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Table 5 Proportion of abnormal values for CVD risk factors and differences in mean values of CVD risk measures by PI exposure among the 964 adults on ART for more than 6 months

From: COHORT PROFILE: The Complications of Long-Term Antiretroviral Therapy study in Uganda (CoLTART), a prospective clinical cohort

CVD risk measure

Abnormal values for CVD risk, n (%)

ADJUSTED mean differences (95% CI), non-PI as reference

p value

Total cholesterol ≥5.2 μmol/l

 Non-PI regimen

176/714 (24.6%)

Ref

<0.001

 PI regimen

121/230 (52.6%)

0.78 (0.57 to 0.98)

HDL <1 mmol/l (males), <1.3 mmol/l (females)

 Non-PI regimen

265/714 (37.1%)

Ref

0.001

 PI regimen

67/230 (29.1%)

0.12 (0.05 to 0.20)

LDL ≥3.4 mmol/l

 Non-PI regimen

144/714 (18.6%)

Ref

<0.001

 PI regimen

93/230 (40.3%)

0.45 (0.29 to 0.62)

Total cholesterol/HDL ratio (>5.1)

 Non-PI regimen

90/714 (12.6%)

Ref

0.420

 PI regimen

42/230 (18.3%)

0.10 (−0.15 to 0.35)

Triglycerides ≥1.69 mmol/l

 Non-PI regimen

109/713 (15.3%)

Ref

<0.001

 PI regimen

99/230 (43.0%)

0.52 (0.24 to 0.80)

Glucose (>6.4 mmol/l)

 Non-PI regimen

26/714 (3.6%)

Ref

0.814

 PI regimen

7/231 (3.0%)

0.00 (−0.03 to 0.04)

Systolic blood pressure (≥140 mmHg)

 Non-PI regimen

110/707 (15.6%)

Ref

0.060

 PI regimen

19/234 (8.1%)

−3.120 (−6.413 to 0.174)

Diastolic blood pressure (≥90 mmHg)

 Non-PI regimen

112/707 (15.8%)

Ref

<0.001

 PI regimen

13/234 (5.6%)

−3.931 (−5.967 to 1.895)

AIP log10 (Triglycerides/HDL) ≥0.1

 Non-PI regimen

183/713 (25.7%)

Ref

<0.001

 PI regimen

102/230 (44.3%)

0.12 (0.07 to 0.17)

Abnormal BMI (≥30 kg/m2)

 Non-PI regimen

44/703 (6.3%)

Ref

0.074

 PI regimen

17/231 (7.3%)

−2.370 (−5.005 to 0.264)

Abnormal waist circumference [≥94 cm (men)/≥80 (women)]

 Non-PI regimen

287/706 (40.6%)

Ref

0.805

 PI regimen

94/234 (40.2%)

−0.202 (−1.829 to 1.425)

Abnormal waist/hips ratio [>0.95 (men)/>85 (women)]

 Non-PI regimen

369/706 (52.3%)

Ref

0.118

 PI regimen

133/234 (56.8%)

0.008 (−0.002 to 0.019)

Abnormal Framingham score (>10%)

 Non-PI regimen

130/703 (18.5%)

Ref

0.434

 PI regimen

28/229 (12.2%)

−0.344 (−1.218 to 0.530)

  1. Mean differences adjusted for site, duration on ART, sex, age-groups, smoking status, alcohol consumption, days/week-animal proteins, salt and sugar intake, physical activity, social-economic status, log viral load, CD4 cell count
  2. HDL high density lipoprotein, LDL Low Density Lipoprotein, AIP atherogenic index for plasma, BMI body mass index
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AIDS Research and Therapy

ISSN: 1742-6405

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