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Table 2 Crude and adjusted hazard ratios with confidence intervals from a Cox model after multiple imputation for all deaths during TB treatment

From: Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study

 

Crude

Adjusted

Adjusted (selected by AIC*)

HR (95 % CI)

p value

HR (95 % CI)

p value

HR (95 % CI)

Sex female

1.05 (0.91–1.20)

0.51

1.08 (0.94–1.24)

0.28

 

Age

 <25

Reference

 

Reference

 

Reference

 25–35

1.88 (1.42–2.48)

0.00

1.53 (1.15–2.03)

0.00

1.52 (1.14–2.01)

 35–45

2.37 (1.78–3.14)

0.00

1.93 (1.45–2.58)

0.00

1.90 (1.43–2.53)

 45–60

3.54 (2.66–4.72)

0.00

3.25 (2.42–4.35)

0.00

3.20 (2.40–4.27)

 >60

6.54 (4.65–9.19)

0.00

7.22 (5.11–10.22)

0.00

7.22 (5.11–10.19)

Anatomic site of TB

 Pulmonary

Reference

 

Reference

 

Reference

 Extra-pulmonary

1.38 (1.18–1.62)

0.00

1.20 (0.99–1.45)

0.06

1.29 (1.10–1.51)

 Both

1.62 (1.27–2.06)

0.00

1.45 (1.14–1.85)

0.00

1.46 (1.15–1.86)

Prior TB

1.28 (1.11–1.49)

0.00

1.16 (1.00–1.35)

0.05

1.16 (1.00–1.34)

HIV infected

1.82 (1.51–2.20)

0.00

1.94 (1.58–2.40)

0.00

2.00 (1.63–2.46)

TB smear result

 Smear negative

Reference

 

Reference

  

 Smear positive

0.73 (0.63–0.84)

0.00

0.93 (0.79–1.10)

0.41

 

 No smear performed

1.11 (0.91–1.36)

0.31

1.08 (0.87–1.34)

0.47

 
  1. TB tuberculosis, ART antiretroviral treatment, TMP-SMX trimethoprim sulfamethoxazole 160/80 mg chemoprophylaxis, HR  hazard ratio, 95 % CI 95 % confidence interval, AIC Akaike information criterion