HIV patients stable on ART retain evidence of a high CMV load but changes to Natural Killer cell phenotypes reflect both HIV and CMV

Table 2 In HIV patients, NK expression of CD57 correlated directly with CD107a⁺ and perforin^hi expression on CD56^lo cells and inversely with IFNγ responses and the CD56^hi perforin^lo phenotype

Population assessed as % NK cells expressing….	HIV patients		CMV+ controls		CMV− Controls
Population assessed as % NK cells expressing….	P ^a	R ^a	P	R	P	R
LIR-1 (MFI on NK cells) vs….
CD107a	0.01	0.56	0.15	0.38	0.49	0.26
CD107a with K562	0.02	0.31	0.26	0.31	0.23	0.45
CD57 vs….
CD107a	0.02	0.56	0.73	0.09	0.43	−0.3
CD107a with K562	0.08	0.40	0.28	−0.30	0.70	0.15
IFNγ	0.10	−0.41	0.06	−0.48	0.61	−0.2
IFNγ with K562	0.14	−0.35	0.09	−0.44	0.17	0.5
CD56^loperforin^hi	0.001	0.72	0.28	0.29	0.49	0.27
CD56^hiperforin^lo	0.004	−0.64	0.86	0.05	0.64	0.23

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