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Table 2 Cellular activities of ribonucleases

From: Ribonuclease zymogen induces cytotoxicity upon HIV-1 infection

Ribonuclease

Cell death (IC50)a

HIV inhibition (IC50)b

QBI-139

0.41 µM

0.34 µM

Str2-EV

8.7 µM

7.5 µM

  1. aDetermined after 7 days with a tetrazolium-dye based assay or
  2. bp24 ELISA