) in Peru. Non-adherence to antiretroviral therapy (ART) is the most important factor for therapeutic failure and the development of resistance....

    Authors: Juan M. Leyva-Moral, Blanca K. Loayza-Enriquez, Patrick A. Palmieri, Genesis M. Guevara-Vasquez, Ursula E. Elias-Bravo, Joan E. Edwards, María Feijoo-Cid, Lucy Y. Davila-Olano, Juan R. Rodriguez-Llanos and Franco E. Leon-Jimenez

    Citation: AIDS Research and Therapy 2019 16:22

    Content type: Research

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  32. Study aim was to evaluate the safety and durability of darunavir/cobicistat (DRV/c) in a real life setting.

    Authors: Lucia Taramasso, Elena Ricci, Antonio Cascio, Laura Valsecchi, Barbara Menzaghi, Nicola Squillace, Paolo Maggi, Giuseppe Vittorio De Socio, Chiara Dentone, Giordano Madeddu, Giovanni F. Pellicanò, Leonardo Calza, Goffredo Angioni, Paolo Bonfanti and Antonio Di Biagio

    Citation: AIDS Research and Therapy 2019 16:21

    Content type: Research

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  33. The South African public health system plays an important role in the delivery of HIV testing and treatment services. The health system is also an important conduit for targeted behaviour change communication ...

    Authors: Gavin George, Sean Beckett, Cherie Cawood, David Khanyile, Kaymarlin Govender and Ayesha B. M. Kharsany

    Citation: AIDS Research and Therapy 2019 16:20

    Content type: Research

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  34. Brazil is a low-and-middle income country (LMIC) that, despite having a large population and continental dimensions, has been able to successfully fight HIV/AIDS through a number of governmental and societal m...

    Authors: Adele S. Benzaken, Gerson F. M. Pereira, Lendel Costa, Amilcar Tanuri, André F. Santos and Marcelo A. Soares

    Citation: AIDS Research and Therapy 2019 16:19

    Content type: Review

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  36. People living with HIV (PLHIV) constantly need to address social issues such as the cost of accessing care, stigma, and lack of social support which impacts on their level of adherence to clinic visits or anti...

    Authors: Babatunde Adelekan, Nifarta Andrew, Iboro Nta, Asabe Gomwalk, Nicaise Ndembi, Charles Mensah, Patrick Dakum and Ahmad Aliyu

    Citation: AIDS Research and Therapy 2019 16:17

    Content type: Research

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  38. Human herpes virus 8 (HHV8) is the causative agent of Kaposi’s sarcoma and has been associated with an increasing number of hematologic diseases such as primary effusion lymphoma (PEL) (both classic and extrac...

    Authors: Laura Campogiani, Carlotta Cerva, Gaetano Maffongelli, Elisabetta Teti, Livio Pupo, Sara Vaccarini, Maria Cantonetti, Alfredo Pennica, Massimo Andreoni and Loredana Sarmati

    Citation: AIDS Research and Therapy 2019 16:15

    Content type: Case Report

    Published on:

  39. Infection with the human immunodeficiency virus (HIV) is an alarming problem in North African countries, but few studies have analyzed the geographical distribution of the epidemic. Libya, the second largest c...

    Authors: Mohamed A. Daw, Amina M. Daw, Nadia E. M. Sifennasr, Aisha M. Draha, Ahmed A. Daw, Ali A. Daw, Mohamed O. Ahmed, Ebtisam S. Mokhtar, Abdallah Hu. El-Bouzedi, Ibrahem M. Daw, Samia I. Adam and Saed Warrag

    Citation: AIDS Research and Therapy 2019 16:14

    Content type: Research

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  40. Men who have sex with men (MSM) are amongst populations at-risk for HIV acquisition in Thailand. In youth MSM (aged 15–24 years), the incidence of HIV infection has substantially increased. However, data on HI...

    Authors: Thana Khawcharoenporn, Suteera Mongkolkaewsub, Chanon Naijitra, Worawoot Khonphiern, Anucha Apisarnthanarak and Nittaya Phanuphak

    Citation: AIDS Research and Therapy 2019 16:13

    Content type: Research

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  41. Data on chronic kidney disease development in HIV infection is important towards building a comprehensive knowledge of HIV, ageing and polypharmacy in Africa. Several previous studies on tenofovir-associated k...

