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  1. The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children. We evaluated drug resistance mutations at 39 codon sites ...

    Authors: Susan A Fiscus, Andrea Kovacs, Leslie A Petch, Chengcheng Hu, Andrew A Wiznia, Lynne M Mofenson, Ram Yogev, Kenneth McIntosh, Stephen I Pelton, Sonia Napravnik, Kenneth Stanley and Sharon A Nachman
    Citation: AIDS Research and Therapy 2007 4:2
    Content type: Research Published on:

  2. CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs)...

    Authors: David M Moore, Anna Awor, Robert S Downing, Willy Were, Peter Solberg, David Tu, Keith Chan, Robert S Hogg and Jonathan Mermin
    Citation: AIDS Research and Therapy 2007 4:1
    Content type: Research Published on:

  3. We evaluated whether FLAVORx helped thirty Thai children take opened capsule, crushed tablets and liquid generic ARVs with more ease. All children had excellent adherence, evaluated by PACTG Standard Internati...

    Authors: Torsak Bunupuradah, Siripan Wannachai, Arpa Chuamchaitrakool, Jintana Intasan, Thantip Nuchapong, Woodie Neiss, Kenny Kramm, Chitsanu Pancharoen, David Burger and Jintanat Ananworanich
    Citation: AIDS Research and Therapy 2006 3:30
    Content type: Short report Published on:

  4. A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treat...

    Authors: Peter Emau, Yonghou Jiang, Michael B Agy, Baoping Tian, Girma Bekele and Che-Chung Tsai
    Citation: AIDS Research and Therapy 2006 3:29
    Content type: Research Published on:

  5. HLA-G gene is a non-classical MHC class 1 molecule that is highly expressed in the trophoblast at the maternal-fetal interface. In an attempt to elucidate possible immunological mechanisms facilitating protection...

    Authors: Felix O Aikhionbare, K Kumaresan, Falah Shamsa and Vincent C Bond
    Citation: AIDS Research and Therapy 2006 3:28
    Content type: Research Published on:

  6. Women continue to be disproportionately affected by HIV in Tanzania, and factors contributing to this situation need to be identified. The objective of this study was to determine social, behavioral and biolog...

    Authors: Sia E Msuya, Elizabeth Mbizvo, Akhtar Hussain, Jacqueline Uriyo, Noel E Sam and Babill Stray-Pedersen
    Citation: AIDS Research and Therapy 2006 3:27
    Content type: Research Published on:

  7. The CD4+ T cell count estimation is an important monitoring tool for HIV disease progression and efficacy of anti-retroviral treatment (ART). Due to availability of ART at low cost in developing countries, que...

    Authors: Madhuri R Thakar, Kishore B Kumar, Bharati A Mahajan, Sanjay M Mehendale and Ramesh S Paranjape
    Citation: AIDS Research and Therapy 2006 3:26
    Content type: Research Published on:

  8. Current HIV/AIDS statistics show that women account for almost 60% of HIV infections in Sub-Saharan Africa. HIV prevention tools such as male and female condoms, abstinence and monogamy are not always feasible...

    Authors: Gita Ramjee, Robin Shattock, Sinead Delany, Ian McGowan, Neetha Morar and Megan Gottemoeller
    Citation: AIDS Research and Therapy 2006 3:25
    Content type: Short report Published on:

  11. Despite multiple sexual exposure to HIV-1 virus, some individuals remain HIV-1 seronegative (exposed seronegative, ESN). The mechanisms underlying this resistance remain still unclear, although a multifactoria...

    Authors: Enrico M Trecarichi, Mario Tumbarello, Katleen de Gaetano Donati, Enrica Tamburrini, Roberto Cauda, Christina Brahe and Francesco D Tiziano
    Citation: AIDS Research and Therapy 2006 3:22
    Content type: Short report Published on:

  12. During HIV-1 infection, cytotoxic T cell (CTL) responses exert strong selective pressure on the replicating virus population. Here we report evidence for T cell activity against the drug resistant K103N region...

    Authors: Lisa Mahnke and David Clifford
    Citation: AIDS Research and Therapy 2006 3:21
    Content type: Short report Published on:

  14. The study assessed the effect of some highly active antiretroviral therapies (HAART), used in the management of HIV/AIDS in Cameroon, on oxidative stress markers such as malondialdehyde (as TBARs), albumin, pr...

    Authors: Judith L Ngondi, Julius Oben, David Musoro Forkah, Lucten Honore Etame and Dora Mbanya
    Citation: AIDS Research and Therapy 2006 3:19
    Content type: Research Published on:

  15. Diminished IL-2 production and lack of effector differentiation have been reported for HIV-specific T cells. In this study, we examined the prevalence of these phenomena using 8-color cytokine flow cytometry, ...

