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  1. Appendicitis is a frequent surgical emergency worldwide. The present study was conducted to determine the prevalence of HIV, and the association of infection with clinical, intraoperative and histological find...

    Authors: Geofrey C Giiti, Humphrey D Mazigo, Jorg Heukelbach and William Mahalu

    Citation: AIDS Research and Therapy 2010 7:47

    Content type: Research

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  2. Highly active antiretroviral therapy (HAART) improves the immune function and decreases morbidity, mortality and opportunistic infections (OIs) in HIV-infected patients. However, since the use of HAART, immune...

    Authors: Kahsay Huruy, Afework Kassu, Andargachew Mulu and Yemataw Wondie

    Citation: AIDS Research and Therapy 2010 7:46

    Content type: Research

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  3. We assessed CD4 count at initial presentation for HIV care among ≥50-year-olds from 1997-2007 in 13 US and Canadian clinical cohorts and compared to <50-year-olds. 44,491 HIV-infected individuals in the North ...

    Authors: Keri N Althoff, Kelly A Gebo, Stephen J Gange, Marina B Klein, John T Brooks, Robert S Hogg, Ronald J Bosch, Michael A Horberg, Michael S Saag, Mari M Kitahata, Joseph J Eron, Sonia Napravnik, Sean B Rourke, M John Gill, Benigno Rodriguez, Timothy R Sterling…

    Citation: AIDS Research and Therapy 2010 7:45

    Content type: Short report

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  4. In the HAART era, the incidence of HIV-associated non-Hodgkin lymphoma (NHL) is decreasing. We describe cases of NHL among patients with multi-class antiretroviral resistance diagnosed rapidly after initiating...

    Authors: Gregory D Huhn, Sheila Badri, Sonia Vibhakar, Frank Tverdek, Christopher Crank, Ronald Lubelchek, Blake Max, David Simon, Beverly Sha, Oluwatoyin Adeyemi, Patricia Herrera, Allan Tenorio, Harold Kessler and David Barker

    Citation: AIDS Research and Therapy 2010 7:44

    Content type: Short report

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  5. The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the br...

    Authors: Alexander G Holman, Megan E Mefford, Niall O'Connor and Dana Gabuzda

    Citation: AIDS Research and Therapy 2010 7:43

    Content type: Research

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  6. Although antiretroviral therapy (ART) has proven its success against HIV-1, the long lifespan of infected cells and viral latency prevent eradication. In this study we analyzed the sensitivity to ART of HIV-1 ...

    Authors: Edwin J Heeregrave, Mark J Geels, Elly Baan, Renee M van der Sluis, William A Paxton and Georgios Pollakis

    Citation: AIDS Research and Therapy 2010 7:42

    Content type: Research

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  7. Vitamin D is an important determinant of bone health and also plays a major role in the regulation of the immune system. Interestingly, vitamin D status before the start of highly active antiretroviral therapy...

    Authors: Anali Conesa-Botella, Eric Florence, Lutgarde Lynen, Robert Colebunders, Joris Menten and Rodrigo Moreno-Reyes

    Citation: AIDS Research and Therapy 2010 7:40

    Content type: Research

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  8. Good adherence to antiretroviral therapy is necessary to achieve the best virological response, lower the risk that drug resistance will develop, and reduce morbidity and mortality. Little is known about the r...

    Authors: Ayele Tiyou, Tefera Belachew, Fisehaye Alemseged and Sibhatu Biadgilign

    Citation: AIDS Research and Therapy 2010 7:39

    Content type: Research

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  9. As second-line antiretroviral treatment (ART) becomes more accessible in resource-limited settings (RLS), the need for more affordable monitoring tools such as point-of-care viral load assays and simplified ge...

    Authors: Kim Steegen, Michelle Bronze, Elke Van Craenenbroeck, Bart Winters, Koen Van der Borght, Carole L Wallis, Wendy Stevens, Tobias F Rinke de Wit and Lieven J Stuyver

    Citation: AIDS Research and Therapy 2010 7:38

    Content type: Research

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  10. During stavudine phase-out plan in developing countries, tenofovir is used to substitute stavudine. However, knowledge regarding whether there is any difference of the frequency of renal injury between tenofov...

