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Table 6 Adjusted hazard ratios with confidence intervals from a Cox model after multiple imputation for all HIV-infected deaths during TB treatment according to age group (<45 years vs. ≥45 years of age)

From: Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study

 

<45 years

≥45 years

aHR (95 % CI)

p value

aHR (95 % CI)

p value

Sex female

1.10 (0.92–1.31)

0.310

1.44 (1.04–2.01)

0.030

Anatomic site of TB

 Pulmonary

Reference

 

Reference

 

 Extra-pulmonary

1.14 (0.89–1.46)

0.273

1.05 (0.66–1.66)

0.838

 Both

1.33 (1.00–1.80)

0.052

1.09 (0.59 – 2.01)

0.775

Prior TB

1.13 (0.93–1.37)

0.234

1.39 (0.98–1.97)

0.066

TB smear result

 Smear negative

Reference

 

Reference

 

 Smear positive

1.08 (0.87–1.33)

0.471

0.94 (0.63–1.39)

0.741

 No smear performed

1.16 (0.89–1.52)

0.262

0.81 (0.48–1.39)

0.447

CD4 count

 <50

Reference

 

Reference

 

 50–100

0.76 (0.57–1.02)

0.065

0.92 (0.54–1.59)

0.771

 100–200

0.51 (0.37–0.70)

<0.001

0.62 (0.38–1.04)

0.068

 200–350

0.44 (0.33–0.58)

<0.001

0.40 (0.23–0.70)

0.002

 350+

0.23 (0.15–0.37)

<0.001

0.29 (0.13–0.67)

0.005

TMP-SMX chemoprophylaxis

0.83 (0.54–1.27)

0.393

0.96 (0.30–3.04)

0.936

ART during TB treatment

0.67 (0.44–0.83)

<0.001

0.44 (0.27–0.72)

0.001

  1. TB tuberculosis, ART antiretroviral treatment, TMP-SMX trimethoprim sulfamethoxazole 160/80 mg chemoprophylaxis, aHR adjusted hazard ratio, 95 % CI 95 % confidence interval
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AIDS Research and Therapy

ISSN: 1742-6405

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