Skip to main content

Table 3 Laboratory values at baseline and at end of follow-up period

From: Safety and effectiveness of switching to Abacavir/Lamivudine plus rilpivirine for maintenance therapy in virologically suppressed HIV-1 individuals in Singapore (SEALS)

 

Median (IQR)

p-value

Laboratory parameter

 Absolute CD4 Count (n = 38)

Baseline (cells/uL)

323 (220 to 519)

 

Follow up (cells/uL)

397 (252 to 603)

 

Follow up Duration (Weeks)

49 (44 to 52)

 

Change (cells/uL)

31 (− 32 to + 141)

 < 0.01b

Glucose monitoring

 Fasting blood glucose (n = 11)

Baseline (mmol/L)

5.1 (4.9 to 5.7)

 

Follow Up (mmol/L)

5.2 (4.7 to 5.5)

 

Follow up Duration (Weeks)

50 (46 to 52)

 

Change (mmol/L)

0.3 (− 0.5 to + 0.4)

0.654b

 HbA1c (n = 8)

Baseline (%)

5.75 (5.55 to 6.5)

 

Follow Up (%)

5.85 (5.5 to 6.78)

 

Follow up Duration (Weeks)

50 (40 to 58)

 

Absolute Change (%)

0.05 (− 0.08 to + 0.2)

0.288a

Renal

 eGFR (n = 139)

Baseline (ml/min/1.73m2)

90 (78 to 104)

 

Follow Up (ml/min/1.73m2)

87 (76 to 99)

 

Follow up Duration (Weeks)

49 (40 to 54)

 

Change (ml/min/1.73m2)

− 4 (− 14 to 5)

 < 0.01b

 eCrCl (n = 139)

Baseline (ml/min)

91 (76 to 106)

 

Follow Up (ml/min)

90 (76 to 106)

 

Follow up Duration (Weeks)

49 (40 to 54)

 

Change (ml/min)

− 1 (− 9 to + 8)

0.423a

Lipids

 TC (n = 38)

Baseline (mmol/L)

5.1 (4.6 to 6.0)

 

Follow Up (mmol/L)

5.2 (4.4 to 5.8)

 

Follow up Duration (Weeks)

51 (45 to 54)

 

Change (mmol/L)

0.1 (− 1.1 to + 0.8)

0.778b

HDL-C (n = 38)

Baseline (mmol/L)

1.0 (0.9 to 1.4)

 

Follow Up (mmol/L)

1.2 (0.9 to 1.3)

 

Follow up Duration (Weeks)

50 (45 to 54)

 

Change (mmol/L)

0 (− 0.2 to + 0.2)

0.762b

 dC LDL-C (n = 38)

Baseline (mmol/L)

2.9 (2.6 to 3.6)

 

Follow Up (mmol/L)

2.8 (2.4 to 3.5)

 

Follow up Duration (Weeks)

51 (45 to 54)

 

Change (mmol/L)

− 0.1 (− 0.5 to + 0.5)

0.817b

 LDL-C (n = 35)

Baseline (mmol/L)

3.1 (2.6 to 3.7)

 

Follow Up (mmol/L)

3.1 (2.7 to 3.7)

 

Follow up Duration (Weeks)

51 (45 to 54)

 

Change (mmol/L)

0.1 (− 0.6 to + 0.7)

0.972b

Liver

 ALT (n = 117)

Baseline (U/L)

28 (21 to 44.5)

 

Follow Up (U/L)

22 (16 to 30)

 

Follow up Duration (Weeks)

48 (41 to 52)

 

Change (U/L)

− 6 (− 11 to + 0)

 < 0.001a

  1. eGFR Estimated glomerular filtration rate, eCrCl Estimated creatinine clearance, TC Total cholesterol, HDL-C High density lipoprotein cholesterol, dC LDL-C Low density lipoprotein cholesterol estimated with the de Cordova equation.  [21], LDL-C Low density lipoprotein cholesterol, ALT Alanine transaminase
  2. aWilcoxon signed rank test
  3. bPaired samples t-test