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Research priorities for rehabilitation and aging with HIV: a framework from the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC)

AIDS Research and Therapy volume 17, Article number: 21 (2020) Cite this article

Abstract

Background

People living with HIV are living longer, and can experience physical, mental and social health challenges associated with aging and multimorbidity. Rehabilitation is well positioned to address disability and maximize healthy aging. An international collaborative network, called the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC), works to guide this emerging field. In this article, we report findings from CIHRRC’s aim to identify emerging research priorities in HIV, aging and rehabilitation from the perspectives of people living with HIV, clinicians, researchers, representatives from community organizations and policy stakeholders.

Methods

We conducted a multi-stakeholder multi-method international consultation with people living with HIV, researchers, clinicians and representatives of community-based organizations to identify research priorities in HIV, aging and rehabilitation. Stakeholders identified research priorities during a one-day International Forum comprised of presentations and facilitated discussion. We collated and analyzed data using content analytical techniques, resulting in a framework of research priorities.

Results

Sixty-nine stakeholders from countries including Canada (n = 62; 90%), the United Kingdom (n = 5; 7%), United States (n = 1; 1%) and Australia (n = 1; 1%) attended the International Forum on HIV, Aging and Rehabilitation Research. Stakeholders represented community-based organizations (n = 20; 29%), academic institutions (n = 18; 26%), community or institutional healthcare organizations (n = 11; 16%), research or knowledge production organizations (n = 10; 14%), and organizations representing government or industry (n = 10; 14%). The Framework of Research Priorities in HIV, Aging and Rehabilitation includes seven research priorities: (1) nature, extent and impact of disability, concurrent health conditions and chronic inflammation with HIV; (2) prevalence, severity and impact of frailty; (3) community and social participation aging with HIV; (4) strategies for chronic disease management and healthy aging with HIV; (5) facilitators and barriers to access and engagement in, rehabilitation; (6) effectiveness of rehabilitation interventions for healthy aging with HIV; and (7) advancing development and use of patient reported outcome measures in HIV and aging. The Framework highlights methodological considerations to approach the priorities and the importance of knowledge translation and exchange to apply research knowledge into practice, programs and policy.

Conclusions

These priorities offer a foundation for collaboration among international and multidisciplinary teams to advance the field of HIV, aging and rehabilitation in order to promote healthy aging with HIV.

Background

With universal access to effective and tolerable antiretroviral therapy, people living with HIV are living longer [1,2,3]. They are also presenting with new clinical and social challenges associated with aging [4]. In high income countries, the proportion of people living with HIV who are 50 years of age or older increased from 15% in 2000 to 33% in 2016, with a similar trend in low and middle income countries [5, 6]. As people living with HIV age, the rising prevalence of multimorbidity including cardiovascular disease, diabetes, bone and joint disorders, neurocognitive disorders, and more recently frailty, further add to the complexity of health challenges or disability, and increased health care needs, over the life course [7,8,9,10,11,12,13,14,15,16]. Adults aging with HIV can also face additional challenges of ageism, stigma, mental health challenges, income insecurity, and lack of social support, which may intersect and further compound issues of aging with HIV [17,18,19,20,21]. These health challenges may be conceptualized as ‘disability’, broadly defined as any physical, cognitive, mental and emotional and social health challenges that can be experienced as episodic in nature with periods of fluctuating health [22]. It is critical for researchers, clinicians and policy makers to understand the changing needs of people aging with HIV, to better address disability and to incorporate the role for rehabilitation [23, 24].

In an era where more people are living longer with HIV, it is important to approach health related well-being from the perspective of person-centered care, which is inclusive of rehabilitation. In 2015, the World Health Organization revised the definition of ‘healthy aging’ to “the process of redeveloping and maintaining functional ability that enables well-being in older age” recognizing the interaction between personal and environmental factors that influence health [25]. This definition moves away from the previously used term ‘successful aging’ and acknowledges the presence of chronic disease and resultant disability while focusing on maximizing one’s function and ability within their life experience [26]. However, interventions to maximize healthy aging and how to measure their impact remains less clear [25].

The Joint United Nations Programme on HIV/AIDS (UNAIDS) established a global target of “90-90-90” whereby 90% of all people living with HIV in a community or country will be aware of their HIV status, 90% of those aware will have initiated treatment, and 90% of those on treatment will achieve viral suppression [27]. Despite achievements in viral suppression, disability, such as fatigue, mental health challenges, and financial insecurity persist. People living with HIV report lower health-related quality of life compared to the general population [28]. Lazarus and colleagues (2016) proposed a fourth “90”, meaning that 90% of those with undetectable viral load should report good health-related quality of life [29]. This requires an integrated person-centered approach to care for people living with HIV that goes beyond viral suppression to consider multimorbidity and self-perceived quality of life [29]. In 2019, the UNAIDS subsequently adopted mental well-being as a fourth “90” illustrating the importance of taking into account the broader health domains aging with HIV. This demonstrated a shift towards the importance of considering mental health, and personal and environmental factors that influence well-being aging with HIV [30]. This shift was further emphasized by the recent Lancet HIV special series, launched on World AIDS Day 2019, focused on ‘HIV Outcomes Beyond Viral Suppression’ for living well with HIV [31].

Rehabilitation is well positioned to address the fourth “90”, as it involves the dynamic process involving prevention or treatment activities and services that address symptoms, functional limitations and social participation restrictions [23]. As people age with HIV and experience multimorbidity, the need for rehabilitation will increase as traditional rehabilitation services such as physical therapy (or physiotherapy) and occupational therapy can help to address physical, cognitive and mental health challenges, such as fatigue and difficulty with mobility and daily activities; enhance mental health; facilitate return to employment; and improve social participation [32,33,34,35,36,37,38,39]. Nevertheless, the field of HIV and aging is still emerging. Few people living with HIV access formal rehabilitation services [40]. While systematic review evidence demonstrates the cost-effectiveness of rehabilitation in preventing morbidity and mortality in chronic conditions, such as neurological, musculoskeletal, and cardiovascular disease [41,42,43,44,45,46], rehabilitation evidence specific to aging with HIV is still evolving [24].

Forming partnerships and exchanging knowledge with other countries where individuals experience similar challenges related to HIV and aging is essential to address research priorities in this emerging field. In 2009, we formed a Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC), a network of researchers, clinicians, people living with HIV, representatives from community organizations and policy stakeholders with an aim to translate knowledge and identify emerging priorities in HIV and rehabilitation research [47]. In 2013, members of this collaborative convened to develop research priorities in HIV, disability and rehabilitation that included: episodic health and disability; aging with HIV across the life span; concurrent health conditions; access to rehabilitation and models of rehabilitation service provision; effectiveness of rehabilitation interventions; and enhancing outcome measurement in HIV and rehabilitation research [48]. While these priorities provided a foundation from which to direct research and clinical efforts, they do not consider more recent and emerging rehabilitation issues specific to aging with HIV. As more individuals age with HIV and experience disability with complex multimorbidity, it is critical to consider a coordinated research response from the rehabilitation field to address disability, promote health and well-being and address social needs of people aging with HIV. Our aim was to identify research priorities in HIV, aging and rehabilitation from the perspectives of people living with HIV, clinicians, researchers, representatives from community organizations and policy stakeholders.

Methods

We conducted a multi-stakeholder international consultation with people living with HIV, researchers, clinicians and representatives of community-based organizations. Stakeholders convened for a one-day International Forum on HIV and Rehabilitation Research in Winnipeg, Manitoba, Canada held in collaboration with the Canadian Association for HIV and Research (CAHR) [49] and Realize, a national HIV organization focused on advancing research, policy and practice for people living with HIV and other episodic conditions [50]. The objectives of the Forum were to: (1) facilitate knowledge transfer and exchange on HIV, aging and rehabilitation research, clinical practice, and service delivery; (2) establish new research and clinical partnerships; (3) foster mentorship and training in HIV, aging and rehabilitation research; and (4) identify emerging priorities in HIV, aging and rehabilitation [51]. Our focus in this report is on the research priorities that emerged from this consultation. We reviewed the need for ethics approval with the University of Toronto, HIV/AIDS Research Ethics Board who confirmed that given the consultative nature of the Forum, this work did not require ethics approval.

We invited people living with HIV, clinicians, academics, representatives from community-based organizations, community members, and all members of the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC) with interest and expertise in aging, HIV and rehabilitation. We promoted the Forum through email and website communications to members of Realize, CIHRRC, the Ontario HIV Treatment Network (OHTN) and Canadian Association for HIV Research (CAHR).

Nineteen invited speakers from Canada, the United Kingdom and United States presented on research and program evaluation related to HIV, aging and rehabilitation. The Forum included two Research Evidence Panel Sessions comprised of 11 presentations and one Plenary Panel Session with small and large group facilitated discussions integrated throughout. The first Research Evidence Panel Session was entitled: “Successful Aging with HIV and Multi-Morbidity” and the second Research Evidence Panel Session was entitled: “Rehabilitation Interventions and Strategies for Older Adults Living with HIV”. The Plenary Panel Session focused on strategies to bridge the gap between research and real world clinical and community practice and to identify research priorities in HIV, aging and rehabilitation. The Forum speakers’ presentation slides and videos are accessible here: http://cihrrc.hivandrehab.ca/2016-forum.php.

