Fig. 3

Gene editing by CRISPR/Cas9. A CRISPR/Cas9 introduces double stranded breaks in the HIV-1 LTR and/or viral genes thereby inactivating the proviral genome. Use of multiple gRNAs results in excision or hypermutation of the target sites. B The host co-receptors CXCR4 or CCR5 can also be targeted for blocking viral entry into the host cell thus, stopping further infection