    Authors: Laurel E Nomura, Brinda Emu, Rebecca Hoh, Perry Haaland, Steven G Deeks, Jeffrey N Martin, Joseph M McCune, Douglas F Nixon and Holden T Maecker
    Citation: AIDS Research and Therapy 2006 3:18
    Content type: Research Published on:

  16. HIV lipodystrophy syndrome is a recognized complication of potent antiretroviral therapy and is characterized by often dramatic changes in various body fat stores, both central and peripheral. Given prior find...

    Authors: Jeannie S Huang, Shawn Harrity, Daniel Lee, Karen Becerra, Rosanne Santos and WChristopher Mathews
    Citation: AIDS Research and Therapy 2006 3:17
    Content type: Research Published on:

  17. We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia.

    Authors: Rupinderjeet Kaur, Roger Bedimo, Mary Beth Kvanli, Diana Turner, Leslie Shaw and David Margolis
    Citation: AIDS Research and Therapy 2006 3:16
    Content type: Short report Published on:

  18. The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been show...

    Authors: Elena E Paskaleva, Xudong Lin, Wen Li, Robin Cotter, Michael T Klein, Emily Roberge, Er K Yu, Bruce Clark, Jean-Claude Veille, Yanze Liu, David Y-W Lee and Mario Canki
    Citation: AIDS Research and Therapy 2006 3:15
    Content type: Research Published on:

  19. Although the impact of Aboriginal status on HIV incidence, HIV disease progression, and access to treatment has been investigated previously, little is known about the relationship between Aboriginal ethnicity...

    Authors: Viviane D Lima, Patricia Kretz, Anita Palepu, Simon Bonner, Thomas Kerr, David Moore, Mark Daniel, Julio SG Montaner and Robert S Hogg
    Citation: AIDS Research and Therapy 2006 3:14
    Content type: Research Published on:

  20. The Rev protein of the human immunodeficiency virus (HIV) facilitates the nuclear export of intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through the nucleolus and shuttl...

    Authors: Alessandro Michienzi, Fernanda G De Angelis, Irene Bozzoni and John J Rossi
    Citation: AIDS Research and Therapy 2006 3:13
    Content type: Research Published on:

  21. Current anti-AIDS therapeutic agents and treatment regimens can provide a dramatically improved quality of life for HIV-positive people, many of whom have no detectable viral load for prolonged periods of time...

    Authors: Li Wan, Xiaoping Zhang, Simi Gunaseelan, Shahriar Pooyan, Olivia Debrah, Michael J Leibowitz, Arnold B Rabson, Stanley Stein and Patrick J Sinko
    Citation: AIDS Research and Therapy 2006 3:12
    Content type: Research Published on:

  22. Efavirenz is the preferred non-nucleoside reverse transcriptase inhibitor for first-line antiretroviral treatment in many countries. For women of childbearing potential, advantages of efavirenz are balanced by...

    Authors: Matthew F Chersich, Michael F Urban, Francois WD Venter, Tina Wessels, Amanda Krause, Glenda E Gray, Stanley Luchters and Dennis L Viljoen
    Citation: AIDS Research and Therapy 2006 3:11
    Content type: Review Published on:

  23. Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuber...

    Authors: Degu Jerene, Are Næss and Bernt Lindtjørn
    Citation: AIDS Research and Therapy 2006 3:10
    Content type: Research Published on:

  24. Co-infection with hepatitis B virus (HBV) and human immunodeficiency virus (HIV) is not infrequent as both share same route of exposure. The risk of developing chronic hepatitis B virus is 6%, in general popul...

    Authors: Patricia Cornejo-Juárez, Patricia Volkow-Fernández, Kenia Escobedo-López, Diana Vilar-Compte, Guillermo Ruiz-Palacios and Luis Enrique Soto-Ramírez
    Citation: AIDS Research and Therapy 2006 3:9
    Content type: Research Published on:

  25. Co-infections of human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (M. Tb) are steadily increasing and represent a major health crisis in many developing countries. Both pathogens individually sti...

    Authors: Soichi Haraguchi, Noorbibi K Day, Wasu Kamchaisatian, Macarena Beigier-Pompadre, Steffen Stenger, Nutthapong Tangsinmankong, John W Sleasman, Salvatore V Pizzo and George J Cianciolo
    Citation: AIDS Research and Therapy 2006 3:8
    Content type: Research Published on:

  28. Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individual...

    Authors: Vishwanath Venketaraman, Tatanisha Rodgers, Rafael Linares, Nancy Reilly, Shobha Swaminathan, David Hom, Ariel C Millman, Robert Wallis and Nancy D Connell
    Citation: AIDS Research and Therapy 2006 3:5
    Content type: Research Published on:

  29. The objective of this study was to evaluate the safety of twice daily, intra-vaginal use of 0.5% PRO 2000 Gel for fourteen days in HIV un-infected women at lower as well as higher risk for HIV acquisition, in ...

