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Table 3 HIV-1 viral load and CD4+ T cell counts of individuals with major protease inhibitor drug resistance mutations

From: HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and -experienced injection drug users and non-drug users

ID

Mutation

Age, years

Gender

ART duration, years

HIV-1 RNA (log10 HIV-1 RNA), copies/ml

CD4+ T cells/ml

#1

D30N + M46I + G48E

36.4

M

<0.5

4624 (3.7)

473

#2

L90M + K20R

34.6

M

1–3

291,124 (5.5)

637

#3

D30N + M46I + K20I

30.1

F

1–3

141,341 (5.2)

39

#4

D30N + T74S + K20R

33.3

M

Naive

209,871 (5.3)

162

  1. Mutations are denoted according to Stanford drug resistance database and International Antiviral Society-USA drug resistance mutations panel [12, 39, 40]
  2. Major mutations are shown in bold
  3. D aspartic acid, E glutamic acid, G glycine, I isoleucine, K lysine, L leucine, M methionine, N asparagine, S serine; T threonine, ART antiretroviral therapy, HIV-1 human immunodeficiency virus type-1
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AIDS Research and Therapy

ISSN: 1742-6405

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