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Table 1 Clinical features, treatments and outcomes of the 10 patients of AIDS-associated T. marneffei CNS infections

From: AIDS-associated Talaromyces marneffei central nervous system infection in patients of southwestern China

Patient

Gender

Age, (years)

Job

Duration of illness (days)

Test sample

Presenting symptoms

Presenting sign(s)

Initiation treatment and maintenance therapy

Hospitalization time

Initial ART time and regimen

Outcomes and followed up

1

Male

37

Farmer

30

CSF

Headache, nausea, vomiting, irritability, unconsciousness, fever

Neck stiffness

Amphotericin B for 38 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)

September 1, 2009

Mar 2007

AZT/3TC/NVP

Improved

2

Female

38

Farmer

60

CSF

Dizziness, eyes distention, limbs fatigue

Amphotericin B for 42 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)

January 20, 2010

Sep 2003

AZT/3TC/NVP

Improved

3

Male

36

Farmer

30

CSF and blood

Fever, right limb dyskinesia

A muscle power 4 out of 5 for right limbs, skin lesion and oral mucosal papules

Amphotericin B for 31 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)

May 31, 2100

Initial 28 days after hospitalization

D4T/3TC/EFV

Improved

4

Male

47

Farmer

30

CSF

Headache, lower limb dyskinesia, hearing loss and diplopia

A muscle power 3 out of 5 for both lower limbs

Amphotericin B for 30 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)

April 16, 2013

Initial 29 days after hospitalization

AZT/3TC/LPV/r

Improved

5

Male

46

Farmer

30

CSF

Dizziness, nausea, vomiting, drowsiness

A muscle power 3 out of 5 for right lower limb

Amphotericin B for 34 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)

January 7, 2015

Jul 2010

AZT/3TC/NVP

Improved

6

Male

30

Unemployment

60

CSF

Dizziness, lower extremity fatigue

A muscle power 4 out of 5 for right lower limb

Amphotericin B for 23 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)

January 23, 2015

Dec 2005

AZT/3TC/EFV

Improved

7

Female

34

Worker

90

CSF and urine

Fever, headache, Left upper limb dyskinesia

A muscle power 3 out of 5 for left upper limb

Amphotericin B for 40 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)

May 9, 2012

Initial 18 days after hospitalization AZT/3TC/EFV

Improved

8

Female

24

Farmer

20

CSF, blood and bone marrow

Fever, dizziness, weight loss, anorexia, convulsions and coma

Anemia, skin lesion, oral mucosal papules and enlargement of neck lymph node

Fluconazole for 6 days (400 mg/day)

March 7, 2013

Deterioration and dead

9

Male

33

Farmer

120

CSF

Fever, headache, drowsiness

Amphotericin B for 24 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks

September 17, 2015

May 2015

AZT/3TC/EFV

Improved but died of unknown causes 1 year after discharge

10

Male

43

Unemployment

7

CSF

Limbs fatigue, headache, vomiting, urinary incontinence

Neck stiffness and a muscle power 1 out of 5 for both lower limbs

Fluconazole for 29 days (400 mg/day). Fluconazole (200 mg/day)

October 19, 2011

Oct 2007

D4T/3TC/NVP

Improved but died of unknown causes half a year after discharge