Renal function assessment parameter | Tenofovir (TDF) ART exposure | duration on TDF or non-TDF containing ART | ||||
---|---|---|---|---|---|---|
TDF versus non-TDF | P value* | Non-TDF 9 + y versus non-TDF < 9y | TDF < 9y versus non-TDF < 9y | TDF 9 + y versus non-TDF < 9y | P value* | |
aMD (95 % CI)a | aMD (95 % CI)a | aMD (95 % CI)a | aMD (95 % CI)a | |||
eGFR (Cockcroft-Gault, with BSA adj) | −2.26 (−8.46 to 3.94) | 0.472 | −2.97 (−13.97 to 8.03) | 3.79 (−6.68 to 14.26) | −7.39 (−18.10 to 3.32) | 0.200 |
eGFR (Cockcroft-Gault, without BSA adj) | −2.79 (−14.50 to 8.93) | 0.638 | −4.40 (−25.21 to 16.42) | 1.30 (−18.50 to 21.11) | −8.43 (−28.70 to 11.84) | 0.778 |
eGFR (CKD-Epi) | −0.97 (−3.85 to 1.91) | 0.507 | −0.32 (−5.44 to 4.79) | 2.92 (−1.95 to 7.80) | −2.83 (−7.82 to 2.16) | 0.114 |
eGFR (MDRD with race adj) | −0.30 (−7.58 to 6.98) | 0.935 | −2.68 (−15.61 to 10.25) | 7.26 (−5.05 to 19.57) | −5.77 (−18.37 to 6.83) | 0.248 |
Fractional tubular PO4 reabsorption, % (SD) | −0.47 (−1.54 to 0.61) | 0.390 | −0.16 (−2.01 to 1.68) | −0.86 (−2.63 to 0.91) | −0.44 (−2.24 to 1.36) | 0.786 |
Urea BUN | 0.07 (−0.14 to 0.29) | 0.503 | −0.05 (−0.43 to 0.33) | 0.28 (−0.08 to 0.65) | −0.05 (−0.43 to 0.32) | 0.302 |
Serum creatinine (µmol/L) | 2.47 (−0.86 to 5.81) | 0.143 | −2.51 (−8.44 to 3.42) | −1.53 (−7.17 to 4.12) | 1.81 (−3.97 to 7.59) | 0.161 |
Serum phosphates (mmol/L) | 0.00 (−0.04 to 0.05) | 0.913 | −0.01 (−0.09 to 0.08) | 0.03 (−0.05 to 0.11) | −0.01 (−0.09 to 0.07) | 0.823 |