Data pertaining to stakeholder perspectives on research priorities were collected using the following five strategies:

  • Prior to the Forum participants were asked to submit responses to the following questions, ‘In your opinion, what are 2 new and emerging issues in the field of HIV, aging and rehabilitation?’, and ‘In your opinion, what are 2–3 key research priorities in the area of HIV, aging and rehabilitation that are essential for moving the field forward?’ [strategy 1].

  • During the Forum, participants were encouraged to document their ideas related to emerging research priorities using notepads [strategy 2], and three graduate student rapporteurs documented discussion during presentations and scheduled group discussion [strategy 3].

  • At the end of the Forum, participants were asked to complete an evaluation form that included the following questions related to research priorities: ‘What are the three most important “take-home messages” that you heard at the Forum?’, and ‘Are there topics or issues that were raised today that you would like to see covered in future Forums, workshops or webinars?’ [strategy 4]

  • After the Forum, we met with student rapporteurs to consolidate key points related to research priorities on HIV, aging and rehabilitation that emerged from the Forum [strategy 5].

We used the collective responses, discussion, and feedback derived from these sources as the foundation for identifying the research priorities. We collated and analyzed the data using conventional content analytical techniques [52]. The primary author (KKO) reviewed all sources of data, coded and clustered codes into categories to represent research priorities in HIV, aging and rehabilitation. We used Microsoft Excel to organize the data and codes [53]. Members of a Core Team (KKO, FIC, PS, and a representative from Realize, Canada), met to review the data, identify research priority areas derived from the coding process, cluster the priority areas into broader content areas, and organize them into a draft Framework of Research Priorities. The Framework was circulated twice for review and refinement by members of the authorship team.

Results

Participant stakeholder characteristics

Sixty-nine stakeholders from Canada (90%; n = 62), the United Kingdom (7%; n = 5), United States (1%; n = 1) and Australia (1%; n = 1) with expertise in the field of HIV, aging with HIV and rehabilitation attended the Forum. Most were researchers (22%; n = 15), followed by educators (17%; n = 12), service providers (13%; n = 9), community members, people living with HIV and other chronic illnesses (6%; n = 4), graduate students (13%; n = 9), clinicians (6%; n = 4), and other stakeholders including coordinators and program managers (23%; n = 16). Researchers, clinicians and educators were primarily rehabilitation professionals (physiotherapists or occupational therapists), physicians (geriatrics, rehabilitation medicine, infectious diseases, psychiatry), and nursing. Stakeholders worked in community-based organizations (29%; n = 20), academic institutions (26%; n = 18), community or institutional healthcare organizations (16%; n = 11), research or knowledge production organizations (14%; n = 10), and organizations representing government or industry (14%; n = 10). Of the 69 stakeholders, 16 (23%) were speakers at the Forum; of these 13 (81%) were from Canada, two (13%) from the United Kingdom, and one (6%) from the United States.

Framework of Research Priorities in HIV, Aging and Rehabilitation

The “Framework of Research Priorities in HIV, Aging and Rehabilitation” reflects how rehabilitation interventions have a critical role in addressing the complex health and social challenges experienced by individuals as they age with HIV and multimorbidity. It highlights priorities for HIV, aging and rehabilitation research, and offers a scaffold for collaboration among multidisciplinary teams to generate evidence on healthy aging with HIV. The Framework is comprised of seven research priorities: (1) examining the nature, extent and impact of disability resulting from concurrent health conditions and chronic inflammation aging with HIV; (2) examining the prevalence, severity and impact of frailty; (3) exploring community and social participation aging with HIV; (4) identifying strategies for chronic disease management and healthy aging with HIV; (5) examining facilitators and barriers to access and engagement in, rehabilitation; (6) determining the effectiveness of rehabilitation interventions to support healthy aging with HIV; and (7) advancing the development, measurement property assessment (validity, reliability, responsiveness), and use of screening tools and patient reported outcome measures (PROMs) in HIV and aging research (Fig. 1). These priorities were clustered into three broader content areas: (A) Multimorbidity, Episodic Health and Disability Aging with HIV; (B) Rehabilitation Interventions for Healthy Aging across the Lifespan; and (C) Outcome Measurement in HIV and Aging Research. The Framework includes methodological considerations identified from the consultation through which to approach the priorities, and highlights the importance of knowledge translation and exchange to mobilize research evidence into future practice, programs and policy (Fig. 1). The Framework is intended to inform future HIV, aging and rehabilitation research and to serve as a knowledge transfer and exchange tool that may be used by researchers, clinicians, students, people living with HIV and the broader HIV community. The priorities are presented below in no particular order of importance.

Fig. 1
figure 1

Framework of Research Priorities in HIV, Aging and Rehabilitation

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Content area 1: multimorbidity, episodic health and disability

Stakeholders highlighted the importance of multimorbidity prevention and health promotion as people age with HIV. This includes people living with HIV at all ages, and particularly older adults experiencing challenges due to the impact of years living with HIV, side effects of antiretroviral medications, and adults diagnosed with HIV in older adulthood.

Research priority 1: nature, extent and impact of disability associated with concurrent health conditions and chronic inflammation among people aging with HIV

Research should seek to understand the prevalence, severity and impact of disability [22], including experiences of people aging with HIV and the added complexities that come from living with concurrent health conditions. Mental and cognitive health challenges such as depression, anxiety, and HIV-associated neurocognitive disorder (HAND) should also be considered. Concurrent health conditions experienced by people aging with HIV can be episodic in nature whereby the duration and intensity of illness and its resulting disability are unknown. Uncertainty was a specific domain of disability highlighted as a priority for people aging with HIV as a consequence of episodic illness, affecting stable employment and housing, and imposing restrictions on social engagement.

Stakeholders also highlighted the importance of exploring disability associated with inflammation and aging with HIV. Inflammation may increase risk for metabolic, bone, or cardiovascular health conditions [54,55,56]. Researchers should examine the association between chronic inflammation and disability among individuals aging with HIV; however, to our knowledge, there is a dearth of research considering the association between the inflammatory processes and daily physical and cognitive function with HIV. Better understanding the effects of chronic inflammation on disability aging with HIV can assist health care providers to develop targeted interventions aimed to manage disability over time.

Research priority 2: frailty

Frailty is defined as an age-related syndrome to characterize a loss of reserves (energy, physical ability, cognition, health) that can yield to increased vulnerability and susceptibility to adverse clinical outcomes, such as hospitalization and disability [57, 58]. Stakeholders highlighted frailty as an emerging priority for adults aging with HIV. Research should examine the prevalence, severity and impact of frailty among adults aging with HIV, and the association between frailty and domains of disability (physical, mental, social and uncertainty domains) to develop strategies to prevent or minimize frailty among people living with HIV.

Research priority 3: community and social participation aging with HIV

Stakeholders indicated how those diagnosed prior to the era of combination antiretroviral therapy might now be transitioning into retirement age with a history of unemployment and limited income support. This can result in unstable housing, and added stress and anxiety, subsequently limiting engagement with others in social settings and resulting in social isolation [59, 60]. In addition, stigma associated with HIV and aging emerged as an important contextual factor that may interact with gender, employment status, and ethnocultural background, further exacerbating challenges to community and social participation. Research should consider the experiences of people living with HIV as they transition into older age, and how differences in timing of HIV diagnosis in the pre or post combination antiretroviral therapy era can result in differences in community and social participation. Further research should seek to better understand the unique housing and social engagement needs of adults aging with HIV and multimorbidity. Researchers should collaborate with policy stakeholders and housing service providers to explore creative evidence-informed solutions to increase accessibility and affordable housing for adults aging with HIV.

Content area 2: rehabilitation interventions for healthy aging across the lifespan

Stakeholders emphasized the importance of rehabilitation interventions to address and prevent disability associated with aging with HIV and multimorbidity. Three research priorities were identified in this content area.

Research priority 4: strategies for chronic disease management and healthy aging with HIV

Stakeholders highlighted the importance of identifying factors that facilitate healthy aging with HIV. This requires recognizing that goals, values, preferences and expectations may differ depending on age and length of time living with HIV. Self-management can be defined as “an individual’s ability to manage the symptoms, treatment, physical and psychosocial consequences living with a chronic condition” [61]. In the Forum discussion, self-management strategies emerged as a key component of healthy aging along with resilience, characterized as the ability to recover from longstanding episodic and chronic challenges living with HIV. Rehabilitation interventions that address the multidimensional and episodic nature of disability can reinforce and promote self-management skills for disability associated with HIV and aging [23, 62, 63]. Goal setting, promoting independence, enhancing recovery, recognizing progress, and valuing reassurance from others are key aspects of self-management support, and integral to developing self-efficacy through the rehabilitation process among people with chronic disease [64]. However, to date there is a paucity of research that examines models of health care that integrate these approaches specifically for older adults living with HIV. Future research should examine the impact of adopting living strategies, including resilience and self-management in the context of chronic disease management to promote healthy aging with HIV.

