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Table 4 Association between minor protease inhibitor resistance mutations, viral load and CD4+ T cell count

From: HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and -experienced injection drug users and non-drug users

 

Injection drug users

ART (−)

ART (+)

Mutation (−), n = 18

Mutation (+), n = 13

P

Mutation (−), n = 30

Mutation (+), n = 14

P

CD4+ T cell count/μl

529 (276)

568 (597)

0.708

412 (415)

424 (648)

0.762

Log10 HIV-1 RNA, copies/ml

4.4 (2.7)

2.2 (1.9)

0.183

3.6 (2.7)

2.2 (1.7)

0.142

 

Non-drug users

ART (−)

ART (+)

Mutation (–), n = 7

Mutation (+), n = 14

P

Mutation (−), n = 17

Mutation (+), n = 15

P

CD4+ T cell count/μl

989 (507)

455 (599)

0.005

351 (526)

554 (461)

0.350

Log10 HIV-1 RNA, copies/ml

3.6 (1.9)

4.8 (2.5)

0.313

4.3 (1.3)

4.3 (2.0)

0.852

  1. Data presented are medians (IQR, interquartile range) in carriers and non-carriers of only minor protease resistance mutations. Statistical analysis was performed using Mann–Whitney test
  2. Significant P-values are shown in italic
  3. ART (−) anti-retroviral treatment-naive, ART (+) anti-retroviral treatment-experienced, Mutation (+) minor protease resistance mutation carrier, Mutation (−) minor protease resistance mutation non-carrier, HIV-1 human immunodeficiency virus type