|
Predictor
|
Level
|
Unadjusted hazard ratio (95 % CI)
|
p value
|
Adjusted hazard ratio (95 % CI)
|
p value
|
|---|
|
Sex
|
Female
|
Ref.
| |
Ref.
| |
|
Male
|
0.94 (0.90–0.98)
|
<0.01
|
0.94 (0.90–0.98)
|
<0.01
|
|
Age
|
<20
|
Ref.
| |
Ref.
| |
|
20–39
|
0.81 (0.74–0.89)
|
<0.01
|
0.87 (0.79–0.96)
|
<0.01
|
|
40–59
|
0.79 (0.71–0.87)
|
<0.01
|
0.86 (0.78–0.96)
|
<0.01
|
|
60+
|
0.86 (0.67–1.11)
|
0.26
|
1.07 (0.82–1.39)
|
0.61
|
|
WHO stage at ART initiation
|
1
|
Ref.
| |
Ref.
| |
|
2
|
1.07 (0.98–1.17)
|
0.15
|
1.03 (0.95–1.13)
|
0.47
|
|
3
|
1.12 (1.05–1.21)
|
<0.01
|
1.10 (1.02–1.18)
|
<0.01
|
|
4
|
1.23 (1.14–1.33)
|
<0.01
|
1.21 (1.12–1.30)
|
<0.01
|
|
CD4 count at ART initiation* (cells/μL)
|
<200
|
Ref.
| |
Ref.
| |
|
200–350
|
0.87 (0.82–0.93)
|
<0.01
|
0.89 (0.83–0.95)
|
<0.01
|
|
>350
|
0.86 (0.78–0.95)
|
<0.01
|
0.87 (0.78–0.96)
|
<0.01
|
|
Marital status
|
Not married
|
Ref.
| |
Ref.
| |
|
Married
|
0.97 (0.93–1.01)
|
0.18
|
1.02 (0.97–1.06)
|
0.48
|
|
Region
|
Africa
|
Ref.
| |
Ref.
| |
|
Asia
|
0.79 (0.75–0.83)
|
<0.01
|
0.82 (0.78–0.87)
|
<0.01
|
- * Individuals with missing CD4 counts were modelled as having missing data and not excluded from the analysis. Compared to the reference group (CD4 count <200) the aHR for those with missing CD4 data was 0.99 (0.94–1.03) p = 0.57