    Authors: Weerawat Manosuthi, Wiroj Mankatitham, Aroon Lueangniyomkul, Wisit Prasithsirikul, Preecha Tantanathip, Busakorn Suntisuklappon, Anongnuch Narkksoksung, Samruay Nilkamhang and Somnuek Sungkanuparph

    Citation: AIDS Research and Therapy 2010 7:37

    Content type: Research

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  11. Immune reconstitution inflammatory syndrome (IRIS) is an important complication of HAART in sub-Saharan Africa, where opportunistic infections (OIs) including mycobacteria and cryptococcus are common. The immu...

    Authors: Catherine M Worsley, Melinda S Suchard, Wendy S Stevens, Annelies Van Rie and David M Murdoch

    Citation: AIDS Research and Therapy 2010 7:36

    Content type: Research

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  12. We present an innovative approach to healthcare worker (HCW) training using mobile phones as a personal learning environment.

    Authors: Maria Zolfo, David Iglesias, Carlos Kiyan, Juan Echevarria, Luis Fucay, Ellar Llacsahuanga, Inge de Waard, Victor Suàrez, Walter Castillo Llaque and Lutgarde Lynen

    Citation: AIDS Research and Therapy 2010 7:35

    Content type: Research

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  13. Lipoprotein profiles in HIV-infected African women have not been well described. We assessed associations of lipoprotein levels and cardiovascular risk with HIV-infection and CD4 count in Rwandan women.

    Authors: Kathryn Anastos, François Ndamage, Dalian Lu, Mardge H Cohen, Qiuhu Shi, Jason Lazar, Venerand Bigirimana and Eugene Mutimura

    Citation: AIDS Research and Therapy 2010 7:34

    Content type: Research

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  14. Few data are available to guide programmatic solutions to the overlapping problems of undernutrition and HIV infection. We evaluated the impact of food assistance on patient outcomes in a comprehensive HIV pro...

    Authors: Louise C Ivers, Yuchiao Chang, J Gregory Jerome and Kenneth A Freedberg

    Citation: AIDS Research and Therapy 2010 7:33

    Content type: Research

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  15. The 516G > T polymorphism in exon 4 of the CYP2B6 gene has been associated with increased plasma Efavirenz (EFV) concentrations. EFV concentrations greater than the recommended therapeutic range have been associa...

    Authors: Verena Gounden, Chantal van Niekerk, Tracy Snyman and Jaya A George

    Citation: AIDS Research and Therapy 2010 7:32

    Content type: Research

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  16. A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration ...

    Authors: Aviad Levin, Zvi Hayouka, Assaf Friedler and Abraham Loyter

    Citation: AIDS Research and Therapy 2010 7:31

    Content type: Short report

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  17. Effective antiretroviral therapy reduces HIV-1 RNA levels, improves CD4 T-cell counts, and lowers the risk of opportunistic infections and malignancies. Interleukin-2 (IL-2) has been shown to increase CD4 T-ce...

    Authors: Ronald J Bosch, Richard B Pollard, Alan Landay, Evgenia Aga, Lawrence Fox and Ronald Mitsuyasu

    Citation: AIDS Research and Therapy 2010 7:30

    Content type: Research

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  18. This study aimed to evaluate the prevalence and predictors of AIDS-related complicated cryptococcal meningitis. The outcome was complicated cryptococcal meningitis: prolonged (≥ 14 days) altered mental status,...

    Authors: Edward R Cachay, Joseph Caperna, Amy M Sitapati, Hamta Jafari, Sean Kandel and William C Mathews

    Citation: AIDS Research and Therapy 2010 7:29

    Content type: Research

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  19. HIV-1 Rev protein regulates the expression of HIV-1 transcripts by binding to a highly structured stem loop structure called the Rev Responsive Element (RRE) present in the genomic and partially spliced RNAs. ...

    Authors: Yogeshwar Sharma, Ujjwal Neogi, Vikas Sood, Snigdha Banerjee, Subodh Samrat, Ajay Wanchu, Surjit Singh and Akhil C Banerjea

    Citation: AIDS Research and Therapy 2010 7:28

    Content type: Research

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  20. Nef is a 27 KDa HIV-1 accessory protein. It downregulates CD4 from infected cell surface, a mechanism critical for efficient viral replication and pathogenicity. Agents that antagonize the Nef-mediated CD4 dow...

