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Table 1 Demographic and clinical characteristics at index date, by screening period

From: HLA-B*57:01 screening and hypersensitivity reaction to abacavir between 1999 and 2016 in the OPERA® observational database: a cohort study

Characteristic

Pre-screening perioda

n (%) or median (IQR)

Post-screening periodb

n (%) or median (IQR)

p-value

N

3215 (33)

6404 (67)

 

Age, years

40 (34–46)

44 (34–52)

< 0.0001

Male sex

2759 (86)

5330 (83)

< 0.0001

African American

865 (27)

2375 (37)

< 0.0001

Hispanic ethnicity

615 (19)

1546 (24)

< 0.0001

Men who have sex with men

1969 (61)

3045 (48)

< 0.0001

Antiretroviral therapy naïve

1188 (37)

2752 (43)

< 0.0001

HIV RNA, log10 copies/mL

3.9 (2.2–4.8)

2.0 (1.3–4.5)

< 0.0001

HIV RNA < 50 copies/mL

355 (11)

2625 (41)

< 0.0001

CD4 cell count

274 (142–452)

452 (270–660)

< 0.0001

History of AIDS-defining event

965 (30)

959 (15)

< 0.0001

  1. aPre-screening period: 01 January 1999 to 14 June 2008
  2. bPost-screening period: 15 June 2008 to 31 July 2016