Cytokines | Baseline | Change from baseline after pitavastatin | Change from baseline after placebo | P-value |
---|---|---|---|---|
IL-1β | 2.01 (1.71 –2.42) | 1.28 (0.39–2.87) | 0.99 (0.30 –1.88) | 0.820 |
IL-1ra | 153.80 (132.90–180.80) | 37.10 (− 13.40–81.50) | 33.10 (8.44 –105.00) | 0.865 |
IL-2 | 9.51 (6.32–11.16) | 2.16 (0.49–5.54) | 1.74 (0.65–3.54) | 0.872 |
IL-4 | 3.89 (3.46–4.70) | 1.82 (1.21–2.37) | 1.35 (1.08 –2.20) | 0.261 |
IL-6 | 7.66 (6.55 –9.50) | 6.73 (1.00–33.3) | 9.29 (0.09 –26.40) | 0.966 |
IL-7 | 20.59 (11.55–34.30) | − 0.32 (− 15.10–4.72) | 1.38 (− 12.70–11.70) | 0.560 |
IL-8 | 23.87 (20.81–29.57) | 57.00 (18.50–89.70) | 53.6 (5.03–171.00) | 0.551 |
IL-9 | 66.40 (53.63–76.46) | 42.1 (21.10–53.90) | 34.20 (14.80–66.00) | 0.922 |
IL-10 | 14.38 (3.38–17.04) | 2.19 (0.00–10.30) | 2.36 (0.00 –10.50) | 0.958 |
IL-12 | 19.24 (13.43–29.46) | 9.39 (1.16–14.80) | 8.94 (4.81–15.90) | 0.601 |
IL-13 | 1.60 (1.16 –2.18) | 1.23 (0.01–2.26) | 1.06 (0.00–1.79) | 0.768 |
IL-15 | 14.23 (11.49–19.67) | 0.00 (− 4.03–1.57) | 1.19 (− 2.34–3.14) | 0.086 |
IL-17 | 211.20 (167.1 – 244.5) | 173.00 (85.10–219.00) | 129.00 (68.8–199.00) | 0.747 |
Eotaxin | 90.88 (70.86 – 110.20) | 5.97 (− 6.60–17.70) | 8.76 (− 9.80 –17.90) | 0.790 |
Basic FGF | 85.25 (75.04–98.90) | 27.10 (18.30–36.60) | 20.50 (11.60–29.00) | 0.023 |
G-CSF | 70.84 (59.80–76.97) | 0.79 (− 11.40–10.80) | 4.90 (− 3.33 –8.48) | 0.622 |
GM-CSF | 57.01 (48.31–66.63) | 8.67 (0.24–14.40) | 3.52 (0.00–13.00) | 0.223 |
IFN-γ | 14.40 (14.40–74.01) | 0.00 (− 2.70–12.00) | 0.00 (0.00–34.30) | 0.269 |
IP-10 | 613.40 (466.00–921.90) | 133.00 (17.30–201.00) | 103.00 (20.70–158.00) | 0.870 |
MCP-1 | 121.70 (100.80–160.50) | − 18.00 (− 49.10 – 0.62) | − 29.8 (− 43.80–−7.81) | 0.520 |
MIP-1α | 3.64 (1.00 –4.42) | 6.64 (3.80–14.80) | 6.21 (3.56–20.90) | 0.716 |
MIP-1β | 443.90 (368.50–482.90) | 610.00 (188.00 –1618.00) | 762.00 (87.80–1702.00) | 0.368 |
PDGF-BB | 409.70 (319.40–521.90) | 359.00 (240.00–443.00) | 305.00 (143.00–423.00) | 0.601 |
RANTES | 7240.00 (5799.00–9174.00) | − 2626.00 (− 5815.00–−506.00) | −1226.00 (− 3419–236.00) | 0.107 |
TNF-α | 52.70 (43.67–60.75) | 25.10 (6.94–56.60) | 21.90 (7.85-37.20) | 0.475 |
VEGF | 103.20 (81.34–164.90) | 22.10 (− 12.10–47.90) | 23.20 (0.07 –54.70) | 0.331 |
hs-CRP | 1.19 (1.00 –1.86) | 0.12 (− 0.21–0.67) | 0.17 (− 0.27 –0.78) | 0.596 |