    Authors: Yong-Jiu Jin, Xiaoping Zhang, Catherine Yi Cai and Steven J Burakoff

    Citation: AIDS Research and Therapy 2010 7:26

    Content type: Research

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  21. Recent studies have shown that the current guidelines suggesting immunologic monitoring to determine response to highly active antiretroviral therapy (HAART) are inadequate. We assessed whether routinely colle...

    Authors: Bryan Lau, Geetanjali Chander, Stephen J Gange and Richard D Moore

    Citation: AIDS Research and Therapy 2010 7:25

    Content type: Research

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  22. Understanding co-receptor tropism of HIV-1 strains circulating in India will provide key analytical leverage for assessing the potential usefulness of newer antiretroviral drugs such as chemokine co-receptor a...

    Authors: Ujjwal Neogi, Sreenivasa B Prarthana, George D'Souza, Ayesha DeCosta, Vijesh S Kuttiatt, Udaykumar Ranga and Anita Shet

    Citation: AIDS Research and Therapy 2010 7:24

    Content type: Short report

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  23. Stavudine continues to be widely used in resource poor settings despite its toxicity. Our objective was to determine association between plasma stavudine concentrations and lipoatrophy, concentrations of gluco...

    Authors: Phumla Z Sinxadi, Jan-Stefan van der Walt, Helen M McIlleron, Motasim Badri, Peter J Smith, Joel A Dave, Naomi S Levitt and Gary Maartens

    Citation: AIDS Research and Therapy 2010 7:23

    Content type: Research

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  24. At present, there is no effective vaccine or other approved product for the prevention of sexually transmitted human immunodeficiency virus type 1 (HIV-1) infection. It has been reported that women in resource...

    Authors: Carol S Lackman-Smith, Beth A Snyder, Katherine M Marotte, Mark C Osterling, Marie K Mankowski, Maureen Jones, Lourdes Nieves-Duran, Nicola Richardson-Harman, James E Cummins Jr and Brigitte E Sanders-Beer

    Citation: AIDS Research and Therapy 2010 7:22

    Content type: Research

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  25. The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can i...

    Authors: Rachel Van Duyne, Irene Guendel, Kylene Kehn-Hall, Rebecca Easley, Zachary Klase, Chenglong Liu, Mary Young and Fatah Kashanchi

    Citation: AIDS Research and Therapy 2010 7:21

    Content type: Research

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  26. Long-term survival of HIV-1 infected individuals is usually achieved by continuous administration of combination antiretroviral therapy (ART). An exception to this scenario is represented by HIV-1 infected non...

    Authors: Claudia J Dembek, Sarah Kutscher, Silvia Heltai, Simone Allgayer, Priscilla Biswas, Silvia Ghezzi, Elisa Vicenzi, Dieter Hoffmann, Peter Reitmeir, Giuseppe Tambussi, Johannes R Bogner, Paolo Lusso, Hans-J Stellbrink, Elena Santagostino, Thomas Vollbrecht, Frank D Goebel…

    Citation: AIDS Research and Therapy 2010 7:20

    Content type: Research

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  27. Although access to antiretroviral therapy (ART) for the treatment of HIV has increased during the last decade, many patients are still in need of treatment. With limited funds to provide ART to millions of pat...

    Authors: Reshmie Ramautarsing and Jintanat Ananworanich

    Citation: AIDS Research and Therapy 2010 7:18

    Content type: Review

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  28. This report represents the first exploratory study of Chinese men who provide commercial sex services to other men ("money boys") in Jilin Province, People's Republic of China, through a convenience sample dra...

    Authors: Xiangdong Meng, Allen F Anderson, Lu Wang, Zhihe Li, Wei Guo, Zixuan Lee, Huixin Jin and Yong Cai

    Citation: AIDS Research and Therapy 2010 7:17

    Content type: Short report

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  29. HIV-1 in genital secretions may be opsonized by several molecules including complement components. Opsonized HIV-1 by complement enhances the infection of various mucosal target cells, such as dendritic cells ...

