Table 3 Unadjusted cox proportional hazard model for blip participants compared to controls
Blip group N (%) or mean (SD) | Control group N (%) or mean (SD) | Univariate hazard ratio (95 % CI) | P value | |
|---|---|---|---|---|
Number, n | 99 | 673 | ||
Demographics | ||||
Mean age at ART (years) | 34.4 (14.9) | 32.9 (13.4) | 1.00 (0.98,1.02) | 0.9756 |
Mean age at HIV diagnosis (years) | 29.8 (12.4) | 29.1 (12.8) | 1.00 (0.98,1.02) | 0.7467 |
Gender | ||||
Male | 94 (94.9) | 630 (93.6) | Ref | |
Female | 5 (5.1) | 43 (6.4) | 0.66 (0.27,1.63) | 0.3735 |
Race | ||||
Caucasian | 38 (38.4) | 267 (39.7) | Ref | |
African-American | 49 (49.5) | 278 (41.3) | 1.22 (0.80,1.86) | 0.3632 |
Other | 12 (12.1) | 128 (19.0) | 0.73 (0.38,1.39) | 0.3332 |
Time from HIV negative to seroconversion (years) | 0.7 (0.6) | 0.6 (0.6) | 1.24 (1.04,1.49) | 0.0186 |
Time from seroconversion to first ART (years) | 1.7 (2.8) | 1.7 (2.5) | 1.02 (0.95,1.11) | 0.536 |
Viral load at HIV diagnosis (log10copies/mL) | 4.6 (0.9) | 4.4 (1.0) | 1.32 (0.99,1.76) | 0.0577 |
Viral load at ART initiation (log10copies/mL) | 4.8 (0.9) | 4.5 (1.0) | 1.45 (1.11,1.89) | 0.0064 |
Viral load at ART Initiation | 69,368 (115,313) | 32,281 (86,112) | 1.00 (1.00,1.00) | 0.3596 |
CD4 cell count at HIV diagnosis (cells/mL) | 432 (308) | 439 (265) | 1.00 (1.00,1.00) | 0.2717 |
CD4 cell count at HIV diagnosis (cells/mL) | ||||
<350 | 33 (36.3) | 181 (29.9) | Ref | |
350 to <500 | 25 (27.5) | 188 (31.1) | 0.74 (0.44,1.24) | 0.2563 |
≥500 | 33 (36.3) | 236 (39.0) | 0.78 (0.48,1.27) | 0.3223 |
CD4 cell count at ART initiation (cells/mL) | 284 (190) | 353 (189) | 1.00 (1.00,1.00) | 0.0553 |
CD4 cell count at ART initiation (cells/mL) | ||||
<350 | 64 (68.1) | 305 (49.7) | Ref | |
350 to <500 | 22 (23.4) | 190 (30.9) | 0.61 (0.38,0.99) | 0.0472 |
≥500 | 8 (8.5) | 119 (19.4) | 0.39 (0.19, 0.82) | 0.0131 |
HIV medication adherence history | ||||
Self-reported antiretroviral drug adherence (%) | ||||
≥85 | 96 (98.0) | 637 (96.2) | Ref | |
<85 | 2 (2.0) | 25 (3.8) | 0.52 (0.13, 2.10) | 0.358 |
Self-reported last time missed a dose | ||||
Last week | 16 (16.3) | 98 (14.8) | Ref | |
Longer than last week | 82 (83.7) | 563 (85.2) | 0.88 (0.52,1.51) | 0.6532 |
Self-reported missed a dose in the last weekend | ||||
Yes | 3 (3.1) | 45 (6.8) | Ref | |
No | 95 (96.9) | 612 (93.2) | 0.44 (0.14,1.40) | 0.166 |
Self-reported total missed doses in the last 2 weeks | ||||
0 | 80 (81.6) | 529 (80.0) | Ref | |
1 or more | 18 (18.4) | 126 (19.1) | 0.94 (0.56,1.57) | 0.809 |
All | 0 (0.0) | 4 (0.6) | ||
Don’t know | 0 (0.0) | 2 (0.3) | ||