Table 4 HIV-1 subtype C V3 loop N-glycosylation site and V3 loop crown motif variation in African countries

Zambia (ZM)

4.5

17.2

5

30

South Africa (ZA)

0.1

18.4

0.7

6.2

Tanzania (TZ)

0

0

0

0

Malawi (MW)

1.1

0

1.3

22.7

Ethiopia (ET)

6

67

1.7

46.9

Botswana (BW)

4

0

2

3

Variation at the GPGQ Crown motif (%)

 Zambia (ZM)

0

→ RPGQ (1.8)

→ GPRQ (1.8)

→ GPGR (0.2)

→ RPRQ (0.4)

→ RPGQ (0.5) → GPEQ (0.07)

→ GPGR (1.25)

→ RPGQ (6.3)

 South Africa (ZA)

 → GPGK (0.1)

 → GPGR (0.1)

0

→ GPGR (0.09)

→ GPGT (0.9)

→ GPGI (0.19)

→ GPGY (27.4)

→ GPGA (10.6)

→ GRGQ (7.1)

→ GPGT (4.4)

→ GRGQ (5.3)

→ GPGH (1.8)

→ GPRQ (1.8)

→ GPGL (0.9)

→ GQRQ (0.9)

 Tanzania (TZ)

0

0

→ GPGH (0.3)

→ GLGQ (1.1)

→ GSGQ (0.6)

0

 Malawi (MW)

0

→ GPGK (9.2)

→ GPGR (1.2)

→ GPGR (0.6)

→ GPGK (0.5)

→ GPGH (0.08)

→ EPGQ (0.04)

→ GRGH (0.04)

→ RPGQ (0.04)

→ GPGK (7.6)

→ RPGQ (0.8)

→ GSGQ (0.8)

 Ethiopia (ET)

0

0

→ GPRT (1.7)

→ RPRQ (1.7)

→ GPGH (43.8)

→ GRGQ (18.8)

 Botswana (BW)

→ GPGK (0.15)

→ GPGK (35.8)

→ GPGR (40.3)

→ GPGR (0.6)

→ RPGQ (0.3)

→ GQGQ (0.06)

→ GPGP (0.06)

→ GGGK (0.8)

→ GPGR (77)

→ GPGK (22.6)