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Table 1 Demographic and clinical characteristics at index date, by screening period

From: HLA-B*57:01 screening and hypersensitivity reaction to abacavir between 1999 and 2016 in the OPERA® observational database: a cohort study

Characteristic Pre-screening perioda
n (%) or median (IQR)
Post-screening periodb
n (%) or median (IQR)
p-value
N 3215 (33) 6404 (67)  
Age, years 40 (34–46) 44 (34–52) < 0.0001
Male sex 2759 (86) 5330 (83) < 0.0001
African American 865 (27) 2375 (37) < 0.0001
Hispanic ethnicity 615 (19) 1546 (24) < 0.0001
Men who have sex with men 1969 (61) 3045 (48) < 0.0001
Antiretroviral therapy naïve 1188 (37) 2752 (43) < 0.0001
HIV RNA, log10 copies/mL 3.9 (2.2–4.8) 2.0 (1.3–4.5) < 0.0001
HIV RNA < 50 copies/mL 355 (11) 2625 (41) < 0.0001
CD4 cell count 274 (142–452) 452 (270–660) < 0.0001
History of AIDS-defining event 965 (30) 959 (15) < 0.0001
  1. aPre-screening period: 01 January 1999 to 14 June 2008
  2. bPost-screening period: 15 June 2008 to 31 July 2016