Research priority 5: examining facilitators and barriers to access and engagement in rehabilitation for people aging with HIV

The role and importance of rehabilitation for healthy aging with HIV emerged from the consultation; however, stakeholders highlighted barriers that exist in accessing formalized services. Navigating the healthcare system for people living with HIV can be challenging with other competing life priorities (e.g., food, housing). Developing coordinated access to rehabilitation services through partnerships between healthcare providers and community-based organizations are integral for helping to navigate the system and identify where people aging with HIV may access services. For those with access to rehabilitation services, stakeholders highlighted the need to examine the nature and extent to which people living with HIV engage in rehabilitation and self-management interventions, such as physical activity and exercise.

Stakeholders further highlighted the need for evaluating the effect of educational interventions and strategies aimed to increase knowledge about the role of rehabilitation among current and future health professionals, recreation and community providers, and people aging with HIV. At Realize, connections are facilitated between HIV organizations and universities through role-emerging placements for physiotherapy and occupational therapy students [65]. Members of this team have developed educational modules for people living with HIV and rehabilitation professionals to enhance knowledge, skills and attitudes working in HIV care [66, 67]. Future research may examine the impact of new models of rehabilitation service delivery including interdisciplinary educational interventions on their ability to enhance knowledge and access to rehabilitation interventions for people living with HIV.

Research priority 6: determining the effectiveness of rehabilitation interventions to support healthy aging with HIV

Stakeholders identified the need to evaluate the effect and translation of rehabilitation interventions to address the intersecting physical, social and mental health domains of disability experienced by adults aging with HIV. Rehabilitation interventions under evaluation should take into account the social determinants of health and diversity of populations of adults aging with HIV related to gender, social roles, age, duration of time living with HIV, literacy, multimorbidity, culture, race, geographic location and access to health services. It is important to understand the complexity of health issues faced by people living with HIV when evaluating rehabilitation interventions and models of rehabilitation service delivery [32, 33]. People aging with HIV should be actively involved in the planning of rehabilitation interventions to ensure approaches align with person-centered goals, values, preferences and diversity of the target audience. Physiotherapy is important for improving locomotor performance, strength, health related quality of life, and flexibility [37]. As the need for rehabilitation emerges and community health centers and clinics integrate physiotherapists and occupational therapists as members of the interdisciplinary team, there is an opportunity to maximize timely, appropriate and effective implementation and evaluation of rehabilitation services and interventions with the potential to optimize health outcomes for people living with HIV. Finally, as the role for rehabilitation continues to grow in the context of HIV and aging, stakeholders highlighted the importance of examining the need for evaluating the role of technology such as wireless physical activity monitors, online applications, social media, and online tele-coaching in measuring and augmenting engagement in rehabilitation.

Content area 3: outcome measurement in HIV and aging research

In addressing priorities related to episodic disability and the effect of rehabilitation interventions and education, stakeholders highlighted the need to advance outcome measurement in HIV and aging research, specifically developing and assessing tools for their ability to accurately and reliably measure indicators of health and disability for adults aging with HIV. We highlight a few specific constructs highlighted as important to HIV, rehabilitation and aging.

Research priority 7: advancing the development, property assessment, and use of screening tools and Patient Reported Outcome Measures (PROMs)

Stakeholders identified the need to develop and advance HIV-specific person-centred screening tools and outcome measures to facilitate assessment and evaluate the effectiveness of interventions. Accurately and reliably screening for frailty was highlighted as a priority among adults aging with HIV to pre-emptively target strategies to prevent further progression. Measurements of frailty such as the Frailty Phenotype [57], Index [68], or Scale [69] exist; however with no gold standard assessment for HIV-associated frailty, there is a need to identify and validate which tools capture the presence and severity of frailty and can detect changes in frailty when it occurs among adults living with HIV. Stakeholders also emphasized the need to enhance patient-centeredness in research for older adults living with HIV by using Patient Reported Outcome Measures (PROMs) to evaluate disability experienced aging with HIV, facilitate communication between patients and providers, and examine the effectiveness of rehabilitation interventions.

Methodological considerations

Our consultation process was not limited to research content areas alone. Methodological considerations for addressing these seven research priorities also emerged from the consultation. Stakeholders recommended that researchers consider barriers to engaging in research, such as stigma, and the need for culturally safe, anti-oppressive and age-sensitive interventions to better engage adults aging with HIV. For example, strategies for better engaging Indigenous adults aging with HIV in colonized countries such as Canada, new migrants living with HIV, individuals in rural geographical regions as well as those who may be experiencing stigma and fear of disclosure. Community-engaged approaches, involving people living with HIV in all aspects of the rehabilitation research is critical for ensuring the research is meaningful and relevant to the community [70,71,72,73]. Strategies such as the Strategy for Patient Oriented Research (SPOR) [74], and incorporating culturally appropriate, age-sensitive, valid, and reliable PROMs, were also recommended to yield better outcomes. Given the barriers to accessing rehabilitation in environments of fiscal restraint, researchers should include cost effectiveness outcomes in research evaluating rehabilitation interventions with older adults living with HIV. Other methodological considerations include considering the use of HIV-negative comparison groups, comprised of people matched in terms of age, gender and other important characteristics, to sample populations of people aging with HIV.

Knowledge translation and exchange

The final component of the Framework includes recommendations for translating research into practice, programs, and policy to enhance access to timely and effective rehabilitation interventions for people living with HIV. Stakeholders discussed the importance of linking research with practice, highlighting the necessity for research to be driven by the needs of communities of practice, and to ensure that research evidence is translated in a way to meaningfully impact programs and policy. Developing evidence-informed recommendations can facilitate translation of research into practice and optimize health outcomes for people aging with HIV. Members of our team established recommendations for rehabilitation among older adults with HIV, drawing on high-level evidence in other chronic conditions [24]. As new evidence emerges specific to rehabilitation interventions among people aging with HIV and multimorbidity, we will be able to revisit and enhance such recommendations incorporating HIV-specific literature. Strategies are also needed to facilitate the application of research knowledge generated from these priority areas. Mechanisms such as International Forums on HIV and Rehabilitation Research can facilitate translation of research evidence on HIV and rehabilitation in partnership with other annual conferences and providing open access to presentations and research findings [75] (http://cihrrc.hivandrehab.ca/forums.php).

Discussion

The Framework of Research Priorities in HIV, Aging and Rehabilitation emerged from the perspectives of an international group of researchers, clinicians, people living with HIV, representatives from community-based organizations, funders and policy stakeholders in the field of HIV, aging, and rehabilitation. While the priorities are in no particular order, they outline a multi-directional path to examine disability and rehabilitation interventions, evaluating effectiveness with the use of PROMs. These priorities should not be addressed in isolation, but rather considered as overlapping constructs, such as the impact of episodic disability, and how rehabilitation interventions work in real world community or clinic-based settings. The Framework reflects research priorities specific to aging in the HIV and rehabilitation field, building on previous research priorities broadly established for HIV and rehabilitation [48]. As an international collaborative focused on HIV and rehabilitation research, we discuss how the field is striving to address these priority areas, and how this work provides a guide for further strengthening meaningful, rigorous and collaborative evidence on healthy aging in HIV and rehabilitation.

Members of our collaborative led foundational work examining reasons for referral, and effectiveness of rehabilitation interventions, specifically the role and impact of physiotherapy-led models of care for adults living with HIV in the United Kingdom [37], United States [62], Canada [32, 33] and South Africa [76,77,78,79]. Better understanding the biological, social and behavioural factors that interact with HIV and aging can help to identify effective rehabilitation interventions that promote well-being in this growing population [80]. The Episodic Disability Framework was developed from the perspectives of adults living with HIV, commonly used as a foundation for understanding how multimorbidity may interact with and influence health challenges over time aging with HIV [22, 81]. Solomon and colleagues used qualitative approaches to explore experiences of episodic disability over time, establishing phenotypes of episodic disability as a foundation in which to approach rehabilitation treatment for people aging with HIV and sometimes fluctuating multimorbidity [82]. While progress has been made towards understanding disability with HIV and aging, the majority of this work has been cross-sectional in nature. Future work to examine the types of disability domains that are experienced as episodic over time, and their magnitude of fluctuating severity will help to identify areas for providers to target interventions to mitigate or prevent episodes of disability among individuals aging with HIV.

