Table 2 Potential gene therapy targets for HIV-1 therapy

Gag

Proteolytic processing of the HIV-1 genome

[135, 136]

Pol

Transcription

[137]

env

Receptor binding and fusion

[138, 139]

tat

Transcription or RNAi modulation

[140]

rev

Reverse transcription, integration

[141]

nef

Immune modulation

[124, 142,143,144,145]

pol (integrase)

Integration

[146, 147]

pol (reverse transcriptase)

Reverse transcription

[148]

Promoter

Transcription

[149]

Long terminal repeats

Genome expression

[145, 150]

P17

Assembly and budding of HIV-1

[68]

Cellular targets

 CCR5

Receptor binding and fusion

[151]

 CD4

Receptor binding and fusion

 CXCR4

Receptor binding and fusion

[152, 153]

 Chaperonin

Integration

[154]

 LEDGF/p75

Integration

[155]

 Importin-7

Integration

[156]

 Cyclin T1

Transcription

[157]

 P-TEFb

Transcription

[158]

 Tat-SF1

Transcription

[159]

 SPT5

Transcription

[160]

 DDX3

Export

[161]

 SOCS1

Trafficking or immune modulation

[162]

 TRBP

Immune modulation or RNAi pathway

[163, 164]

 TNPO3

Nuclear entry of viral pre-integration complex

[141, 165]