    Authors: Takudzwa J. Mtisi, Chiratidzo E. Ndhlovu, Chiedza C. Maponga and Gene D. Morse

    Citation: AIDS Research and Therapy 2019 16:12

    Content type: Review

    Published on:

  42. As in non-infected subjects, statins and aspirin have a pivotal preventive role in reducing the cardiovascular related morbidity and mortality in HIV infected patients. The persistence of immune activation in ...

    Authors: P. Maggi, G. V. De Socio, S. Cicalini, M. D’Abbraccio, G. Dettorre, A. Di Biagio, C. Martinelli, G. Nunnari, S. Rusconi, L. Sighinolfi, V. Spagnuolo and N. Squillace

    Citation: AIDS Research and Therapy 2019 16:11

    Content type: Methodology

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  43. Presence of isolated anti-HBc antibody is common in HIV-infected patients in endemic areas and could be caused by prior HBV infection with loss of anti-HBs antibody. The role of vaccination in these patients r...

    Authors: Nattinee Laksananun, Jutarat Praparattanapan, Wilai Kotarathititum, Khuanchai Supparatpinyo and Romanee Chaiwarith

    Citation: AIDS Research and Therapy 2019 16:10

    Content type: Research

    Published on:

  44. Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neu...

    Authors: Lai Gwen Chan, Mei Jing Ho, Yijun Carol Lin, Yining Ong and Chen Seong Wong

    Citation: AIDS Research and Therapy 2019 16:9

    Content type: Research

    Published on:

  45. The World Health Organization and Tanzanian National Guidelines for HIV and AIDS management, recommends provider initiated testing and counseling for HIV at any point of health care contact. In Tanzania, over ...

    Authors: Juma Ramadhani, Hendry R. Sawe, Said S. Kilindimo, Juma A. Mfinanga and Ellen J. Weber

    Citation: AIDS Research and Therapy 2019 16:8

    Content type: Research

    Published on:

  46. Long-term success of cART is possible if the regimen is convenient and less-toxic. This study assessed the efficacy and safety of switching from a first-line NNRTI or boosted PI-based regimens to RPV-based reg...

    Authors: Sivaporn Gatechompol, Anchalee Avihingsanon, Tanakorn Apornpong, Win Min Han, Stephen J. Kerr and Kiat Ruxrungtham

    Citation: AIDS Research and Therapy 2019 16:7

    Content type: Research

    Published on:

  47. This study aimed to investigate the prevalence of HIV late presentation and advanced HIV disease and to identify the factors associated with HIV late presentation and advanced HIV disease among patients with n...

    Authors: Xi Hu, Bingyu Liang, Chongxing Zhou, Junjun Jiang, Jiegang Huang, Chuanyi Ning, Jie Liu, Bo Zhou, Ning Zang, Jinzhen Lai, Rongfeng Chen, Yanyan Liao, Peijiang Pan, Xin Liu, Guanghua Lan, Xianwu Pang…

    Citation: AIDS Research and Therapy 2019 16:6

    Content type: Research

    Published on:

  48. High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG...

    Authors: Sarah E. Rutstein, Jane S. Chen, Julie A. E. Nelson, Samuel Phiri, William C. Miller and Mina C. Hosseinipour

    Citation: AIDS Research and Therapy 2019 16:5

    Content type: Short Report

    Published on:

  49. Despite the advances in therapy, the occurrence of drug-resistant human immunodeficiency virus type 1 (HIV-1) is a major obstacle to successful treatment. This study aimed to characterize the genetic diversity...

    Authors: Larissa Danielle Bahls, Pedro Henrique Canezin, Edna Maria Vissoci Reiche, José Carlos Couto Fernandez, José Ricardo Colleti Dias, Vera Alice Fernandes Meneguetti, Luis Toshio Ueda and Dennis Armando Bertolini

    Citation: AIDS Research and Therapy 2019 16:4

    Content type: Research

    Published on:

  50. Our understanding of HIV-1 and antiretroviral treatment (ART) is strongly biased towards subtype B, the predominant subtype in North America and western Europe. Efforts to characterize the response to first-li...

    Authors: Art F. Y. Poon, Emmanuel Ndashimye, Mariano Avino, Richard Gibson, Cissy Kityo, Fred Kyeyune, Immaculate Nankya, Miguel E. Quiñones-Mateu and Eric J. ARTS

    Citation: AIDS Research and Therapy 2019 16:3

    Content type: Research

    Published on:

  • ISSN: 1742-6405 (electronic)

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