Uncertainty and worrying about planning for the future is a key component of the Episodic Disability Framework [22] and emerged from our consultation as a priority for HIV, aging and rehabilitation research. Our earlier work demonstrated that uncertainty is a key feature of disability and strongly predicts mental health and social inclusion challenges as an individual ages with HIV [83, 84]. Older adults, representing the first cohort of people living with HIV to grow old, expressed concerns as to whether their health providers have age-related knowledge and skills to care for them as they age [85, 86]. Financial uncertainty is a concern, particularly for individuals diagnosed with HIV earlier in age who may have left the work force with no expectation of living into older adulthood, compared to those diagnosed later in life with years of pension contributions leading up to retirement [83]. For those working, employment not only provides financial benefits, but also a source of structure, social support, role-identity and meaning [87, 88]. As the fourth “90” of the UNAIDS “90-90-90” global targets concentrating on mental health and well-being, rehabilitation focused on strategies to engage people aging with HIV in community and social life, and evaluating the impact of these strategies, will be critical for people transitioning into retirement and longer term care settings. Examining the prevalence and impact of uncertainty, and determining how rehabilitation interventions can address worrying about the future and mental-emotional health challenges will be critical as adults age with HIV.

Loneliness and social isolation are key factors associated with depression, functional impairment and poorer quality of life among adults with HIV [89]. However, resilience (positive adaptation of past or present adversity) has been linked with healthy aging among adults living with HIV [90]; those who demonstrated high levels of self-acceptance and optimism, and implemented positive self-management strategies experienced health aging with HIV [91]. Positive self-management can result in better physical and emotional health, and health knowledge and behaviour among people living with HIV [92]. Members of the CIHRRC collaborative have made considerable strides examining the role of self-management interventions specific to people living with HIV [92]. Given the barriers to accessing formalized rehabilitation services, strategies promoting resilience and self-management have an increasing role for empowering individuals to maximize their own health and well-being while aging with HIV [85, 93]. For instance, exercise is a widely accepted rehabilitation intervention to improve physical and mental health outcomes among adults living with HIV [94,95,96,97] and implementation science approaches are underway to examine the effectiveness of community-based exercise for adults with HIV in Canada [98] and South Africa [77]. Evidence examining the effectiveness of yoga interventions also is emerging in the context of HIV [38, 99]; however, data comparing level of engagement in and response to these physical activity interventions among older versus younger adults living is limited. Ultimately, rehabilitation professionals should be included in multidisciplinary research teams in order to ensure safe and effective exercise prescription, and energy conservation and environmental modifications to prevent injury and sustain social participation to older adults with HIV, disability, frailty, and complex multimorbidity [58].

As more individuals age with HIV, geriatric syndromes such as frailty, fall risk, and declining physical function are increasingly important to measure and address within rehabilitation for adults aging with HIV [7, 100, 101]. The Fried phenotype [57] and Rockwood criteria [68, 102] have been commonly used in the HIV context [100] and new clinical guidelines outline ways to measure and treat frailty with people living with HIV [103]. Nevertheless, consideration of frailty in HIV and rehabilitation is still evolving. Researchers should more consistently consider frailty as an outcome of interest in rehabilitation research, better understand how to screen for pre-frailty, and tailor appropriate rehabilitation interventions to treat and prevent further progression.

Using PROMs in HIV care can foster a person-centred approach promoting patient involvement in decision-making, and improving communication and relationships between patients and professionals, which can encourage appropriate referrals, and improve treatment adherence [104]. Among 117 HIV-specific PROMs identified in a systematic review, most measured health-related quality of life (20%) with fewer capturing self-management (7%), stigma (7%), social support (3%) or disability (1%), all of which are important constructs to those aging with HIV [105]. Furthermore, approximately half of these measures were over 20 years old, and might not reflect the current health issues and contextual factors faced by adults aging with HIV. The development, validation and use of culturally sensitive, age- and contextually-appropriate measures that capture important constructs to adults aging with HIV diagnosed at different eras of antiretroviral therapy is needed to determine the effectiveness of rehabilitation interventions [104]. Members of our team developed the first known HIV-specific disability questionnaire, the HIV Disability Questionnaire (HDQ). This multidimensional tool has been validated for use among people living with HIV in Canada, Ireland, the United Kingdom and United States [106,107,108]. Current work is underway to develop and validate a short-form version of this PROM to enhance utility in the clinical setting. Communication among collaborative networks, such as CIHRRC may help to identify a common set of PROMs that may be used in research and practice in order to facilitate international cross-cultural comparisons of health outcomes and strengthen evidence in HIV, disability, and rehabilitation interventions.

These research priorities were developed from the perspectives of a multidisciplinary group of stakeholders with longstanding clinical, research and lived experiential expertise in HIV, aging and rehabilitation. Our community-engaged approaches involving people living with HIV in the consultation and development of the Framework was a strength given evidence suggests priorities can differ between health providers and patients living with HIV [109]. While we did not collect information on the age of stakeholders, older adults living with HIV were part of this consultation. We did not use a formal Delphi or nominal group technique to identify the priorities [110]. While our consultation was international in nature, stakeholders represented high income countries. The lack of representation of stakeholders from low to middle-income countries conducting work in HIV, aging and disability is a limitation of this work [15, 16, 76, 77]. Since this consultation, our international collaborative has grown to include partnerships with rehabilitation professionals in lower income countries such as South Africa, who have observed similar disability and rehabilitation issues in the context of HIV [79, 111]. While these priorities are specifically developed through a rehabilitation lens, addressing them will require collaborative and interprofessional and community-engaged approaches involving HIV, primary and geriatric care teams, social work, and psychology, in addition to rehabilitation to move the field forward. Members of our team are engaged in community-based and engaged methodological approaches and knowledge translation considerations in addressing these research priorities. For instance, Ibanez-Carrasco and colleagues challenged traditional methodology by working with peer researchers living with HIV and neurocognitive disorders in a Canadian study examining the impact of living with HIV associated neurocognitive disorders [112]. Finally, we acknowledge the field is continually changing and new priorities will emerge as the course of HIV evolves and the role for rehabilitation in the context of HIV continues to grow. Through mechanisms such as CIHRRC, we can facilitate new partnerships and translation of research evidence on HIV and rehabilitation providing open access to presentations and research findings and ongoing dialogue about new and emerging priorities in the field [75].

Conclusion

As people live longer and age with HIV and the need for rehabilitation continues to rise, research addressing disability and effectiveness of rehabilitation interventions is critical for moving the field forward. We propose a Framework of Research Priorities in HIV, Aging and Rehabilitation comprised of seven priority areas in which researchers, clinicians, community members may build on foundational work to date to guide rigorous and meaningful evidence to inform the field. Examining strategies for chronic disease self-management, resilience effectiveness of rehabilitation intervention and advancing PROMs with adults living with HIV will be critical moving forward. These priorities outline a future plan for HIV, aging and rehabilitation research that will help increase our knowledge to enhance practice, programming and policy for people aging with HIV.

Availability of data and materials

The data used and/or analysed during the current study are available from the corresponding author on reasonable request.

Abbreviations

CIHRRC:

Canada-International HIV and Rehabilitation Research Collaborative

PROMs:

Patient-reported outcome measures

UNAIDS:

United Nations Programme on HIV/AIDS

References

  1. Collaboration Antiretroviral Therapy Cohort. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008;372(9635):293–9 (Epub 2008/07/29).

    Article  Google Scholar 

  2. Collaboration Antiretroviral Therapy Cohort. Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies. The lancet HIV. 2017;4(8):e349–56.

    Article  Google Scholar 

  3. Johnson LF, Mossong J, Dorrington RE, Schomaker M, Hoffmann CJ, Keiser O, et al. Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies. PLoS Med. 2013;10(4):e1001418 (Epub 2013/04/16).

    PubMed  PubMed Central  Article  Google Scholar 

  4. Allavena C, Hanf M, Rey D, Duvivier C, BaniSadr F, Poizot-Martin I, et al. Antiretroviral exposure and comorbidities in an aging HIV-infected population: the challenge of geriatric patients. PLoS ONE. 2018;13(9):e0203895 (Epub 2018/09/22).

    PubMed  PubMed Central  Article  CAS  Google Scholar 

  5. Autenrieth CS, Beck EJ, Stelzle D, Mallouris C, Mahy M, Ghys P. Global and regional trends of people living with HIV aged 50 and over: estimates and projections for 2000–2020. PLoS ONE. 2018;13(11):e0207005 (Epub 2018/11/30.).

    PubMed  PubMed Central  Article  CAS  Google Scholar 

  6. Emlet CA, Fredriksen-Goldsen KI, Kim HJ, Jung H. Accounting for HIV health disparities: risk and protective factors among older gay and bisexual Men. J Aging Health. 2019:898264319848570. Epub 2019/05/14.

  7. Bloch M. Frailty in people living with HIV. AIDS Res Ther. 2018;15(1):19 (Epub 2018/11/18).

    PubMed  PubMed Central  Article  Google Scholar 

  8. Vance DE, Mugavero M, Willig J, Raper JL, Saag MS. Aging with HIV: a cross-sectional study of comorbidity prevalence and clinical characteristics across decades of life. J Assoc Nurses AIDS Care. 2011;22(1):17–25.

