Table 1 Study sample characteristics and factors associated with post-HCV cure cannabis use reduction (logistic regression model, ANRS HEPAVIH cohort, n = 140)
Variable | Total n (%) | Cannabis use reducers n (%) | Cannabis use non-reducers n (%) | p-value1 | Univariable analyses | Multivariable analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | p-value | aOR | 95% CI | p-value | |||||
Gender | 0.730 | |||||||||
Male | 104 (74.3) | 38 (76.0) | 66 (73.3) | 1.15 | 0.52–2.56 | 0.730 | ||||
Female | 36 (25.7) | 12 (24.0) | 24 (26.7) | 1 | ||||||
Age (median, [IQR]) (years) | 55.7 [53.0–58.5] | 56.1 [53.2–58.6] | 55.4 [52.9–58.5] | 0.995 | 1.00 | 0.93–1.07 | 0.984 | |||
HCV transmission mode | 0.123 | 0.130 | ||||||||
Drug injection | 91 (65.0) | 38 (76.0) | 53 (58.9) | 1 | ||||||
Sexual transmission | 23 (16.4) | 6 (12.0) | 17 (18.9) | 0.49 | 0.18–1.37 | 0.173 | ||||
Other | 26 (18.6) | 6 (12.0) | 20 (22.2) | 0.42 | 0.15–1.14 | 0.089 | ||||
Change in tobacco use2 | < 0.001 | < 0.001 | 0.014 | |||||||
No use | 9 (6.4) | 4 (8.0) | 5 (5.6) | 4.58 | 1.06–19.78 | 0.041 | 3.84 | 0.67–22.09 | 0.131 | |
Reduction | 57 (40.7) | 35 (70.0) | 22 (24.4) | 9.11 | 3.96–20.96 | < 0.001 | 4.32 | 1.58–11.78 | 0.004 | |
No reduction | 74 (52.9) | 11 (22.0) | 63 (70.0) | 1 | 1 | |||||
Change in alcohol use2 | < 0.001 | < 0.001 | 0.003 | |||||||
No use | 39 (27.9) | 22 (44.0) | 17 (18.9) | 9.54 | 3.61–25.24 | < 0.001 | 7.71 | 2.39–24.87 | < 0.001 | |
Reduction | 34 (24.3) | 20 (40.0) | 14 (15.6) | 10.54 | 3.85–28.81 | < 0.001 | 3.32 | 0.94–11.72 | 0.063 | |
No reduction | 67 (47.9) | 8 (16.0) | 59 (65.6) | 1 | 1 | |||||
Change in other substance use2 | 0.004 | 0.018 | ||||||||
No use | 108 (77.1) | 35 (70.0) | 73 (81.1) | 1.20 | 0.43–3.35 | 0.730 | ||||
Reduction | 11 (7.9) | 9 (18.0) | 2 (2.2) | 11.25 | 1.86–68.13 | 0.008 | ||||
No reduction | 21 (15.0) | 6 (12.0) | 15 (16.7) | 1 | ||||||
Changes in physical activity2 | 0.238 | 0.244 | ||||||||
Stable | 85 (60.7) | 26 (52.0) | 59 (65.6) | 1 | ||||||
Increase | 39 (27.9) | 16 (32.0) | 23 (25.6) | 1.58 | 0.72–3.47 | 0.256 | ||||
Reduction | 16 (11.4) | 8 (16.0) | 8 (8.9) | 2.27 | 0.77–6.70 | 0.138 | ||||
Changes in fatigue level2 | 0.021 | 0.023 | 0.073 | |||||||
Stable | 63 (45.0) | 15 (30.0) | 48 (53.3) | 1 | 1 | |||||
Reduction | 63 (45.0) | 30 (60.0) | 33 (36.7) | 2.91 | 1.36–6.23 | 0.006 | 3.12 | 1.15–8.46 | 0.025 | |
Increase | 14 (10.0) | 5 (10.0) | 9 (10.0) | 1.78 | 0.52–6.13 | 0.362 | 2.95 | 0.61–14.15 | 0.177 | |
Changes in dietary habits2 | < 0.001 | < 0.001 | 0.045 | |||||||
Stable | 92 (65.7) | 21 (42.0) | 71 (78.9) | 1 | 1 | |||||
Paying more attention | 40 (28.6) | 25 (50.0) | 15 (16.7) | 5.64 | 2.52–12.59 | < 0.001 | 3.33 | 1.22–9.14 | 0.019 | |
Paying less attention | 8 (5.7) | 4 (8.0) | 4 (4.4) | 3.38 | 0.78–14.69 | 0.104 | 3.01 | 0.48–18.79 | 0.237 | |
Change in body weight 2 | 0.073 | 0.078 | ||||||||
No change or reduction | 84 (60.0) | 24 (48.0) | 60 (66.7) | 1 | ||||||
Increase < 5 kg | 33 (23.6) | 14 (28.0) | 19 (21.1) | 1.84 | 0.80–4.25 | 0.153 | ||||
Increase ≥ 5 kg | 23 (16.4) | 12 (24.0) | 11 (12.2) | 2.73 | 1.06–7.02 | 0.038 | ||||