Table 3 ART in HIV-infected patients with cryptococcosis

Time to start ART

 Deferred until 5 weeks after the start of antifungal therapy

ART regimen

 Consider drug–drug interactions between fluconazole and antiretroviral agents

  Fluconazole may potentially increase PI concentrations, but no clinical significance

  Fluconazole has the potential to increase NNRTI concentration

   No significant interactions with efavirenz

   Nevirapine has the most potential clinical relevance^a

   No significant interactions with rilpivirine

 Monitor closely for nevirapine-associated adverse events, including hepatotoxicity