    PubMed  Article  Google Scholar 

  9. Guaraldi G, Malagoli A, Calcagno A, Mussi C, Celesia BM, Carli F, et al. The increasing burden and complexity of multi-morbidity and polypharmacy in geriatric HIV patients: a cross sectional study of people aged 65–74 years and more than 75 years. BMC Geriatr. 2018;18(1):99 (Epub 2018/04/22).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  10. Heaton RK, Clifford DB, Franklin DR Jr, Woods SP, Ake C, Vaida F, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology. 2011;75(23):2087–96 (Epub 2010/12/08).

    Article  Google Scholar 

  11. Kendall CE, Wong J, Taljaard M, Glazier RH, Hogg W, Younger J, et al. A cross-sectional, population-based study measuring comorbidity among people living with HIV in Ontario. BMC public health. 2014;14(1):161 (Epub 2014/02/15).

    PubMed  PubMed Central  Article  Google Scholar 

  12. Hasse B, Ledergerber B, Furrer H, Battegay M, Hirschel B, Cavassini M, et al. Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study. Clin Infect Dis. 2011;53(11):1130–9 (Epub 2011/10/15).

    PubMed  Article  Google Scholar 

  13. Guaraldi G, Orlando G, Zona S, Menozzi M, Carli F, Garlassi E, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis. 2011;53(11):1120–6 (Epub 2011/10/15).

    PubMed  Article  Google Scholar 

  14. Sabin CA, Reiss P. Epidemiology of ageing with HIV: what can we learn from cohorts? Aids. 2017;31(Suppl 2):S121–8 (Epub 2017/05/05).

    PubMed  Article  Google Scholar 

  15. Myezwa H, Hanass-Hancock J, Ajidahun AT, Carpenter B. Disability and health outcomes—from a cohort of people on long-term anti-retroviral therapy. SAHARA J. 2018;15(1):50–9.

    PubMed  PubMed Central  Article  Google Scholar 

  16. Hanass-Hancock J, Myezwa H, Carpenter B. Disability and living with HIV: baseline from a cohort of people on long term ART in South Africa. PLoS ONE. 2015;10(12):e0143936.

    PubMed  PubMed Central  Article  CAS  Google Scholar 

  17. Havlik RJ, Brennan M, Karpiak SE. Comorbidities and depression in older adults with HIV. Sexual Health. 2011;8(4):551–9 (Epub 2011/12/01).

    PubMed  Article  Google Scholar 

  18. Shippy RA, Karpiak SE. The aging HIV/AIDS population: fragile social networks. Aging Ment Health. 2005;9(3):246–54.

    CAS  PubMed  Article  Google Scholar 

  19. Roger KS, Mignone J, Kirkland S. Social aspects of HIV/AIDS and aging: a thematic review. Can J Aging. 2013;32(3):298–306 (Epub 2013/08/15).

    PubMed  Article  Google Scholar 

  20. Siemon J, Blenkhorn L, Wilkins S, O’Brien KK, Solomon P. A grounded theory of social participation among older women living with HIV. Can J Occup Ther. 2013;80(4):241–50.

    PubMed  Article  Google Scholar 

  21. Emlet CA. “You’re awfully old to have this disease”: experiences of stigma and ageism in adults 50 years and older living with HIV/AIDS. Gerontologist. 2006;46(6):781–90 (Epub 2006/12/16).

    PubMed  Article  Google Scholar 

  22. O’Brien KK, Bayoumi AM, Strike C, Young NL, Davis AM. Exploring disability from the perspective of adults living with HIV/AIDS: development of a conceptual framework. Health Qual Life Outcomes. 2008;6:76 (Epub 2008/10/07).

    PubMed  PubMed Central  Article  Google Scholar 

  23. Worthington C, Myers T, O’Brien K, Nixon S, Cockerill R. Rehabilitation in HIV/AIDS: development of an expanded conceptual framework. AIDS Patient Care STDS. 2005;19(4):258–71.

    PubMed  Article  Google Scholar 

  24. O’Brien KK, Solomon P, Trentham B, MacLachlan D, MacDermid J, Tynan AM, et al. Evidence-informed recommendations for rehabilitation with older adults living with HIV: a knowledge synthesis. BMJ Open. 2014;4(5):e004692 (Epub 2014/05/17).

    PubMed  PubMed Central  Article  Google Scholar 

  25. Michel JP, Sadana R. “Healthy aging” concepts and measures. J Am Med Dir Assoc. 2017;18(6):460–4 (Epub 2017/05/10).

    PubMed  Article  Google Scholar 

  26. Emlet CA, Harris L, Furlotte C, Brennan DJ, Pierpaoli CM. ‘I’m happy in my life now, I’m a positive person’: approaches to successful ageing in older adults living with HIV in Ontario. Canada. Aging and Society. 2017;37(10):2128–51.

    Article  Google Scholar 

  27. Joint United Nations Programme on HIV/AIDS (UNAIDS). 90-90-90: An ambitious treatment target to help end the AIDS epidemic. Geneva: UNAIDS; 2014.

    Google Scholar 

  28. Erdbeer G, Sabranski M, Sonntag I, Stoehr A, Horst HA, Plettenberg A, et al. Everything fine so far? Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy. J Int AIDS Soc. 2014;17:19673 (Epub 2014/11/15).

    PubMed  PubMed Central  Article  Google Scholar 

  29. Lazarus JV, Safreed-Harmon K, Barton SE, Costagliola D, Dedes N, Del Amo Valero J, et al. Beyond viral suppression of HIV—the new quality of life frontier. BMC medicine. 2016;14(1):94 (Epub 2016/06/24).

    PubMed  PubMed Central  Article  Google Scholar 

  30. Webster P. UNAIDS survey aligns with so-called fourth 90 for HIV/AIDS. Lancet. 2019;393(10187):P2188.

    Article  Google Scholar 

  31. The Lancet H. Living well with HIV. The lancet HIV. 2019;6(12):e807 (Epub 2019/11/30).

    Article  Google Scholar 

  32. deBoer H, Cudd S, Andrews M, Leung E, Petrie A, Chan Carusone S, et al. Recommendations for integrating physiotherapy into an interprofessional outpatient care setting for people living with HIV: a qualitative study. BMJ Open. 2019;9(5):e026827 (Epub 2019/05/28).

    PubMed  PubMed Central  Article  Google Scholar 

  33. deBoer H, Andrews M, Cudd S, Leung E, Petrie A, Chan Carusone S, et al. Where and how does physical therapy fit? Integrating physical therapy into interprofessional HIV care. Disabil Rehabil. 2019;41(15):1768–77 (Epub 2018/03/14).

    PubMed  Article  Google Scholar 

  34. Galantino ML, McReynolds MA. Physical therapy management of HIV disease: a retrospective study. J Int Assoc Physicians AIDS Care. 1995;1(5):15–8.

    CAS  PubMed  Google Scholar 

  35. Cobbing S, Hanass-Hancock J, Deane M. Physiotherapy rehabilitation in the context of HIV and disability in KwaZulu-Natal, South Africa. Disabil Rehabil. 2014;36(20):1687–94.

    PubMed  Article  Google Scholar 

  36. Pullen SD, Chigbo NN, Nwigwe EC, Chukwuka CJ, Amah CC, Idu SC. Physiotherapy intervention as a complementary treatment for people living with HIV/AIDS. HIV AIDS. 2014;6:99–107.

    Google Scholar 

  37. Brown D, Claffey A, Harding R. Evaluation of a physiotherapy-led group rehabilitation intervention for adults living with HIV: referrals, adherence and outcomes. AIDS Care. 2016;28(12):1495–505.

    PubMed  Article  Google Scholar 

  38. Kietrys DM, Galantino ML, Cohen ET, Parrott JS, Gould-Fogerite S, O’Brien KK. Yoga for persons living with HIV-related distal sensory polyneuropathy: a case series. Rehabil Oncol. 2018;36(2):123–31.

    Article  Google Scholar 

  39. Worthington C, O’Brien K, Zack E, McKee E, Oliver B. Enhancing labour force participation for people living with HIV: a multi-perspective summary of the research evidence. AIDS Behav. 2012;16(1):231–43 (Epub 2011/06/28).

    PubMed  Article  Google Scholar 

  40. Worthington C, Myers T, O’Brien K, Nixon S, Cockerill R, Bereket T. Rehabilitation professionals and human immunodeficiency virus care: results of a national Canadian survey. Arch Phys Med Rehabil. 2008;89(1):105–13 (Epub 2008/01/01).

    PubMed  Article  Google Scholar 

  41. Burge E, Monnin D, Berchtold A, Allet L. Cost-effectiveness of physical therapy only and of usual care for various health conditions: systematic review. Phys Ther. 2016;96(6):774–86 (Epub 2015/12/19).

    PubMed  Article  Google Scholar 

  42. Turner-Stokes L, Dzingina M, Shavelle R, Bill A, Williams H, Sephton K. Estimated life-time savings in the cost of ongoing care following specialist rehabilitation for severe traumatic brain injury in the United Kingdom. J Head Trauma Rehabil. 2019;34(4):205–14 (Epub 2019/02/26).

