Variable | n | Univariate analysis | P | Multivariate analysis | P |
---|---|---|---|---|---|
ADE | Â | Â | Â | Â | Â |
 No | 5618 | 1.00 |  | 1.00 |  |
 Yes | 1139 | 1.618 (1.356–1.931) | < 0.001 | 1.291 (1.061–1.571) | 0.011 |
Age |  |  | < 0.001 |  | < 0.001 |
 ≤ 40 | 1210 | 1.00 |  | 1.00 |  |
 40 < age ≤ 65 | 3734 | 2 (1.664–2.404) | < 0.001 | 2.068 (1.699–2.518) | < 0.001 |
 > 65 | 915 | 3.927 (3.191–4.831) | < 0.001 | 3.653 (2.896–4.607) | < 0.001 |
Gender | |||||
 Male | 4619 | 1.00 |  | 1.00 |  |
 Female | 2138 | 0.475 (0.394–0.574) | < 0.001 | 0.563 (0.463–0.686) | < 0.001 |
Marital status | Â | Â | 0.027 | Â | 0.069 |
 Unmarried | 715 | 1.00 |  | 1.00 |  |
 Married or living with a partner | 5026 | 1.171 (0.893–1.536) | 0.253 | 0.737 (0.551–0.985) | 0.039 |
 Divorced or widowed or other | 1016 | 1.462 (1.071–1.994) | 0.017 | 0.845 (0.601–1.187) | 0.331 |
Route of HIV infection | Â | Â | 0.372 | Â | Â |
 Blood or plasma transfusion | 352 | 1.00 |  |  |  |
 Sexually transmitted | 6104 | 1.205 (0.926–1.568) | 0.166 |  |  |
 Other or unknown | 301 | 1.139 (0.757–1.714) | 0.533 |  |  |
WHO clinical stage |  |  | < 0.001 |  | < 0.001 |
 I | 2510 | 1.00 |  | 1.00 |  |
 II | 1132 | 0.954 (0.733–1.242) | 0.727 | 0.863 (0.7061.055) | 0.150 |
 III | 1863 | 1.057 (0.847–1.319) | 0.625 | 1.095 (0.838–1.430) | 0.506 |
 IV | 1218 | 1.624 (1.281–2.058) | < 0.001 | 1.454 (1.092–1.935) | 0.01 |
Previous use of the cotrimoxazole | Â | Â | Â | Â | Â |
 Yes | 1879 | 1.00 |  | 1.00 |  |
 No | 4878 | 0.406 (0.34–0.486) | < 0.001 | 0.4880.403–0.592 | < 0.001 |
Initial antiretroviral regimen |  |  | < 0.001 |  | < 0.001 |
 2NRTIs + 1NNRTI | 5943 | 1.00 |  | 1.00 |  |
 2NRTIs + 1PI | 517 | 6.212 (4.762–8.103) | < 0.001 | 4.721 (3.577–6.23) | < 0.001 |
 Single or two drugs | 297 | 1.122 (0.844–1.49) | 0.428 | 1.163 (0.87–1.555) | 0.307 |
Baseline CD4+ cell count (cells/μL) |  |  | < 0.001 |  | < 0.001 |
 CD4 ≥ 350 | 835 | 1.00 |  | 1.00 |  |
 200 ≤ CD4 < 350 | 1796 | 0.742 (0.442–1.247) | 0.260 | 0.794 (0.468–1.345) | 0.39 |
 100 ≤ CD4 < 200 | 1430 | 1.263 (0.762–2.095) | 0.365 | 1.244 (0.739–2.094) | 0.41 |
 50 ≤ CD4 < 100 | 796 | 1.484 (0.886–2.487) | 0.134 | 1.56 (0.911–2.669) | 0.11 |
 CD4 < 50 | 1900 | 1.898 (1.162–3.103) | 0.011 | 1.846 (1.095–3.114) | 0.02 |