Table 4 Proportion of renal dysfunction/failure, and adjusted mean differences in renal function measures by TDF exposure among 964 adults on ART for more than 6 months
Renal function assessment parameter | Renal dysfunction/failure, n (%) | Adjusted mean differences (95% CI), non-TDF as reference | p value |
|---|---|---|---|
eGFR (Cockcroft-Gault, adj for BSA) | |||
 Non-TDF | 99/378 (26.2%) | Ref | 0.797 |
 TDF | 142/501 (28.3%) | −2.15 (−8.53 to 4.22) | |
 TDF-stopped | 14/50 (28.0%) | −0.62 (−12.74 to 11.50) | |
eGFR (Cockcroft-Gault, without BSA adj) | |||
 Non-TDF | 141/379 (37.2%) | Ref | 0.914 |
 TDF | 196/502 (39.0%) | −2.42 (−14.45 to 9.62) | |
 TDF-stopped | 19/50 (38.0%) | −3.01 (−25.90 to 19.89) | |
eGFR (CKD-Epi) | |||
 Non-TDF | 60/383 (15.7%) | Ref | 0.837 |
 TDF | 109/514 (21.2%) | −0.88 (−3.84 to 2.08) | |
 TDF-stopped | 9/50 (18.0%) | −0.78 (−6.42 to 4.87) | |
eGFR (MDRD with race) | |||
 Non-TDF | 28/383 (7.3%) | Ref | 0.872 |
 TDF | 57/514 (11.1%) | −0.61 (−8.09 to 6.87) | |
 TDF-stopped | 4/50 (8.0%) | 3.11 (−11.14 to 17.36) | |
Fractional tubular PO4 reabsorption | |||
 Non-TDF | 16/339 (4.7%) | Ref | 0.131 |
 TDF | 16/386 (4.1%) | −0.74 (−1.84 to 0.36) | |
 TDF-stopped | 1/42 (2.4%) | 1.12 (−0.92 to 3.15) | |
Serum urea | |||
 Non-TDF | 0/382 (0.0%) | Ref | 0.252 |
 TDF | 2/514 (0.4%) | 0.03 (−0.19 to 0.25) | |
 TDF-stopped | 0/50 (0.0%) | 0.35 (−0.07 to 0.77) | |
Serum creatinine (μmol/l) | |||
 Non-TDF | 4/383 (1.0%) | Ref | 0.336 |
 TDF | 10/514 (1.9%) | 2.03 (−1.40 to 5.46) | |
 TDF-stopped | 3/50 (6.0%) | 3.98 (−2.55 to 10.51) | |
Serum phosphates (mmol/l) | |||
 Non-TDF | 64/383 (16.7%) | Ref | 0.575 |
 TDF | 50/503 (9.9%) | 0.01 (−0.04 to 0.06) | |
 TDF-stopped | 8/48 (16.7%) | −0.04 (−0.13 to 0.05) | |