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Table 3 Baseline demographics of HIV-positive MSM enrolled in clinical trial

From: Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine in HIV-positive Spanish men who have sex with men (MSM)

 

HIV-MSM vaccine (n = 66)

HIV-MSM placebo (n = 63)

p*

Age, years; mean (±SD)

37.3 (±10.6)

40.5 (±10.02)

0.082

Spanish nationality, n (%)

63 (95.5)

60 (95.2)

0.2

University education, n (%)

34 (51.5)

35 (55.5)

0.56

Partners in the previous 12 months; median (IQR)

1 (1–3)

1 (1–5)

0.8

Life-time partners; n, median (IQR)

50 (20–300)

100 (45–350)

0.041*

Years of sexual activity; median (IQR)

17 (9–24)

21 (13–27)

0.025*

Condom use, n (%)

53 (80.3)

47 (74.6)

0.4

Perianal/genital condylomas at screening, n (%)

20 (30.3)

20 (31.7)

0.86

History of condylomas, n (%)

19 (28.8)

15 (23.8)

0.52

Duration of HIV; mean months (IQR)

58 (26–120)

77 (37–138)

0.2

History of AIDS; n (%)

19 (28.8)

21 (33.3)

0.58

CD4 mean nadir; cells/µL, (±SD)

336 (±227.3)

334.2 (±193.7)

0.96

CD4 mean; cells/µL (±SD)

733 (±252.7)

710.4 (±266.6)

0.62

CD8 mean; cells/µL (±SD)

999.9 (±463.6)

992.2 (±374.9)

0.98

VL of HIV log10; copies/mL (±SD)

3.76 (±4.5)

3.67 (±4.46)

0.8

VL <50 copies/mL, n (%)

53 (80.3)

53 (84.1)

0.57

Virological failure, n (%)

1 (1.5)

3 (4.8)

0.29

Median duration of ART; months (IQR)

42 (17–86)

43 (17–129)

0.42

Number of lines of ART, median (IQR)

1 (1–2)

1 (1–2)

0.56

Syphilis treated, n (%)

16 (24.2)

12 (19.1)

0.47

Other STD, n (%)

11 (16.6)

12 (19.1)

0.72

Latent tuberculosis treated, n (%)

5 (7.6)

10 (15.9)

0.14

HCV, n (%)

2 (3)

2 (3.2)

1

HBV, n (%)

2 (3)

0 (0)

0.49

Smoking, packets/year, median (IQR)

0.2 (0–1)

6.5 (0–18)

0.008*

Ex-smoking, n (%)

10 (15)

13 (20.6)

0.0.42

Ex-IVDA, n (%)

1 (1.5)

0 (0)

0.42

Alcohol (standard units of alcohol; SUA)

0 (0–1)

0.4 (0–1.4)

0.15

  1. p*: p < 0.05
  2. * After applying the FDR correction for multiple comparisons, none of the 3 variables we statistically significant