Skip to main content

Table 2 Resistance-associated mutations (RAMs) and other substitutions found in the integrase region along with the susceptibility score

From: HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study

SubjectMajorAccessoryOtherScore RALScore EVGScore DTGScore BIC
1Y143RT97AL101I, V201I, S230N702555
2K111R, T125A, T206S, S230N, D232E0000
3I72V, L101I, T124A, V126T, I135V, F181L, V201I, K215N, D232E0000
4A80V, L101I, T112V, T124N, T125V, I141V, G163E, V201I, I203M0000
5G140S, Q148HL101I, T112A, T124A, T125A, I135V, K156N, D256E90904545
6E92Q, E138K, Y143HRL68V, L74M, S119T, V201I, S230N, D232E, L234F105903030
7L101I, K111R, T112S, R187K0000
8G140S, Y143R, Q148HL101I, K160N, L234I1501005050
9I113V, T124N, T125A, K211R, K219N, N222K, D232E, D253E0000
10V31I, M50L, L101I, T112I, V201I0000
11D25E, V31I, I72V, Y99F, L101I, T124A, T125A, I135V, G163T0000
12Y143HF1I, D3V, V31I, Q44P, I72V, I73T, L102FPS, G106A, S230N, D256E601055
13E157QS17N, A21E, A23V, L28I, P30A, S39C, I113V, T124A, T125A, K160R, V201I, L234I, W243G, D253E, S255N101000
14E138K, G140A, Q148KV31I, I72V, K111R, V201I, I208M, K215N, I220L1201208080
15L101I, K136N, V151I, V201I, T206S, E212V, K215N, D256E, S283G0000
16Y143RG163RV31I, L74M, Y99F, G106A, T112A, I113V, S123V, T124A, T125A, I204V, S230N, K240R75351515
17E92Q, N155HG163RV31I, L101I, T112AIV, T124A, E138D, V151I, K211R1051352525
18S24N, T124A, K160Q, V201I, S230N0000
19Y143C, N155HS230RK14R, V31I, E69Q, Y99F, L101I, S119T, T124A, I135V, G163E, K211R, L234V, D256E140954030
20N155HG163RT112A, T124A, I135V, V151I, K156R, V201I, I208M75751010
21N155HI72V, L101I, S119R, V151I, K156N, I208L, E212L, T218S60601010
22L68M, T122S, T124A, V151I, G193E, I208L0000
23N155HL101I, K111T, S119T, T124A, T125A, I208L60601010
24L101I, K111T, I113V, S119P, K211R, K219N, N222K, S230N0000
25I72V, I73V, A80V, L101I, K111R, T124A, E138D, G163V, G197W, R228K0000
  1. Stanford HIV Drug Resistance Database v8.8. N = 25
  2. RAMs resistance-associated mutations, RAL raltegravir, EVG elvitegravir, DTG dolutegravir, BIC bictegravir