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Research
Clinicians are incorporating patient-reported outcomes in the management of HIV-infected persons co-infected with hepatitis C virus (HCV), but there are no validated inventories to monitor symptoms of patients...
AIDS Research and Therapy 2017 14:56
Published on: 20 September 2017
Review
The success of many current vaccines relies on a formulation that incorporates an immune activating adjuvant. This will hold true for the design of a successful therapeutic HIV vaccine targeted at controlling ...
AIDS Research and Therapy 2017 14:53
Published on: 12 September 2017
Review
Collective evidence supporting a role of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in controlling HIV-1 transmission and disease progression emerged in the last few years. Non-neutralizing antibodie...
AIDS Research and Therapy 2017 14:42
Published on: 12 September 2017
Review
Despite the tremendous success of anti-retroviral therapy (ART) no current treatment can eradicate latent HIV reservoirs from HIV-infected individuals or generate, effective HIV-specific immunity. Technologica...
AIDS Research and Therapy 2017 14:40
Published on: 12 September 2017
Review
The anti-HIV activity of natural killer (NK) cells could be induced fast enough to potentially prevent the establishment of HIV infection. Epidemiological studies identified two genotypes encoding NK receptors...
AIDS Research and Therapy 2017 14:38
Published on: 12 September 2017
Review
Finding new adjuvants is an integrated component of the efforts in developing an effective HIV-1 vaccine. Compared with traditional adjuvants, a modern adjuvant in the context of HIV-1 prevention would elicit ...
AIDS Research and Therapy 2017 14:43
Published on: 12 September 2017
Review
Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the und...
AIDS Research and Therapy 2017 14:45
Published on: 12 September 2017
Editorial
AIDS Research and Therapy 2017 14:54
Published on: 12 September 2017
Review
HIV preferentially infects activated CD4+ T cells and mutates rapidly. The classical vaccine approach aimed to generate broad immune responses to full HIV proteins largely failed to address the potential adver...
AIDS Research and Therapy 2017 14:51
Published on: 12 September 2017
Review
Circumcision reduces heterosexual HIV-1 acquisition in men by at least 60%. However, the biological mechanisms by which circumcision is protective remain incompletely understood. We test the hypothesis that th...
AIDS Research and Therapy 2017 14:49
Published on: 12 September 2017
Review
Chronic infection with human immunodeficiency virus (HIV) causes HIV-specific CD8+ T cell dysfunction and exhaustion. The strong association between non-progression and maintenance of HIV-specific CD8+ T cell cyt...
AIDS Research and Therapy 2017 14:41
Published on: 12 September 2017
Review
Vesicular stomatitis virus (VSV), like many other Rhabdoviruses, have become the focus of intense research over the past couple of decades based on their suitability as vaccine vectors, transient gene delivery...
AIDS Research and Therapy 2017 14:55
Published on: 12 September 2017
Review
The quest for an effective HIV-1 vaccine began as soon as the virus causing AIDS was identified. After several disappointing attempts, results of the Phase-III RV144 trial in Thailand were a beacon of hope for...
AIDS Research and Therapy 2017 14:48
Published on: 12 September 2017
Review
The development of an efficient prophylactic HIV vaccine has been one of the major challenges in infectious disease research during the last three decades. Here, we present a mini review on strategies employed...
AIDS Research and Therapy 2017 14:47
Published on: 12 September 2017
Review
While the prevalence of Human immunodeficiency virus-1 (HIV-1) infection has stabilized globally, it continues to be the leading cause of death among women of reproductive age. The majority of new infections a...
AIDS Research and Therapy 2017 14:39
Published on: 12 September 2017
Review
APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally muta...
AIDS Research and Therapy 2017 14:44
Published on: 12 September 2017
Review
For over three decades, HIV infection has had a tremendous impact on the lives of individuals and public health. Microbicides and vaccines studies have shown that immune activation at the genital tract is a ri...
AIDS Research and Therapy 2017 14:46
Published on: 12 September 2017
Review
The extreme HIV diversity posts a great challenge on development of an effective anti-HIV vaccine. To solve this problem, it is crucial to discover an appropriate immunogens and strategies that are able to pre...
AIDS Research and Therapy 2017 14:50
Published on: 12 September 2017
Short Report
We present a small longitudinal study of how demographic factors and persistent burdens of HIV and cytomegalovirus (CMV) influence cardiovascular health in young adults beginning ART in an inner-city clinic in...
AIDS Research and Therapy 2017 14:52
Published on: 31 August 2017
Research
We hypothesized that frailty acts as a measure of health outcomes in the context of LT. The aim of this study was to explore frailty index across LT, as a measure of morbidity and mortality. This was a retrosp...
AIDS Research and Therapy 2017 14:37
Published on: 5 August 2017
Research
Combination antiretroviral therapy (cART) has significantly reduced HIV morbidity and mortality in both developed and developing countries. However, the sustainability of cART may be compromised by the emergen...
AIDS Research and Therapy 2017 14:36
Published on: 27 July 2017
Review
Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors se...
AIDS Research and Therapy 2017 14:35
Published on: 26 July 2017
Research
Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine were evaluated in HIV-positive Spanish MSM. The prevalence of High Squamous Intraepithelial Lesions (HSIL) and genotypes of hig...
AIDS Research and Therapy 2017 14:34
Published on: 18 July 2017
Research
Preparing adolescents for transition into adult care and supporting their acquisition of self-health care management skills is a critical determinant of their post-transition HIV care outcomes. However, there ...
AIDS Research and Therapy 2017 14:33
Published on: 17 July 2017
Review
Current treatment for HIV-1 largely relies on chemotherapy through the administration of antiretroviral drugs. While the search for anti-HIV-1 vaccine remain elusive, the use of highly active antiretroviral th...
AIDS Research and Therapy 2017 14:32
Published on: 14 July 2017
