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Table 4 Association between minor protease inhibitor resistance mutations, viral load and CD4+ T cell count

From: HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and -experienced injection drug users and non-drug users

  Injection drug users
ART (−) ART (+)
Mutation (−), n = 18 Mutation (+), n = 13 P Mutation (−), n = 30 Mutation (+), n = 14 P
CD4+ T cell count/μl 529 (276) 568 (597) 0.708 412 (415) 424 (648) 0.762
Log10 HIV-1 RNA, copies/ml 4.4 (2.7) 2.2 (1.9) 0.183 3.6 (2.7) 2.2 (1.7) 0.142
  Non-drug users
ART (−) ART (+)
Mutation (–), n = 7 Mutation (+), n = 14 P Mutation (−), n = 17 Mutation (+), n = 15 P
CD4+ T cell count/μl 989 (507) 455 (599) 0.005 351 (526) 554 (461) 0.350
Log10 HIV-1 RNA, copies/ml 3.6 (1.9) 4.8 (2.5) 0.313 4.3 (1.3) 4.3 (2.0) 0.852
  1. Data presented are medians (IQR, interquartile range) in carriers and non-carriers of only minor protease resistance mutations. Statistical analysis was performed using Mann–Whitney test
  2. Significant P-values are shown in italic
  3. ART (−) anti-retroviral treatment-naive, ART (+) anti-retroviral treatment-experienced, Mutation (+) minor protease resistance mutation carrier, Mutation (−) minor protease resistance mutation non-carrier, HIV-1 human immunodeficiency virus type