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Table 2 Factors associated with loss to follow up among patients initiated on second-line ART at MRRH HIV Clinic

From: Incidence and predictors of early loss to follow up among patients initiated on protease inhibitor-based second-line antiretroviral therapy in southwestern Uganda

Characteristic Active n (%) LTFU n (%) Unadjusted risk ratio [C I] p values Adjusted Risk Ratios [C.I] p values
Male gender 324 (79.8) 82 (20.2) 1.1 [1.02–1.2] 0.01 1.8 [1.5–2.0]  < 0.001
Age categories
 18–24 52 (77.6) 15 (33.4) 1    
 25–34 225 (82.7) 47 (17.3) 0.9 [0.8–1.1] 0.43
 35–49 398 (83.6) 78 (16.4) 0.9 [0.7–1.1] 0.19
  ≥ 50 80 (73.4) 29 (26.1) 1.3 [1.2–1.6]  < 0.001
Patient category
 Original cohort 587 (86.1) 95 (13.9) 1    
 Transfer in 168 (69.4) 74 (30.6) 1.9 [1.8–2.1]  < 0.001 0.9 [0.8–1.2] 0.62
CD4 categories
 < 100 371 (85.7) 62 (14.3) 1    
 100–250 219 (85.6) 37 (14.4) 1 [0.9–1.41] 0.63
 251–500 86 (86) 14 (14) 1 [0.9–1.3] 0.38
 > 500 35 (92.1) 3 (7.9) 0.4 [0.3–0.6]  < 0.001
Body-mass index Underweight
 Normal BMI 115 (78.8) 31 (21.2) 1    
 Overweight 390 (87.8) 54 (12.2) 0.6 [0.5–0.7]  < 0.01 0.8 [0.7–1.0] 0.03
 Obese 59 (90.8) 6 (9.2) 0.4 [0.3–0.5]  < 0.01 0.7 [0.5–1.0] 0.03
  25 (86.2) 4 (13.8) 0.3 [0.2–0.6]  < 0.01 0.2 [0.05–0.5] 0.001
Viral load
  < 1000 12 (80) 3 (20) 1    
 > 1000 390 (91.2) 39 (8.8) 0.4 [0.3–0.5]  < 0.001   
Hemoglobin
 No Anemia 422 (88.7) 54 (11.3) 1    
 Mild Anemia 138 (85.2) 24 (14.8) 1.3 [1.1–1.5]  < 0.001 1.4 [1.1–1.6]  < 0.001
 Moderate- Severe Anemia 111 (81) 26 (19) 1.8 (1.5–2.0)  < 0.001 1.4 [1.1–1.7]  < 0.001
Marital status
 Married 342 (80.1) 82 (19.3) 1    
 Single/widowed/ 364 (82.3) 78 (17.7) 0.9 (09–1.1) 0.84   
 Divorced       
HIV staging
 1 334 (87.4) 48 (12.6) 1   1  
 2 152 (85.9) 25 (14.1) 1.1 [0.6–1.5] 0.09 1.2 [1.0–1.4] 0.04
 3 165 (84.6) 30 (15.4) 1.2 [1.1–1.4] 0.06 0.9 [0.7–1.1] 0.22
 4 91 (79.8) 23 (20.2) 1.3 [1.1–1.5]  < 0.01 0.7 [0.5–1.0] 0.03
Year of Starting ART
 Before 2006 351 (79.1) 93 (20.9) 1    
 2006 to 2010 233 (83.8) 45 (16.2) 0.6 [0.5–0.7]  < 0.001 3.9 [2.9–5.3]  < 0.001
 2011 on wards 155 (87.1) 23 (12.9) 0.6 [0.5–0.7]  < 0.001 2.2 [1.7–3.0]  < 0.001
History of Kaposi
 Sarcoma 26 (78.8) 7 (21.2) 1.1 [0.9–21.5] 0.2   
 History of Tuberculosis 60 (82.2) 13 (17.8) 0.91 [0.7–1.0] 0.14   
 Switched due to Clinical Failurea 182 (71.1) 74 (28.9) 2.2 (2.1–2.4)  < 0.00   
  1. The Body Mass Index is the weight in kilograms divided by the square of the height in meters
  2. aClinical failure due to other opportunistic diseases other than Kaposi’s Sarcoma, Tuberculosis and Cryptococcal meningitis