Skip to main content

Table 2 Incidence density rates of hypersensitivity reactions within 42 days of abacavir initiation, by screening period

From: HLA-B*57:01 screening and hypersensitivity reaction to abacavir between 1999 and 2016 in the OPERA® observational database: a cohort study

Adjudicated hypersensitivity reaction definition Screening period Hypersensitivity reaction events Person-days on abacavir Incidence rate per 100,000 person-days (95% CI) Post- vs. pre-screening incidence rate ratio (95% CI)
Any hypersensitivity reactiona Pre-screeningb 51 129,856 39 (30, 52) 1.00 (Ref)
Post-screeningc 37 232,905 16 (12, 22) 0.36 (0.23, 0.55)
Definitive/probable hypersensitivity reactiond Pre-screeningb 42 129,856 32 (23, 44) 1.00 (Ref)
Post-screeningc 27 232,905 12 (8, 17) 0.31 (0.19, 0.52)
  1. aDefined as definite, probable or possible hypersensitivity reaction diagnoses
  2. bPre-screening period: 01 January 1999 to 14 June 2008
  3. cPost-screening period: 15 June 2008 to 31 July 2016
  4. dDefined as definite or probable hypersensitivity reaction diagnoses only