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Table 2 Comparison of nevirapine pharmacokinetic parameters pre- and post- moringa

From: Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study

Parameter

GM (CV %)a

GMR (90% CI)a

Pre-moringa

Post-moringa

Post/Pre

P

AUC0–12h (h*µg/mL)

94.17 (25.24)

100.44 (27.65)

1.07 (1.00–1.14)

0.131

C12h (µg/mL)

7.30 (25.85)

7.55 (28.56)

1.03 (0.92–1.16)

0.702

Cmax,ss (µg/mL)

9.92 (26.93)

10.57 (29.62)

1.06 (0.98–1.16)

0.261

  1. aPost-moringa/pre-moringa geometric mean ratios (GMRs) and their confidence intervals were calculated as follows: GM[x] = 10^{m} ean[log[x]];GMR[y/x] = GM[y]/GM[x]
  2. GMR geometric mean ratio, CI confidence interval, AUC 0–12h area under the time-concentration curve from 0 to 12 h after dosing, C max,ss maximum concentration, C 12h concentration at the end of the dosing interval
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