Table 2 Renal dysfunction or failure and mean values of renal function assessment parameters among patients with and without Tenofovir Disoproxil Fumarate containing ART regimen
Renal function assessment parameter | All participants n (%) | TDF exposure | P value* | |
|---|---|---|---|---|
Non-TDF ART n (%) | TDF ART n (%) | |||
All | 953 | 385 (40.4) | 568 (59.6) | |
eGFR (Cockcroft-Gault, adj for BSA), mean (SD) | 108.6 (37.0) | 110.0 (36.0) | 107.3 (36.8) | 0.197 |
Normal | 901 (97.0) | 371 (97.6) | 530 (96.5) | 0.338 |
Renal dysfunction/failure | 28 (3.0) | 9 (2.4) | 19 (3.5) | |
eGFR (Cockcroft-Gault, without BSA adj), mean (SD) | 104.9 (68.4) | 103.6 (58.9) | 104.6 (71.3) | 0.933 |
Normal | 874 (93.9) | 363 (95.3) | 511 (92.9) | 0.139 |
Renal dysfunction/failure | 57 (6.1) | 18 (4.7) | 39 (7.1) | |
eGFR (CKD-Epi), mean (SD) | 102.9 (18.0) | 105.3 (17.5) | 101.7 (18.2) | 0.001 |
Normal | 929 (98.1) | 378 (98.2) | 551 (98.0) | 0.878 |
Renal dysfunction/failure | 18 (1.9) | 7 (1.8) | 11 (2.0) | |
eGFR (MDRD with race), mean(SD) | 131.7 (43.8) | 135.9 (47.0) | 128.9 (40.2) | 0.008 |
Normal | 935 (98.7) | 382 (99.2) | 553 (98.4) | 0.267 |
Renal dysfunction/failure | 12 (1.3) | 3 (0.8) | 9 (1.6) | |
Fractional Tubular PO4 reabsorption %, mean (SD) | 92.1 (6.1) | 92.7 (5.7) | 91.7 (6.3) | 0.047 |
Normal | 734 (95.7) | 325 (95.3) | 409 (96.0) | 0.634 |
Abnormal Fractional Tubular PO4 reabsorption | 33 (4.3) | 16 (4.7) | 17 (4.0) | |
Proteinuria on dipstick (mg/dl) | ||||
Negative | 646 (69.5) | 298 (78.6) | 348 (63.2) | <0.001 |
Trace (1–30) | 120 (12.9) | 38 (10.0) | 82 (14.9) | |
Positive (30+) | 164 (17.6) | 43 (11.3) | 121 (22.0) | |
Serum urea (mmol/L), mean (SD) | 3.1 (1.3) | 3.0 (1.2) | 3.2 (1.4) | 0.001 |
Desirable | 944 (99.8) | 384 (100.0) | 560 (99.6) | 0.242 |
Abnormal (>11.9) | 2 (0.2) | 0 (0.0) | 2 (0.4) | |
Serum creatinine (µmol/L), mean (SD) | 65.5 (20.3) | 64.0 (18.5) | 66.8 (20.8) | 0.023 |
Desirable | 930 (98.2) | 381 (99.0) | 549 (97.7) | 0.147 |
Abnormal (>109) | 17 (1.8) | 4 (1.0) | 13 (2.3) | |
Serum phosphates (mmol/L), mean (SD) | 1.0 (0.3) | 1.0 (0.2) | 1.1 (0.3) | 0.023 |
Hypophosphataemia (<0.81) | 122 (13.1) | 64 (16.6) | 58 (10.6) | 0.012 |
Normal (0.81–1.5) | 799 (85.5) | 318 (82.6) | 481 (87.6) | |
Hyperphosphataemia (>1.5) | 13 (1.4) | 3 (0.8) | 10 (1.8) | |