    PubMed  PubMed Central  Article  Google Scholar 

  43. Turner-Stokes L, Bavikatte G, Williams H, Bill A, Sephton K. Cost-efficiency of specialist hyperacute in-patient rehabilitation services for medically unstable patients with complex rehabilitation needs: a prospective cohort analysis. BMJ Open. 2016;6(9):e012112 (Epub 2016/09/10).

    PubMed  PubMed Central  Article  Google Scholar 

  44. Turner-Stokes L, Williams H, Bill A, Bassett P, Sephton K. Cost-efficiency of specialist inpatient rehabilitation for working-aged adults with complex neurological disabilities: a multicentre cohort analysis of a national clinical data set. BMJ Open. 2016;6(2):e010238 (Epub 2016/02/26).

    PubMed  PubMed Central  Article  Google Scholar 

  45. Shields GE, Wells A, Doherty P, Heagerty A, Buck D, Davies LM. Cost-effectiveness of cardiac rehabilitation: a systematic review. Heart. 2018;104(17):1403–10 (Epub 2018/04/15).

    PubMed  Article  Google Scholar 

  46. Edwards K, Jones N, Newton J, Foster C, Judge A, Jackson K, et al. The cost-effectiveness of exercise-based cardiac rehabilitation: a systematic review of the characteristics and methodological quality of published literature. Health economics review. 2017;7(1):37 (Epub 2017/10/21).

    PubMed  PubMed Central  Article  Google Scholar 

  47. O’Brien KK, Solomon P, Ibáñez-Carrasco F, Chegwidden W, McDonnell E, Brown D, et al. Evolution of an International Research Collaborative in HIV and Rehabilitation: community engaged process, lessons learned, and recommendations. Prog Commun Health Partn. 2018;12(4):395–408.

    Google Scholar 

  48. O’Brien KK, Ibanez-Carrasco F, Solomon P, Harding R, Cattaneo J, Chegwidden W, et al. Advancing research and practice in HIV and rehabilitation: a framework of research priorities in HIV, disability and rehabilitation. BMC Infect Dis. 2014;14(1):3851 (Epub 2015/01/01).

    Article  Google Scholar 

  49. Canadian Association for HIV Research (CAHR). Canadian Association for HIV Research (CAHR). https://www.cahr-acrvca/. 2020.

  50. Realize. Strategic Plan 2019-2022. https://www.realizecanadaorg/wp-content/uploads/Realize-Strategic-Plan-2019-2022pdf. 2019.

  51. Canada-United Kingdom HIV and Rehabilitation Research Collaborative (CUHRRC). 3rd International Forum on HIV and Rehabilitation Research. Advancing International Partnerships to Address Key Research Priorities in HIV and Rehabilitation (Final Report): Winnipeg, Canada. 2016. http://cuhrrc.hivandrehab.ca/docs/3rd-International-Forum-Final-Report-FINAL-CIRCULATED-Sept-2-16.pdf.

  52. Hsieh HF, Shannon SE. Three approaches to qualitative content analysis. Qual Health Res. 2005;15(9):1277–88 (Epub 2005/10/06).

    PubMed  Article  Google Scholar 

  53. Microsoft Corporation. Microsoft Excel. Microsoft Corporation; 2016.

  54. Zicari S, Sessa L, Cotugno N, Ruggiero A, Morrocchi E, Concato C, et al. Immune activation, inflammation, and non-AIDS co-morbidities in HIV-infected patients under long-term ART. Viruses. 2019;11(3):200 (Epub 2019/03/02).

    CAS  PubMed Central  Article  Google Scholar 

  55. Nasi M, De Biasi S, Gibellini L, Bianchini E, Pecorini S, Bacca V, et al. Ageing and inflammation in patients with HIV infection. Clin Exp Immunol. 2017;187(1):44–52.

    CAS  PubMed  Article  Google Scholar 

  56. Deeks SG, Tracy R, Douek DC. Systemic effects of inflammation on health during chronic HIV infection. Immunity. 2013;39(4):633–45 (Epub 2013/10/22).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  57. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56 (Epub 2001/03/17).

    CAS  PubMed  Article  Google Scholar 

  58. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59(3):255–63 (Epub 2004/03/20).

    PubMed  Article  Google Scholar 

  59. Furlotte C, Schwartz K, Koornstra JJ, Naster R. ‘Got a room for me?’ Housing experiences of older adults living with HIV/AIDS in Ottawa. Can J Aging. 2012;31(1):37–48 (Epub 2012/02/22).

    PubMed  Article  Google Scholar 

  60. Pitts M, Grierson J, Misson S. Growing older with HIV: a study of health, social and economic circumstances for people Living with HIV in Australia over the age of 50 years. AIDS Patient Care STDS. 2005;19(7):460–5.

    PubMed  Article  Google Scholar 

  61. Liddy C, Johnston S, Guilcher S, Irving H, Hogel M, Jaglal S. Impact of a chronic disease self-management program on healthcare utilization in eastern Ontario, Canada. Prev Med Rep. 2015;2:586–90 (Epub 2016/02/05).

    PubMed  PubMed Central  Article  Google Scholar 

  62. Pullen S. Physical therapy as non-pharmacological chronic pain management of adults living with HIV: self-reported pain scores and analgesic use. HIV/AIDS. 2017;9:177.

    Google Scholar 

  63. Nosrat S, Whitworth JW, Ciccolo JT. Exercise and mental health of people living with HIV: a systematic review. Chronic Illn. 2017;13(4):299–319 (Epub 2017/11/10).

    PubMed  Article  Google Scholar 

  64. Dixon G, Thornton EW, Young CA. Perceptions of self-efficacy and rehabilitation among neurologically disabled adults. Clin Rehabil. 2007;21(3):230–40 (Epub 2007/03/03).

    PubMed  Article  Google Scholar 

  65. Wojkowski S, Ahluwalia P, Radassao K, Wharin C, Walker G, Rushford N. Role-emerging clincial placements in a community-based HIV organization—opportunities for interprofessional collaboration: a case report. Physiother Can. 2019;71(4):384–90.

    PubMed  Article  PubMed Central  Google Scholar 

  66. Solomon P, Salbach NM, O’Brien KK, Nixon S, Baxter L, Gervais N. Evaluation of a community-based self-management program to increase access to rehabilitation for people living with HIV. J Int Assoc Provid AIDS Care. 2019;18:2325958219883334 (Epub 2019/10/23).

    PubMed  PubMed Central  Article  Google Scholar 

  67. Solomon P, Salbach N, O’Brien KK, Worthington C, Baxter L, Blanchard G, et al. Increasing capacity in rehabilitation in the management of HIV: a case-based e-mail intervention. Barcelona: AIDS Impact Conference; 2013.

    Google Scholar 

  68. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–95 (Epub 2005/09/01).

    PubMed  PubMed Central  Article  Google Scholar 

  69. Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008;8:24 (Epub 2008/10/02).

    PubMed  PubMed Central  Article  Google Scholar 

  70. O’Brien KK, Bayoumi AM, King K, Alexander R, Solomon P. Community engagement in health status instrument development: experience with the HIV disability questionnaire. Prog Commun Health Partn. 2014;8(4):549–59 (Epub 2014/01/01).

    Article  Google Scholar 

  71. Travers R, Wilson MG, Flicker S, Guta A, Bereket T, McKay C, et al. The greater involvement of people living with AIDS principle: theory versus practice in Ontario’s HIV/AIDS community-based research sector. AIDS Care. 2008;20(6):615–24 (Epub 2008/06/26).

    CAS  PubMed  Article  Google Scholar 

  72. Solomon P, O’Brien KK, Baxter L, MacLachlan D, Robinson G. Community involvement in development of evidence-informed recommendations for rehabilitation for older adults living with HIV. Prog Community Health Partn. 2016;10(1):83–8.

    Article  Google Scholar 

  73. Ibanez-Carrasco F, Watson JR, Tavares J. Supporting peer researchers: recommendations from our lived experience/expertise in community-based research in Canada. Harm Reduct J. 2019;16(1):55 (Epub 2019/09/05).

    PubMed  PubMed Central  Article  Google Scholar 

  74. Canadian Instutites of Health Research (CIHR). Strategy for Patient-Oriented Research (SPOR). 2019 [cited 2019 September 20, 2019]; http://www.cihr-irsc.gc.ca/e/41204.html.

  75. Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC). 2019 [cited 2019 November 17, 2019]; http://cihrrc.hivandrehab.ca/.

  76. Cobbing S, Hanass-Hancock J, Myezwa H. Home-based rehabilitation interventions for adults living with HIV: a scoping review. Af J AIDS Res. 2016;15(1):77–88.

    Article  Google Scholar 

  77. Cobbing S, Hanass-Hancock J, Myezwa H. A home-based rehabilitation intervention for adults living with HIV: a randomized controlled trial. J Assoc Nurses AIDS Care. 2017;28(1):105–17.

    PubMed  Article  Google Scholar 

  78. Roos R, Myezwa H, van Aswegen H, Musenge E. Effects of an education and home-based pedometer walking program on ischemic heart disease risk factors in people infected with HIV: a randomized trial. J Acquir Immune Defic Syndr. 2014;67(3):268–76 (Epub 2014/08/21).

