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Table 1 Clinical features, treatments and outcomes of the 10 patients of AIDS-associated T. marneffei CNS infections

From: AIDS-associated Talaromyces marneffei central nervous system infection in patients of southwestern China

PatientGenderAge, (years)JobDuration of illness (days)Test samplePresenting symptomsPresenting sign(s)Initiation treatment and maintenance therapyHospitalization timeInitial ART time and regimenOutcomes and followed up
1Male37Farmer30CSFHeadache, nausea, vomiting, irritability, unconsciousness, feverNeck stiffnessAmphotericin B for 38 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)September 1, 2009Mar 2007
AZT/3TC/NVP
Improved
2Female38Farmer60CSFDizziness, eyes distention, limbs fatigueAmphotericin B for 42 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)January 20, 2010Sep 2003
AZT/3TC/NVP
Improved
3Male36Farmer30CSF and bloodFever, right limb dyskinesiaA muscle power 4 out of 5 for right limbs, skin lesion and oral mucosal papulesAmphotericin B for 31 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)May 31, 2100Initial 28 days after hospitalization
D4T/3TC/EFV
Improved
4Male47Farmer30CSFHeadache, lower limb dyskinesia, hearing loss and diplopiaA muscle power 3 out of 5 for both lower limbsAmphotericin B for 30 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)April 16, 2013Initial 29 days after hospitalization
AZT/3TC/LPV/r
Improved
5Male46Farmer30CSFDizziness, nausea, vomiting, drowsinessA muscle power 3 out of 5 for right lower limbAmphotericin B for 34 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)January 7, 2015Jul 2010
AZT/3TC/NVP
Improved
6Male30Unemployment60CSFDizziness, lower extremity fatigueA muscle power 4 out of 5 for right lower limbAmphotericin B for 23 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)January 23, 2015Dec 2005
AZT/3TC/EFV
Improved
7Female34Worker90CSF and urineFever, headache, Left upper limb dyskinesiaA muscle power 3 out of 5 for left upper limbAmphotericin B for 40 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeks. Itraconazole (200 mg/day)May 9, 2012Initial 18 days after hospitalization AZT/3TC/EFVImproved
8Female24Farmer20CSF, blood and bone marrowFever, dizziness, weight loss, anorexia, convulsions and comaAnemia, skin lesion, oral mucosal papules and enlargement of neck lymph nodeFluconazole for 6 days (400 mg/day)March 7, 2013Deterioration and dead
9Male33Farmer120CSFFever, headache, drowsinessAmphotericin B for 24 days (0.5 mg/kg/day) followed by oral itraconazole (400 mg/day) for 10 weeksSeptember 17, 2015May 2015
AZT/3TC/EFV
Improved but died of unknown causes 1 year after discharge
10Male43Unemployment7CSFLimbs fatigue, headache, vomiting, urinary incontinenceNeck stiffness and a muscle power 1 out of 5 for both lower limbsFluconazole for 29 days (400 mg/day). Fluconazole (200 mg/day)October 19, 2011Oct 2007
D4T/3TC/NVP
Improved but died of unknown causes half a year after discharge