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Table 4 Linear regression for the relationships between T-cell subsets and IFNL genotypes in mono-infected PLWH on ART with viral suppression

From: Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection

SNP

% CD4+ naïve

% CD4+ central memory

% CD4+ effector memory

Effect

95% CI

p value

Effect

95% CI

p value

Effect

95% CI

p value

rs12979860

 C/T

3.97

− 3.84; 11.78

0.31

− 2.40

− 8.00; 3.20

0.40

− 3.54

− 10.51; 3.43

0.31

 T/T

2.40

− 8.29; 13.08

0.66

− 0.64

− 8.30; 7.02

0.87

− 2.12

− 11.66; 7.42

0.66

rs368234815

 T/ΔG

0.18

− 7.77; 8.13

0.97

1.16

− 4.48; 6.81

0.68

− 1.58

− 8.62; 5.45

0.66

 ΔG/ΔG

0.61

− 8.35; 9.57

0.89

3.42

− 2.94; 9.77

0.29

− 4.24

− 12.16; 3.69

0.29

rs12979860

 C/T

3.19

− 2.94; 9.31

0.30

0.45

− 4.73; 5.64

0.86

− 7.59

− 15.16; − 0.03

0.049

 T/T

6.78

− 1.60; 15.16

0.11

− 3.96

− 11.05; 3.14

0.27

− 5.82

− 16.18; 4.53

0.27

rs368234815

 T/ΔG

2.15

− 3.96; 8.27

0.48

0.86

− 4.44; 6.17

0.75

− 3.19

− 10.89; 4.50

0.41

 ΔG/ΔG

7.17

0.28; 14.06

0.042

− 0.53

− 6.50; 5.44

0.86

− 7.62

− 16.29; 1.05

0.08

  1. C/C is the reference group for rs12979860 and T/T is the reference group for rs368234815