    Authors: Joshi Smita, Dutta Soma, Bell Beverly, Profy Albert, Kuruc JoAnn, Gai Fang, Cianciola Missy, Soto-Torres Lydia, Panchanadikar Anjali, Risbud Arun, Mehendale Sanjay and Reynolds Steven J
    Citation: AIDS Research and Therapy 2006 3:4
    Content type: Research Published on:

  30. Partial or complete seroreversion for HIV-1, or incomplete antibody evolution are relatively rare events that have so far only been described in patients treated with HAART early after virus infection. Whether...

    Authors: Marion Cornelissen, Suzanne Jurriaans, Jan M Prins, Margreet Bakker and Antoinette C van der Kuyl
    Citation: AIDS Research and Therapy 2006 3:3
    Content type: Short report Published on:

  33. Protease inhibitors, particularly ritonavir, causes significant gastrointestinal disturbances such as nausea, even at low doses. This ritonavir-induced nausea could be related to its oxidative stress in the gu...

    Authors: Han Aung, Sangeeta Mehendale, Wei-Tien Chang, Chong-Zhi Wang, Jing-Tian Xie and Chun-Su Yuan
    Citation: AIDS Research and Therapy 2005 2:12
    Content type: Research Published on:

  35. Implementation of programs for the prevention of mother-to-child transmission (PMTCT) of HIV faces a variety of barriers and challenges. The assessment of these challenges has generally been conducted in large...

    Authors: Francis Bajunirwe and Michael Muzoora
    Citation: AIDS Research and Therapy 2005 2:10
    Content type: Research Published on:

  36. Episomal 2-long terminal repeat (LTR) HIV-1 cDNA, a by-product of HIV-1 infection, is used in clinical trials as a marker for ongoing viral replication. It would be useful to employ 2-LTR cDNA to monitor crypt...

    Authors: Chong Xu, Joseph A Politch, Kenneth H Mayer and Deborah J Anderson
    Citation: AIDS Research and Therapy 2005 2:9
    Content type: Research Published on:

  37. RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture. We previously reported m...

    Authors: Timothy S Fisher, Pheroze Joshi and Vinayaka R Prasad
    Citation: AIDS Research and Therapy 2005 2:8
    Content type: Research Published on:

  38. Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human ...

    Authors: Sandra Siegert, Sonja Thaler, Ralf Wagner and Barbara S Schnierle
    Citation: AIDS Research and Therapy 2005 2:7
    Content type: Methodology Published on:

  39. The neurofilament is a major structural component of myelinated axons. Increased cerebrospinal fluid (CSF) concentrations of the light chain of the neurofilament protein (NFL) can serve as a sensitive indicato...

    Authors: Magnus Gisslén, Lars Rosengren, Lars Hagberg, Steven G Deeks and Richard W Price
    Citation: AIDS Research and Therapy 2005 2:6
    Content type: Research Published on:

  40. In Cambodia, nearly half of pregnant women attend antenatal care (ANC), which is an entry point of services for prevention of mother-to-child transmission of HIV (PMTCT). However, most of ANC services are prov...

    Authors: Koum Kanal, Thai Leang Chou, Ly Sovann, Yasuo Morikawa, Yumi Mukoyama and Kazuhiro Kakimoto
    Citation: AIDS Research and Therapy 2005 2:5
    Content type: Short report Published on:

  41. Observational studies have suggested that low serum vitamin levels are associated with increased mother-to-child transmission (MTCT) of HIV and increased preterm delivery. We aimed to determine the efficacy of...

    Authors: Edward J Mills, Ping Wu, Dugald Seely and Gordon H Guyatt
    Citation: AIDS Research and Therapy 2005 2:4
    Content type: Research Published on:

  42. Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a u...

    Authors: Karen S Slobod, Chris Coleclough, Scott A Brown, John Stambas, Xiaoyan Zhan, Sherri Surman, Bart G Jones, Amy Zirkel, Pamela J Freiden, Brita Brown, Robert Sealy, Mattia Bonsignori and Julia L Hurwitz
    Citation: AIDS Research and Therapy 2005 2:3
    Content type: Hypothesis Published on:

  43. Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot...

    Authors: Heather A Baird, Andre J Marozsan, Michael M Lederman, Alan Landay, Donna Mildvan, Daniel R Kuritzkes, Harold A Kessler and Eric J Arts
    Citation: AIDS Research and Therapy 2005 2:2
    Content type: Research Published on:

  45. RNA based antiviral approaches against HIV-1 are among the most promising for long-term gene therapy. These include ribozymes, aptamers (decoys), and small interfering RNAs (siRNAs). Lentiviral vectors are ide...

    Authors: Akhil Banerjea, Ming-Jie Li, Leila Remling, John Rossi and Ramesh Akkina
    Citation: AIDS Research and Therapy 2004 1:2
    Content type: Research Published on:

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AIDS Research and Therapy

ISSN: 1742-6405

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