From: Looking at the positives: proactive management of STIs in people with HIV
Approach | Method | Use | Features |
---|---|---|---|
Direct detection | Dark ground microscopy PCR | Â | Require exudates and fluids from lesions PCR improving diagnostic thresholds |
Treponemal tests | EIA TPHA/TPPA Western blot (IgG or IgM) | Screening | Highly sensitive Do not correlate with disease activity |
Non-treponemal tests (against anti-cardiolipin antibodies) | VDRL RPR | Monitor treatment response Qualitative titre | Correlate with disease activity and treatment response Risk of false positive results |