    PubMed  Article  Google Scholar 

  79. Chetty V, Hanass-Hancock J. A rehabilitation model as key to comprehensive care in the era of HIV as a chronic disease in South Africa. AIDS Care. 2016;28(Suppl 1):132–9.

    PubMed  PubMed Central  Article  Google Scholar 

  80. Brothers TD, Kirkland S, Theou O, Zona S, Malagoli A, Wallace LMK, et al. Predictors of transitions in frailty severity and mortality among people aging with HIV. PLoS ONE. 2017;12(10):e0185352 (Epub 2017/10/06).

    PubMed  PubMed Central  Article  CAS  Google Scholar 

  81. O’Brien KK, Davis AM, Strike C, Young NL, Bayoumi AM. Putting episodic disability into context: a qualitative study exploring factors that influence disability experienced by adults living with HIV/AIDS. J Int AIDS Soc. 2009;12(1):5 (Epub 2009/11/11).

    PubMed  Article  Google Scholar 

  82. Solomon P, O’Brien KK, Nixon S, Letts L, Baxter L, Gervais N. Trajectories of episodic disability in people aging with HIV: a Longitudinal Qualitative Study. J Int Assoc Provid AIDS Care. 2018;17:2325958218759210.

    PubMed  PubMed Central  Article  Google Scholar 

  83. Solomon P, O’Brien K, Wilkins S, Gervais N. Aging with HIV and disability: the role of uncertainty. AIDS Care. 2014;26(2):240–5 (Epub 2013/06/27).

    PubMed  Article  Google Scholar 

  84. O’Brien KK, Hanna S, Solomon P, Worthington C, Ibanez-Carrasco F, Chan Carusone S, et al. Characterizing the disability experience among adults living with HIV: a structural equation model using the HIV disability questionnaire (HDQ) within the HIV, health and rehabilitation survey. BMC Infect Dis. 2019;19(1):594 (Epub 2019/07/10).

    PubMed  PubMed Central  Article  CAS  Google Scholar 

  85. Solomon P, Letts L, O’Brien KK, Nixon S, Baxter L, Gervais N. ‘I’m still here, I’m still alive’: understanding successful aging in the context of HIV. Int J STD AIDS. 2018;29(2):172–7 (Epub 2017/07/22).

    PubMed  Article  Google Scholar 

  86. Solomon P, O’Brien K, Wilkins S, Gervais N. Aging with HIV: a model of disability. J Int Assoc Provid AIDS Care. 2014;13(6):519–25 (Epub 2014/08/26).

    PubMed  Article  Google Scholar 

  87. Rueda S, Chambers L, Wilson M, Mustard C, Rourke SB, Bayoumi A, et al. Association of returning to work with better health in working-aged adults: a systematic review. Am J Public Health. 2012;102(3):541–56 (Epub 2012/03/07).

    PubMed  PubMed Central  Article  Google Scholar 

  88. Rueda S, Raboud J, Rourke SB, Bekele T, Bayoumi A, Lavis J, et al. Influence of employment and job security on physical and mental health in adults living with HIV: cross-sectional analysis. Open Med. 2012;6(4):e118–26 (Epub 2012/01/01).

    PubMed  PubMed Central  Google Scholar 

  89. Greene M, Hessol NA, Perissinotto C, Zepf R, Hutton Parrott A, Foreman C, et al. Loneliness in older adults living with HIV. AIDS Behav. 2018;22(5):1475–84 Epub 2017/11/21.

    PubMed  PubMed Central  Article  Google Scholar 

  90. Furlotte C, Schwartz K. Mental health experiences of older adults living with HIV: uncertainty, stigma, and approaches to resilience. Can J Aging. 2017;36(2):125–40.

    PubMed  Article  Google Scholar 

  91. Emlet CA, Shiu C, Kim HJ, Fredriksen-Goldsen K. Bouncing back: resilience and mastery among HIV-positive older gay and bisexual men. Gerontologist. 2017;57(suppl 1):S40–9.

    PubMed  PubMed Central  Article  Google Scholar 

  92. Bernardin KN, Toews DN, Restall GJ, Vuongphan L. Self-management interventions for people living with human immunodeficiency virus: a scoping review. Can J Occup Ther. 2013;80(5):314–27 (Epub 2014/03/20).

    PubMed  Article  Google Scholar 

  93. O’Brien KK, Dagenais M, Solomon P, Worthington C, Chan Carusone S, Ibanez-Carrasco F, et al. Use of living strategies among adults aging with HIV in Canada: comparison by age-group using data from the HIV, health and rehabilitation survey. J Int Assoc Provid AIDS Care. 2018;17:2325958218774041.

    PubMed  PubMed Central  Article  Google Scholar 

  94. Heissel A, Zech P, Rapp MA, Schuch FB, Lawrence JB, Kangas M, et al. Effects of exercise on depression and anxiety in persons living with HIV: a meta-analysis. J Psychosom Res. 2019;126:109823 (Epub 2019/09/14).

    PubMed  Article  Google Scholar 

  95. Vancampfort D, Mugisha J, De Hert M, Probst M, Firth J, Gorczynski P, et al. Global physical activity levels among people living with HIV: a systematic review and meta-analysis. Disabil Rehabil. 2018;40(4):388–97 (Epub 2016/12/09).

    PubMed  Article  Google Scholar 

  96. O’Brien KK, Tynan AM, Nixon SA, Glazier RH. Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol. BMC Infect Dis. 2017;17(1):268.

    PubMed  PubMed Central  Article  Google Scholar 

  97. O’Brien KK, Tynan AM, Nixon SA, Glazier RH. Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol. BMC Infect Dis. 2016;16(1):182.

    PubMed  PubMed Central  Article  Google Scholar 

  98. O’Brien KK, Bayoumi AM, Solomon P, Tang A, Murzin K, Chan Carusone S, et al. Evaluating a community-based exercise intervention with adults living with HIV: protocol for an interrupted time series study. BMJ Open. 2016;6(10):e013618 (Epub 2016/11/01).

    PubMed  PubMed Central  Article  Google Scholar 

  99. Quigley A, O’Brien KK, Brouillette MJ, MacKay-Lyons M. Evaluating the feasibility and impact of a yoga intervention on cognition, physical function, physical activity, and affective outcomes in people living with HIV: protocol for a Randomized Pilot Trial. JMIR Res Protoc. 2019;8(5):e13818 (Epub 2019/05/23).

    PubMed  PubMed Central  Article  Google Scholar 

  100. Greene M, Justice A, Covinsky KE. Assessment of geriatric syndromes and physical function in people living with HIV. Virulence. 2017;8(5):586–98.

    PubMed  Article  Google Scholar 

  101. Piggott DA, Erlandson KM, Yarasheski KE. Frailty in HIV: epidemiology, biology, measurement, interventions, and research needs. Curr HIV/AIDS Rep. 2016;13(6):340–8 (Epub 2016/08/24).

    PubMed  PubMed Central  Article  Google Scholar 

  102. Brothers TD, Kirkland S, Guaraldi G, Falutz J, Theou O, Johnston BL, et al. Frailty in people aging with human immunodeficiency virus (HIV) infection. J Infect Dis. 2014;210(8):1170–9 (Epub 2014/06/07).

    PubMed  Article  Google Scholar 

  103. European AIDS Clinical Society (EACS). European AIDS Clinical Society (EACS) Guidelines, Version 10.0. London: European AIDS Clinical Society (EACS); 2019. p. 2019.

    Google Scholar 

  104. Kall M, Marcellin F, Harding R, Lazarus JV, Carrieri P. Patient-reported outcomes to enhance person-centred HIV care. Lancet HIV. 2019;7(1):e59–68 (Epub 2019/11/30).

    PubMed  Article  Google Scholar 

  105. Engler K, Lessard D, Lebouche B. A Review of HIV-Specific Patient-Reported Outcome Measures. The patient. 2017;10(2):187–202 Epub 2016/09/18.

    PubMed  Article  Google Scholar 

  106. O’Brien KK, Solomon P, Bergin C, O’Dea S, Stratford P, Iku N, et al. Reliability and validity of a new HIV-specific questionnaire with adults living with HIV in Canada and Ireland: the HIV Disability Questionnaire (HDQ). Health Qual Life Outcomes. 2015;13:124.

    PubMed  PubMed Central  Article  Google Scholar 

  107. Brown DA, Simmons B, Boffito M, Aubry R, Nwokolo N, Harding R, et al. Evaluation of the psychometric properties of the HIV Disability Questionnaire among adults living with HIV in the United Kingdom: a cross-sectional self-report measurement study. PLoS ONE. 2019;14(7):e0213222 (Epub 2019/07/11).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  108. O’Brien KK, Kietrys D, Galantino ML, Parrott JS, Davis T, Tran Q, et al. Reliability and validity of the HIV Disability Questionnaire (HDQ) with adults living with HIV in the United States. J Int Assoc Provid AIDS Care. 2019;18:2325958219888461 (Epub 2019/11/27).