    Authors: Mohammad-Ali Jenabian, Héla Saïdi, Charlotte Charpentier, Hicham Bouhlal, Dominique Schols, Jan Balzarini, Thomas W Bell, Guido Vanham and Laurent Bélec

    Citation: AIDS Research and Therapy 2010 7:16

    Content type: Research

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  30. HIV-1 invades the central nervous system (CNS) in the context of acute infection, persists thereafter in the absence of treatment, and leads to chronic intrathecal immunoactivation that can be measured by the ...

    Authors: Lars Hagberg, Paola Cinque, Magnus Gisslen, Bruce J Brew, Serena Spudich, Arabella Bestetti, Richard W Price and Dietmar Fuchs

    Citation: AIDS Research and Therapy 2010 7:15

    Content type: Review

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  31. To examine the outcomes of highly-active antiretroviral therapy (HAART) for individuals with free access to healthcare, we evaluated 2327 patients in a cohort study composed of military personnel and beneficia...

    Authors: Vincent C Marconi, Greg A Grandits, Amy C Weintrob, Helen Chun, Michael L Landrum, Anuradha Ganesan, Jason F Okulicz, Nancy Crum-Cianflone, Robert J O'Connell, Alan Lifson, Glenn W Wortmann and Brian K Agan

    Citation: AIDS Research and Therapy 2010 7:14

    Content type: Research

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  32. Interventions to promote prevention and earlier diagnosis of severe symptomatic hyperlactataemia (SHL) were implemented in the Western Cape provincial antiretroviral programme (South Africa) from 2004. Interve...

    Authors: Charlotte Schutz, Andrew Boulle, Dave Stead, Kevin Rebe, Meg Osler and Graeme Meintjes

    Citation: AIDS Research and Therapy 2010 7:13

    Content type: Research

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  33. After the introduction of highly active antiretroviral therapies (HAART), an increased incidence of insulin resistance, diabetes mellitus (DM), and cardiovascular diseases has been described. The impact of suc...

    Authors: Diego Serraino, Silvia Bruzzone, Antonella Zucchetto, Barbara Suligoi, Angela De Paoli, Simona Pennazza, Laura Camoni, Luigino Dal Maso, Paoli De Paoli and Giovanni Rezza

    Citation: AIDS Research and Therapy 2010 7:11

    Content type: Short report

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  34. South Africa, with its scientific capacity, good infrastructure and high HIV incidence rates, is ideally positioned to conduct large-scale HIV prevention trials. The HIV Prevention Research Unit of the South A...

    Authors: Gita Ramjee, Nicola Coumi, Nozizwe Dladla-Qwabe, Shay Ganesh, Sharika Gappoo, Roshini Govinden, Vijayanand Guddera, Rashika Maharaj, Jothi Moodley, Neetha Morar, Sarita Naidoo and Thesla Palanee

    Citation: AIDS Research and Therapy 2010 7:10

    Content type: Research

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  35. Abacavir (ABC) treatment has been associated with an increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in HIV-infe...

    Authors: Eefje Jong, Joost CM Meijers, Eric CM van Gorp, C Arnold Spek and Jan W Mulder

    Citation: AIDS Research and Therapy 2010 7:9

    Content type: Short report

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  36. Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and nevirapine, the major core antiretroviral drugs for HIV in Thailand. Rifampicin, a critical component of tuberculosis (TB) therapy is a potent inducer of CYP...

    Authors: Sumonmal Uttayamakul, Sirirat Likanonsakul, Weerawat Manosuthi, Nuanjun Wichukchinda, Thareerat Kalambaheti, Emi E Nakayama, Tatsuo Shioda and Srisin Khusmith

    Citation: AIDS Research and Therapy 2010 7:8

    Content type: Research

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  37. Current therapy for human immunodeficiency virus (HIV-1) infection relies primarily on the administration of anti-retroviral nucleoside analogues, either alone or in combination with HIV-protease inhibitors. A...

    Authors: Irene Guendel, Emmanuel T Agbottah, Kylene Kehn-Hall and Fatah Kashanchi

    Citation: AIDS Research and Therapy 2010 7:7

    Content type: Research

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  38. Smoking prevalence in human immunodeficiency virus (HIV) positive subjects is about three times of that in the general population. However, whether the extremely high smoking prevalence in HIV-positive subject...

