Table 1 Co-receptor prediction using sequences from African HIV-1 subtype C early (< 6 months of seroconversion) and chronically (> 6 months of seroconversion) infected individuals
From: HIV-1 subtype C predicted co-receptor tropism in Africa: an individual sequence level meta-analysis
African countries | Predicted biotype | |||||
|---|---|---|---|---|---|---|
Early | Chronic | |||||
Total (%) | X4 (%) | R5 (%) | Total (%) | X4 (%) | R5 (%) | |
Total sequences analyzed | 6316 | 518 (8.2%; 95% CI 0.7–9.3) | 5798 (91.8%; 95% CI 90.7–99.3) | 7338 | 612 (8.34%; 95% CI 2.4–16.2) | 6726 (91.7%; 95% CI 84.8–97.5) |
Botswana (BW) | 1401 (22.2) | 68 (4.9) | 1333 (95.1) | 1604 (21.9) | 96 (6) | 1508 (94) |
Burundi (BI) | NA | NA | NA | 4 (0.05) | 0 | 4 (100) |
Congo (CD) | NA | NA | NA | 18 (0.25) | 0 | 18 (100) |
Ethiopia (ET) | 20 (0.32) | 3 (15) | 17 (85) | 164 (2.2) | 56 (34) | 108 (66) |
Gabon (GA) | NA | NA | NA | 2 (0.03) | 0 | 2 (100) |
Gambia (GM) | NA | NA | NA | 3 (0.04) | 1 (33.3) | 2 (66.6) |
Guinea-Bissau (GW) | NA | NA | NA | 7 (0.1) | 0 | 7 (100) |
Kenya (KE) | 2 (0.03) | 0 | 2 (100) | 12 (0.2) | 0 | 12 (100) |
Malawi (MW) | 2100 (33.2) | 339 (16.1) | 1761 (83.9) | 2591 (35.3) | 164 (6.3) | 2427 (93.7) |
Rwanda (RW) | 109 (3) | 0 | 109 (100) | 8 (0.1) | 0 | 8 (100) |
Senegal (SN) | 3 (0.06) | 0 | 3 (100) | NA | NA | NA |
South Africa (ZA) | 1246 (19.7) | 59 (4.7) | 1187 (95.3) | 1151 (15.7) | 121 (10.5) | 1030 (89.5) |
Tanzania (TZ) | 86 (1.4) | 5 (5.8) | 81 (94.2) | 376 (5.1) | 62 (16.5) | 314 (83.5) |
Zambia (ZM) | 1345 (21.3) | 44 (3.3) | 1301 (96.7) | 1353 (18.4) | 100 (7.4) | 1253 (92.6) |
Zimbabwe (ZW) | 4 (0.06) | 0 | 4 (100) | 44 (0.6) | 12 (26) | 32 (74) |
Uganda (UG) | NA | NA | NA | 1 (0.01) | 0 | 1 (100) |