Variables | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | |
Gender | ||||||
Male | Ref | |||||
Female | 1.99 | (1.5–2.64) | < 0.001 | 2.47 | (1.71–3.56) | < 0.001 |
Age, (per year older) | 1.001 | (0.98–1.02) | 0.906 | |||
Body mass index (BMI, kg/m2) | ||||||
< 25 | 1.11 | (0.75–1.64) | 0.606 | |||
≥ 25 | Ref | |||||
Pre–cART HIV-RNA level (log10 copies/mL) | 0.79 | (0.65–0.96) | 0.017 | |||
Pre-cART CD4 count (per 100 cell/mm3 increased) | 1.40 | (1.28–1.54) | < 0.001 | |||
Pre-cART CD4 count (cells/mm3) | < 0.001 | < 0.001 | ||||
0–200 | Ref | Ref | ||||
201–350 | 2.05 | (1.5–2.81) | < 0.001 | 1.95 | (1.4–2.72) | < 0.001 |
≥ 351 | 3.47 | (2.31–5.2) | < 0.001 | 3.62 | (2.36–5.55) | < 0.001 |
Pre-cART CD8 count (per 50 cell/mm3 increase) | 0.99 | (0.97–1.004) | 0.139 | |||
CDC grading | ||||||
A, or B | 1.81 | (1.1–2.99) | 0.019 | 1.2 | (0.71–2.02) | 0.503 |
C | Ref | Ref | ||||
Months since ART start to first virological suppression | 0.057 | 0.25 | ||||
< 6 months | Ref | Ref | ||||
6–12 months | 0.48 | (0.22–1.06) | 0.07 | 1.30 | (0.84–2.02) | 0.24 |
≥ 12 months | 1.14 | (0.79–1.64) | 0.49 | 1.49 | (0.89–2.51) | 0.13 |
HBsAg status | ||||||
Negative | 1.62 | (1.04–2.52) | 0.04 | 1.26 | (0.79–2.01) | 0.33 |
Positive | Ref | Ref | ||||
Anti-HCV Ab status | ||||||
Negative | 1.08 | (0.65–1.81) | 0.76 | |||
Positive | Ref | |||||
Baseline ARV regimen | 0.017 | 0.14 | ||||
NNRTI based | Ref | |||||
PI based | 1.50 | (1.13–1.99) | 0.01 | 1.35 | (0.99–1.82) | 0.051 |
INSTI based | 2.01 | (0.49–8.27) | 0.33 | 1.60 | (0.38–6.70) | 0.52 |
cART by calendar year | ||||||
< 2007 | Ref | |||||
≥ 2007 | 0.85 | (0.61–1.2) | 0.37 |