    PubMed  PubMed Central  Article  Google Scholar 

  109. Fredericksen RJ, Fitzsimmons E, Gibbons LE, Loo S, Dougherty S, Avendano-Soto S, et al. How do treatment priorities differ between patients in HIV care and their providers? A Mixed-Methods Study. AIDS Behav. 2019;24(4):1170–80 (Epub 2019/12/14).

    Article  Google Scholar 

  110. Rankin NM, McGregor D, Butow PN, White K, Phillips JL, Young JM, et al. Adapting the nominal group technique for priority setting of evidence-practice gaps in implementation science. BMC Med Res Methodol. 2016;16(1):110 (Epub 2016/08/28).

    PubMed  PubMed Central  Article  Google Scholar 

  111. Cobbing S, Chetty V, Hanass-Hancock J, Jelsma J, Myezwa H, Nixon SA. Position paper: the essential role of physiotherapist in providing rehabilitation services to people living with HIV in South Africa. South Afr J Physiother. 2017;69(1):22–5.

    Google Scholar 

  112. Ibanez-Carrasco F, Terpstra A, Rourke S, Yamamoto A, Chan Carusone S, Baltzer Turje R, et al. Creating productive tensions: clinicians working with patients as peer researchers in a community-based participatory research study of the lived experience of HIV-associated neurocognitive disorder (HAND). Can J Action Res. 2018;19(3):53–72.

    Google Scholar 

Download references

Acknowledgements

The 3rd International Forum on HIV and Rehabilitation Research was led by the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC) (http://cihrrc.hivandrehab.ca/) in collaboration with the Canadian Association for HIV Research (CAHR) (www.cahr-acrv.ca/) and Realize (http://www.realizecanada.org/en/). We acknowledge the contributions of the stakeholders who participated in the meeting and/or contributed to refining the research priorities: Francisco Ibáñez-Carrasco (Ontario HIV Treatment Network, St. Michael’s Hospital); Kate Murzin (Realize); Patty Solomon (McMaster University); Charles Emlet (University of Washington); Julian Falutz (McGill University); Richard Harding (King’s College London); Rosalind Baltzer Turje (Dr. Peter AIDS Foundation); Patrick McDougall (Dr. Peter AIDS Foundation); Larry Baxter (Halifax, Nova Scotia); Darren Brown (Chelsea and Westminster Hospital NHS Foundation Trust); Gayle Restall (University of Manitoba); Puja Ahluwalia (Realize); Alan Casey (University of Manitoba); Adria Quigley (Dalhousie University); Esther McDonnell (Chelsea and Westminster Hospital NHS Foundation Trust); Tammy Yates (Realize); Chris Lucas (Nine Circles Community Health Centre); Tammy Reimer (Nine Circles Community Health Centre); Soo Chan Carusone (Casey House); Amrita Ahluwalia (Fife House Foundation); and Andrew Matejcic (Canadian Association for HIV Research). We acknowledge the following additional stakeholders who contributed to attending the Forum and/or developing these research priorities: Robert Alexander (Bruce House); Sunitha Bangalore (Karnataka Health Promotion Trust); Marie-Josée Brouillette (McGill University); Andre Ceranto (Fife House); Thomas Egdorf (CATIE); Marianne Harris (BC Centre for Excellence in HIV/AIDS); John Heath (Memorial University of Newfoundland); John McCullagh (Community Member); Irene Masinde (Africans in Partnership Against AIDS); Stephanie Nixon (University of Toronto); Fanta Ongoiba (Africans in Partnership Against AIDS); Chuck Osborne (BC Centre for Excellence in HIV/AIDS); Rachelle Paquette (University Health Network); Lori Peterson (Winnipeg Regional Health Authority); Suresh Ramadasan (Merck); Laurie Ringaert (Nine Circles Community Health Centre); Ron Rosenes (Ron Rosenes Consulting); Alexandria Simms (University of Manitoba); Theresa Sullivan (University of Manitoba); Joyce Thanes (Mood Disorders Association of Manitoba); James Watson (Ontario HIV Treatment Network); Catherine Worthington (University of Victoria); and Tammy Yates (Realize). The 3rd International Forum on HIV and Rehabilitation Research was funded by a Meeting, Planning and Dissemination (MPD) Grant from the Canadian Institutes of Health Research (CIHR), Aging Institute (FRN# 142085), and supported by the Canadian Association for HIV Research (CAHR) and Realize. We acknowledge support from the Gay Men’s Health Collective (GMHC), Three Flying Piglets, UK for filming (in-kind) (http://gaymenshealthcollective.co.uk/three-flying-piglets/), the Department of Physical Therapy, University of Toronto and the Ontario HIV Treatment Network (OHTN). We thank Ayesha Nayar (University of Toronto) and Sabdanna Jeyakumaran (University of Toronto) for their assistance with the meeting coordination. We thank Adria Quigley (Dalhousie University); Alex R. Terpstra (Ontario HIV Treatment Network); and Saipriya Vajravelu (McMaster University) for their role as graduate student rapporteurs at the Forum.

Funding

Funding for this meeting was supported by the Canadian Institutes of Health Research, Institute on Aging (CIHR) Grant: FRN# 142085. The CIHR had no role in the data collection, analysis or interpretation of data. Kelly K. O’Brien (KKO) is supported by a Canada Research Chair (CRC) in Episodic Disability and Rehabilitation. Alex R. Terpstra (ART) is supported by a Vanier Canada Graduate Scholarship.

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Authors and Affiliations

  1. Department of Physical Therapy, University of Toronto, 500 University Avenue, Room 160, Toronto, ON, Canada

    Kelly K. O’Brien & Nkem Ononiwu

  2. Institute of Health Policy, Management and Evaluation (IHPME), 155 College Street, 4th Floor, Toronto, ON, Canada

    Kelly K. O’Brien

  3. Rehabilitation Sciences Institute (RSI), University of Toronto, 500 University Avenue, Room 160, Toronto, ON, Canada

    Kelly K. O’Brien

  4. Centre for Urban Health Solutions, St. Michael’s Hospital, 30 Bond Street, Toronto, ON, Canada

    Francisco Ibáñez-Carrasco

  5. School of Rehabilitation Science, McMaster University, 1400 Main Street West, Room 403, Hamilton, ON, Canada

    Patricia Solomon

  6. Cicely Saunders Institute, King’s College London, Bessemer Road, London, UK

    Richard Harding

  7. Therapies Department, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK

    Darren Brown

  8. Realize, 600 Bay Street, Suite 600, Toronto, ON, Canada

    Puja Ahluwalia

  9. Casey House, 119 Isabella Street, Toronto, ON, Canada

    Soo Chan Carusone

  10. Halifax, NS, Canada

    Larry Baxter

  11. University of Washington, Tacoma, Social Work, 1900 Commerce Street, Tacoma, WA, USA

    Charles Emlet

  12. College of Rehabilitation Sciences, University of Manitoba, R127 Rehab Building, Winnipeg, MB, Canada

    Gayle Restall

  13. Department of Physical Medicine and Rehabilitation, University of Manitoba, 820 Sherbrook Street, Winnipeg, MB, Canada

    Alan Casey

  14. Fife House, 490 Sherbourne Street, Toronto, ON, Canada

    Amrita Ahluwalia

  15. Faculty of Health, Dalhousie University, 5968 College Street, Room 316, Halifax, NS, Canada

    Adria Quigley

  16. Department of Psychology, 2136 West Mall, Room 2405, Vancouver, BC, Canada

    Alex R. Terpstra

Authors
  1. Kelly K. O’Brien
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  2. Francisco Ibáñez-Carrasco
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Contributions

KKO and FIC led the planning and implementation of the meeting. KKO, FIC, PS, RH, DB, PA, SCC, LB, CE, GR, AC, AA, were speakers at the Forum and involved in the development of the research priorities. AQ and ART were student rapporteurs who documented the discussion at the Forum that contributed to the research priority development. KKO analyzed and interpreted the data regarding the research priorities. KKO, PS, FIC finalized the research priorities upon further consultation with the authorship team. KKO led the drafting and revision of the manuscript, NO contributed to drafting sections of earlier drafts the manuscript. All authors contributed to the review and revision. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Kelly K. O’Brien.

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Ethics approval and consent to participate

We consulted with the University of Toronto HIV/AIDS Research Ethics Board prior to the Forum who waived the need for ethical approval for this work as this was a consultation at an international meeting.

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Not applicable.

Competing interests

The authors declare that they have no competing interests.

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O’Brien, K.K., Ibáñez-Carrasco, F., Solomon, P. et al. Research priorities for rehabilitation and aging with HIV: a framework from the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC). AIDS Res Ther 17, 21 (2020). https://doi.org/10.1186/s12981-020-00280-5

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Keywords

  • HIV
  • Rehabilitation
  • Aging
  • Disability
  • Research priorities

AIDS Research and Therapy

ISSN: 1742-6405

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