Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection

Table 3 Linear regression for the relationships between T-cell subsets and IFNL genotypes in PLWH on ART with viral suppression (N = 111)

SNP	% CD4⁺ naïve			% CD4⁺ central memory			% CD4⁺ effector memory
SNP	Effect	95% CI	p value	Effect	95% CI	p value	Effect	95% CI	p value
rs12979860
C/T	3.55	− 2.16; 9.25	0.22	− 1.59	− 6.00; 2.83	0.48	− 2.97	− 83.6; 2.42	0.28
T/T	2.00	− 6.27; 10.26	0.63	2.73	− 3.68; 9.13	0.40	− 3.58	− 11.40; 4.23	0.37
rs368234815
T/ΔG	1.05	− 4.71; 6.81	0.72	0.62	− 3.78; 5.03	0.78	− 1.72	− 7.06; 3.62	0.53
ΔG/ΔG	2.51	− 4.76; 9.78	0.50	5.36	− 0.20; 10.92	0.06	− 7.08	− 13.83; − 0.34	0.04
rs12979860
C/T	1.44	− 3.03; 6.19	0.55	2.19	− 1.91; 9.28	0.29	− 4.40	− 10.00; 1.19	0.12
T/T	2.55	− 4.33; 9.43	0.46	0.70	− 5.23; 6.64	0.82	− 1.63	− 9.73; 6.48	0.69
rs368234815
T/ΔG	0.05	− 4.71; 4.80	0.98	3.10	− 0.99; 7.19	0.14	− 1.37	− 7.03; 4.29	0.63
ΔG/ΔG	3.03	− 2.98; 9.03	0.32	2.48	− 2.68; 7.64	0.34	− 3.42	− 10.57; 3.73	0.35

C/C is the reference group for rs12979860 and T/T is the reference group for rs368234815

ISSN: 1742-6405