A nomogram for predicting paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis among HIV-infected individuals in China

Table 2 Univariate and multivariate Cox analysis of variables associated with the presence of paradoxical CM-IRIS

Variables	Univariate analysis		p-value	Multivariate analysis		p-value
Variables	HR	95% CI	p-value	HR	95% CI	p-value
Age	0.946	(0.894–1.000)	0.051	0.910	(0.846–0.980)	0.013
Consciousness disorder
Yes	1.077	(0.390–3.000)	0.887
No	1.000
Head imaging abnormal
Yes	0.436	(0.166–1.147)	0.093	0.547	(0.193–1.551)	0.257
No	1.000			1.000
Initiate HAART time
≤ 4 weeks	6.036	(2.289–15.920)	< 0.001	7.073	(2.472–20.242)	< 0.001
> 4 weeks	1.000			1.000
Increase in CD4 cell counts
≤ 4 folds	1.000	(0.944–6.095)	0.066	1.000	(1.092–8.546)	0.033
> 4 folds	2.399			3.055
HGB	0.978	(0.959–0.997)	0.030	0.980	(0.962–0.998)	0.031
CRP	1.010	(1.003–1.014)	0.004	1.013	(1.004–1.021)	0.002

The significance of bold emphasis indicate that this variable has a statistical difference between the two groups

ISSN: 1742-6405