    Authors: Qu Cui, Sue Carruthers, Andrew McIvor, Fiona Smaill, Lehana Thabane and Marek Smieja

    Citation: AIDS Research and Therapy 2010 7:6

    Content type: Research

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  39. Ritonavir-boosted saquinavir (SQVr) is nowadays regarded as an alternative antiretroviral drug probably due to several drawbacks, such as its high pill burden, twice daily dosing and the requirement of 200 mg ...

    Authors: Luis F López-Cortés, Pompeyo Viciana, Rosa Ruiz-Valderas, Juan Pasquau, Josefa Ruiz, Fernando Lozano, Dolores Merino, Antonio Vergara, Alberto Terrón, Luis González, Antonio Rivero and Agustin Muñoz-Sanz

    Citation: AIDS Research and Therapy 2010 7:5

    Content type: Research

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  40. HIV-1 infected patients for whom standard gp160 phenotypic tropism testing failed are currently excluded from co-receptor antagonist treatment. To provide patients with maximal treatment options, massively par...

    Authors: Ina Vandenbroucke, Herwig Van Marck, Wendy Mostmans, Veerle Van Eygen, Evelien Rondelez, Kim Thys, Kurt Van Baelen, Katrien Fransen, Dolores Vaira, Kabamba Kabeya, Stephane De Wit, Eric Florence, Michel Moutschen, Linos Vandekerckhove, Chris Verhofstede and Lieven J Stuyver

    Citation: AIDS Research and Therapy 2010 7:4

    Content type: Research

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  41. International HIV guidelines have recently shifted from a medium-late to an early-start treatment strategy. As a consequence, more people will be eligible to Highly Active Antiretroviral Therapy (HAART). We es...

    Authors: Kjell Arne Johansson, Bjarne Robberstad and Ole Frithjof Norheim

    Citation: AIDS Research and Therapy 2010 7:3

    Content type: Research

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  42. Adequate antiretroviral drug potency is essential for obtaining therapeutic benefit, however, the behavioral aspects of proper adherence and readiness to medication, often determine therapeutic outcome. Theref...

    Authors: Belay Tessema, Fantahun Biadglegne, Andargachew Mulu, Assefa Getachew, Frank Emmrich and Ulrich Sack

    Citation: AIDS Research and Therapy 2010 7:2

    Content type: Research

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  43. A recent study reported a lower than expected specificity and positive predictive value of the rapid oral HIV test in the setting of routine emergency department (ED) screening. These results appeared inconsis...

    Authors: Jeremy Brown, Manya Magnus, Maggie Czarnogosrki and Vanessa Lee

    Citation: AIDS Research and Therapy 2010 7:1

    Content type: Research

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  44. Different strategies of ritonavir-boosted lopinavir monotherapy have been explored; however, data regarding salvage therapy among HIV-infected patients who failed nucleoside reverse transcriptase inhibitor (NR...

    Authors: Weerawat Manosuthi, Sasisopin Kiertiburanakul, Wannarat Amornnimit, Wisit Prasithsirikul, Supeda Thongyen, Samruay Nilkamhang, Kiat Ruxrungtham and Somnuek Sungkanuparph

    Citation: AIDS Research and Therapy 2009 6:30

    Content type: Research

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  45. Lopinavir/ritonavir (LPV/r) tablet compared to the soft gel capsule (SGC) formulation has no oleic acid or sorbitol, has no refrigeration or food-restriction requirements, and has less pharmacokinetic variabil...

    Authors: Ighovwerha Ofotokun, Susan K Chuck, Brian Schmotzer and Kelly L O'Neil

    Citation: AIDS Research and Therapy 2009 6:29

    Content type: Research

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  46. HIV-1 epidemic in India is largely driven by subtype C but other subtypes or recombinants have also been reported from several states of India. This is mainly due to the co-circulation of other genetic subtype...

    Authors: Ujjwal Neogi, Vikas Sood, Arpita Chowdhury, Shukla Das, Vishnampettai G Ramachandran, Vijesh K Sreedhar, Ajay Wanchu, Nilanjana Ghosh and Akhil C Banerjea

    Citation: AIDS Research and Therapy 2009 6:28

    Content type: Short report

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